Identification

Summary

Sodium chloride is an ingredient found in a variety of nutritional products as a source of electrolytes and water.

Brand Names
Amphenol-40, As 3, Bi-peglyte, Bicart, Bss, Bss Ophthalmic Solution, Cardioplegic, Citrasate, Clinimix E 2.75/5, Colyte, Corvatrol, Dextrose and Electrolyte No. 75, Dianeal, Dianeal Low Calcium 1.5, Dianeal Pd-2/1.5, Entocort, Extraneal, Eye Stream, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hemosate Ultra, Hespan, Hizentra, Hyperlyte, Intersol, Isolyte S, Isolyte S pH 7.4, Isoplate, Lactate 1-2-3, Lactated Ringers, Menopur, Moviprep, Muro 128, Naturalyte, Normosol-M, Normosol-R, Nulytely, Nxstage Pureflow, P-Care M, P-Care MG, P-care, P-care X, Peglyte, Phoxillum, Physiolyte, Physioneal 40, Physiosol, Plasma-lyte, Plasma-lyte 148, Plasma-lyte 148 In 5 % Dextrose, Plasma-lyte R, Plasmalyte A, Plegisol, Plenvu, Prismasol, Procalamine 3, Ringers, Sag-M, Sclerodex, Tis-U-sol
Generic Name
Sodium chloride
DrugBank Accession Number
DB09153
Background

Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the primary salt in seawater and in the extracellular fluid of many multicellular organisms. It is listed on the World Health Organization Model List of Essential Medicines.

Type
Small Molecule
Groups
Approved, Vet approved
Structure
Weight
Average: 58.443
Monoisotopic: 57.958622382
Chemical Formula
ClNa
Synonyms
  • Cloruro sódico
  • Natriumchlorid
  • Natrum muriaticum
  • Sodium chloride
External IDs
  • B1655
  • LS-1700
  • NSC-77364

Pharmacology

Indication

This intravenous solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration. Also, designed for use as a diluent and delivery system for intermittent intravenous administration of compatible drug additives.

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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance, and osmotic pressure of body fluids. Sodium is also associated with chloride and bicarbonate in the regulation of the acid-base equilibrium of body fluid. Chloride, the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in the chloride concentration.

Mechanism of action

Sodium and chloride — major electrolytes of the fluid compartment outside of cells (i.e., extracellular) — work together to control extracellular volume and blood pressure. Disturbances in sodium concentrations in the extracellular fluid are associated with disorders of water balance.

Absorption

Absorption of sodium in the small intestine plays an important role in the absorption of chloride, amino acids, glucose, and water. Chloride, in the form of hydrochloric acid (HCl), is also an important component of gastric juice, which aids the digestion and absorption of many nutrients.

Volume of distribution

The volume of distribution is 0.64 L/kg.

Protein binding

Sodium is not bound by plasma proteins.

Metabolism

The salt that is taken in to gastro intestinal tract remains for the most part unabsorbed as the liquid contents pass through the stomach and small bowel. On reaching the colon this salt, together with the water is taken in to the blood. As excesses are absorbed the kidney is constantly excreting sodium chloride, so that the chloride level in the blood and tissues remains fairly constant.Further more, if the chloride intake ceases, the kidney ceases to excrete chlorides. Body maintains an equilibrium retaining the 300gm of salt dissolved in the blood and fluid elements of the tissue dissociated into sodium ions and chloride ions.

Route of elimination

Substantially excreted by the kidneys.

Half-life

17 minutes

Clearance

Not Available

Adverse Effects
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Toxicity

The rare inadvertent intravascular administration or rapid intravascular absorption of hypertonic sodium chloride can cause a shift of tissue fluids into the vascular bed, resulting in hypervolemia, electrolyte disturbances, circulatory failure, pulmonary embolism, or augmented hypertension.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Lithium carbonateSodium chloride may increase the excretion rate of Lithium carbonate which could result in a lower serum level and potentially a reduction in efficacy.
Lithium citrateSodium chloride may increase the excretion rate of Lithium citrate which could result in a lower serum level and potentially a reduction in efficacy.
Lithium hydroxideSodium chloride may increase the excretion rate of Lithium hydroxide which could result in a lower serum level and potentially a reduction in efficacy.
TolvaptanThe risk or severity of adverse effects can be increased when Sodium chloride is combined with Tolvaptan.
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Food Interactions
No interactions found.

