Sodium/hydrogen exchanger 3

BE0009757ProteinHumansSLC9A3

Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). It is acted on by 7 drugs in DrugBank.

Gene name
SLC9A3
UniProtKB entry
P48764Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
834 residues · 92,854 Da
Also known as
Na(+)/H(+) exchanger 3 · NHE-3 · NHE3 · Solute carrier family 9 member 3

Resolves to

Protein
UniProtP48764UniProt nameSL9A3_HUMAN
Gene
HGNCHGNC:11073NCBI Gene6550GeneCardsSLC9A3
Pharmacology
IUPHAR/GtoPdb950KEGGhsa:6550
Structure
PDB7X2U
Drugs

What you can answer from here — as of September 13, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/hydrogen exchanger 3, how selective are they, and which programs against it are still in active trials?

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