Products

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Active Moieties
NameKindUNIICASInChI Key
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Chloride ionionicQ32ZN4869816887-00-6VEXZGXHMUGYJMC-UHFFFAOYSA-M
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
0.45% Sodium Chloride Injection USPSolution4.5 mg / mLIntravenousB. Braun Medical Inc.1993-12-31Not applicableCanada flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2018-10-16Not applicableUS flag
0.9% Sodium ChlorideInjection, solution9 mg/1mLIntramuscular; Intravenous; SubcutaneousHF Acquisition Co LLC, DBA HealthFirst2019-07-18Not applicableUS flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2020-04-07Not applicableUS flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2020-05-21Not applicableUS flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2020-04-07Not applicableUS flag
0.9% Sodium ChlorideIrrigant900 mg/100mLIrrigationHF Acquisition Co LLC, DBA HealthFirst2018-10-18Not applicableUS flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousSc Infomed Fluids Srl2017-04-242017-04-24US flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2018-10-18Not applicableUS flag
0.9% Sodium Chloride InjectionSolution900 mg / 100 mLIntravenousFresenius Kabi2013-12-10Not applicableCanada flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
0.9% Sodium ChlorideInjection, solution9 mg/1mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2021-07-17Not applicableUS flag
3% Sodium ChlorideInjection, solution3 g/100mLIntravenousBecton Dickinson and Company2020-02-28Not applicableUS flag
Amphenol-40Injection, solution9 mg/1mLIntramuscular; Intravenous; SubcutaneousIt3 Medical Llc2017-03-01Not applicableUS flag
Bacteriostatic Sodium ChlorideInjection9 mg/1mLIntramuscular; Intravenous; SubcutaneousFresenius Kabi USA, LLC2000-08-08Not applicableUS flag
Bacteriostatic Sodium ChlorideInjection9 mg/1mLIntramuscular; Intravenous; SubcutaneousCardinal Health2000-08-082016-03-31US flag
Corvatrol 0.9%Injection9 mg/1mLIntramuscular; Intravenous; SubcutaneousIt3 Medical Llc2017-03-01Not applicableUS flag
HAEMONETICS 0.9 % Sodium ChlorideSolution900 mg/100mLExtracorporealHaemonetics Corporation2013-01-07Not applicableUS flag
Sodium ChlorideInjection9 mg/1mLIntravenousCardinal Health2000-08-102013-12-31US flag
Sodium chlorideInjection, solution9 mg/1mLIntravenousFresenius Kabi USA, LLC2017-09-19Not applicableUS flag
Sodium chlorideInjection, solution450 mg/100mLIntravenousFresenius Kabi USA, LLC2018-07-23Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
0.9% SODIUM CHLORIDE (500ML ROUND PLASTIC CONTAINER)Solution0.9 %POLYLAB BIOTECH SDN. BHD.2016-03-032019-05-10Malaysia flag
0.9% SODIUM CHLORIDE PARENTERAL SOLUTION (1000ML PLASTIC)Solution0.9 %ParenteralPOLYLAB BIOTECH SDN. BHD.2017-07-042019-05-10Malaysia flag
Altachlore Sodium Chloride HypertonicitySolution / drops50 mg/1mLOphthalmicAltaire Pharmaceuticals Inc.2002-09-24Not applicableUS flag
Ancient Secrets Breathe AgainAerosol, spray20 mg/100mLNasalLotus Brands, Inc.2011-08-15Not applicableUS flag
Ancient Secrets Breathe Again ChildrensAerosol, spray20 mg/100mLNasalLotus Brands, Inc.2011-08-152015-06-01US flag
Aqua Maris BabyLiquid11.25 mg/1mLNasalJgl North America Llc2010-07-08Not applicableUS flag
Aqua Maris BabyLiquid9 mg/1mLNasalJGL d. d.2022-05-04Not applicableUS flag
Aqua Maris ClassicSpray10.5 mg/1mLNasalJGL d. d.2022-05-06Not applicableUS flag
Aqua Maris CleanSpray9 mg/1mLNasalJGL d. d.2022-05-05Not applicableUS flag
Aqua Maris CleanSpray9 mg/1mLNasalJGL d. d.2022-05-05Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
(20 Mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USPSodium chloride (300 mg / 100 mL) + Dextrose, unspecified form (3.3 g / 100 mL) + Potassium chloride (150 mg / 100 mL)SolutionIntravenousBaxter Laboratories1978-12-31Not applicableCanada flag
(20 Mmol/l) Potassium Chloride In 5% Dextrose and 0.9% Sodium Chloride Injection USPSodium chloride (900 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Potassium chloride (150 mg / 100 mL)SolutionIntravenousBaxter Laboratories1990-12-31Not applicableCanada flag
(20mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USPSodium chloride (900 mg / 100 mL) + Potassium chloride (150 mg / 100 mL)SolutionIntravenousBaxter Laboratories1989-12-31Not applicableCanada flag
(20mmol/l) Potassium Chloride In 5% Dextrose and 0.2% Sodium Chloride Injection USPSodium chloride (200 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Potassium chloride (150 mg / 100 mL)SolutionIntravenousBaxter Laboratories1989-12-312016-07-15Canada flag
(20mmol/l) Potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USPSodium chloride (450 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Potassium chloride (150 mg / 100 mL)SolutionIntravenousBaxter Laboratories1989-12-31Not applicableCanada flag
(40 Mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USPSodium chloride (900 mg / 100 mL) + Potassium chloride (300 mg / 100 mL)LiquidIntravenousBaxter Laboratories1989-12-31Not applicableCanada flag
(40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USPSodium chloride (600 mg / 100 mL) + Calcium chloride (20 mg / 100 mL) + Sodium lactate (310 mg / 100 mL) + Potassium chloride (328 mg / 100 mL)SolutionIntravenousBaxter Laboratories2002-12-112016-07-15Canada flag
(40mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USPSodium chloride (300 mg / 100 mL) + Dextrose, unspecified form (3.3 g / 100 mL) + Potassium chloride (300 mg / 100 mL)SolutionIntravenousBaxter Laboratories1978-12-31Not applicableCanada flag
(40mmol/l)potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USPSodium chloride (450 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Potassium chloride (300 mg / 100 mL)SolutionIntravenousBaxter Laboratories1989-12-31Not applicableCanada flag
%5 DEKSTROZ %0,2 SODYUM KLORUR COZELTISI SETLI, 100 MLSodium chloride (5 %) + D-glucose monohydrate (0.2 %)SolutionIntravenousKOÇAK FARMA İLAÇ VE KİMYA SAN. A.Ş.2020-08-14Not applicableTurkey flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
%0,9 IZOTONIK 1000 ML SOLUSYON(SETLI)Sodium chloride (0.9 %)SolutionIntravenousPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
%0,9 IZOTONIK 500 ML SOLUSYON(SETLI)Sodium chloride (0.9 %)SolutionIntravenousPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
%0,9 IZOTONIK 500 ML SOLUSYON(SETSIZ)Sodium chloride (0.9 %)SolutionIntravenousPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
%0,9 IZOTONIK SODYUM KLORUR 250 ML SOLUSYON(SETLI)Sodium chloride (0.9 %)SolutionIntravenousPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
%0,9 IZOTONIK SODYUM KLORUR 250 ML SOLUSYON(SETSIZ)Sodium chloride (0.9 %)SolutionIntravenousPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
%0,9 IZOTONIK SODYUM KLORUR ICEREN IRRIGASYON SOLUSYONU 1000 ML (POLIPROPILEN SISE)Sodium chloride (0.9 %)SolutionOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
%0,9 IZOTONIK SODYUM KLORUR ICEREN IRRIGASYON SOLUSYONU 500 ML (POLIPROPILEN SISE)Sodium chloride (0.9 %)SolutionOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
%0,9 SODYUM KLORUR 10 ML 10 AMPULSodium chloride (0.9 %)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
%0,9 SODYUM KLORUR 250 ML SOLUSYON SETSIZSodium chloride (0.9 %)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
%09 IZOTONIK 1000 ML SOLUSYONSodium chloride (9 %)SolutionIntravenousPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag

Categories

ATC Codes
B05XA03 — Sodium chlorideB05CB01 — Sodium chlorideA12CA01 — Sodium chloride
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkali metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal salts
Sub Class
Alkali metal chlorides
Direct Parent
Alkali metal chlorides
Alternative Parents
Inorganic sodium salts / Inorganic chloride salts
Substituents
Alkali metal chloride / Inorganic chloride salt / Inorganic salt / Inorganic sodium salt
Molecular Framework
Not Available
External Descriptors
inorganic chloride, inorganic sodium salt (CHEBI:26710)
Affected organisms
Not Available

Chemical Identifiers

UNII
451W47IQ8X
CAS number
7647-14-5
InChI Key
FAPWRFPIFSIZLT-UHFFFAOYSA-M
InChI
InChI=1S/ClH.Na/h1H;/q;+1/p-1
IUPAC Name
sodium chloride
SMILES
[Na+].[Cl-]

References

General References
  1. ChemIDplus [Link]
  2. Pubchem [Link]
KEGG Drug
D02056
KEGG Compound
C13563
PubChem Compound
5234
PubChem Substance
310265066
ChemSpider
5044
BindingDB
50098543
RxNav
9863
ChEBI
26710
ChEMBL
CHEMBL1200574
PharmGKB
PA451382
Wikipedia
Sodium_chloride
MSDS
Download (89.8 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingTreatmentAllergic Rhinitis (AR) / Allergy to Tree Pollen / Seasonal Allergic Rhinitis1
4Active Not RecruitingTreatmentBlood Loss During Surgery1
4Active Not RecruitingTreatmentBurns / Surgery / Tranexamic Acid / Wounds and Injuries1
4Active Not RecruitingTreatmentCaudal epidural block therapy / Postoperative pain1
4Active Not RecruitingTreatmentChildren, Only / Pain / Remifentanil / Tonsillectomy1
4Active Not RecruitingTreatmentEndothelial Dysfunction / Iron Toxicity / Renal Anemia / Stress Oxidative1
4Active Not RecruitingTreatmentHeadache1
4CompletedNot AvailableBrain Swelling1
4CompletedNot AvailableColonoscopy1
4CompletedNot AvailableCorneal Staining1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntravenous0.9 %
SolutionIntravenous20 %
SolutionIntravenous3 %
SolutionIntravenous4.5 mg / mL
SolutionIntramuscular; Intravenous; Subcutaneous9 mg / mL
SolutionIntravenous900 mg / 100 mL
SolutionIrrigation0.9 %
SolutionIrrigation900 mg / 100 mL
SolutionIrrigation1.6 g / 100 mL
InjectionIntravenous50 g/L
SolutionIrrigation12 g / 100 mL
SolutionIntravenous20 % w/v
SolutionIntravenous23.4 %
LiquidIntravenous30 mg / mL
KitIrrigation; Ophthalmic; Respiratory (inhalation); Topical
KitIrrigation; Ophthalmic; Topical
KitIrrigation; Oral; Respiratory (inhalation); Topical
KitIrrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical
SolutionIntravenous5 g / 100 mL
SolutionHemodialysis0.257 g/1000ml
SolutionRespiratory (inhalation)0.45 %
SolutionRespiratory (inhalation)0.9 %
SolutionRespiratory (inhalation)450 mg / 100 mL
SolutionRespiratory (inhalation)900 mg / 100 mL
SolutionParenteral9 mg
KitIntradermal; Subcutaneous
SolutionTopical9 mg/ml
Solution; sprayNasal9 mg/ml
SolutionIrrigation; Parenteral
Powder, for solutionIntraocular
SolutionIntraocular
Aerosol, sprayNasal20 mg/100mL
LiquidTopical
LiquidNasal11.25 mg/1mL
LiquidNasal9 mg/1mL
SprayNasal10.5 mg/1mL
SprayNasal9 mg/1mL
SprayAuricular (otic)11.25 mg/1mL
SprayOral37.5 mg/1mL
SprayNasal0.9 mg/100mL
SprayNasal0.9 g/100mL
InhalantRespiratory (inhalation)1.7 mg/1mL
SolutionIntravenous drip
LiquidRespiratory (inhalation)0.9 %
SolutionOphthalmic
LiquidDental0.5 g/100mL
Solution / dropsNasal
Solution; sprayNasal
Kit; powder, for solution; tablet, delayed releaseOral
Kit; powder, for solutionHemodialysis
Powder, for solutionOral1.685 g
Liquid; powder, for solutionSubcutaneous
SolutionHemodialysis; Intravenous
SolutionHemodialysis; Intravenous0.187 g/L
LiquidOral0.5 g/100mL
Solution / drops; suspension / drops
SprayNasal
Aerosol, meteredRespiratory (inhalation).9 %
Kit; solutionIntraocular
LiquidOphthalmic
LiquidTopical0.495 g/50mL
LiquidTopical0.99 g/100mL
LiquidTopical2.97 g/300mL
LiquidTopical4.95 g/500mL
PowderTopical60 g/300g
SolutionIntraperitoneal0.2573 g/l
SolutionIntraperitoneal0.1838 g/L
Solution
SolutionIntra-arterial
EnemaRectal15 %
SolutionNasal.9 %
SolutionNasal; Ophthalmic900 mg/100mL
SwabTopical0.9 g/100mL
LiquidNasal6.5 mg/1mL
SolutionIntramuscular; Intravenous; Subcutaneous9 mg
SolutionIntravenous9 g
SolutionIntravenous; Irrigation9 mg
Solution, concentrateIntravenous11.7 g
SolutionIntravenous1.17 g
SolutionIntravenous20 mEq
SolutionParenteral20 MBq
SolutionIntravenous0.009 g
SolutionIntravenous900 mg
InjectionIntravenous10 g
SolutionIntravenous1.1688 g
SolutionIntravenous116.9 mg
Powder, for solutionNasogastric
SolutionIntravenous0.27 g/1000ml
InjectionIntravenous0.027 g/100ml
InjectionIntravenous270 mg/l
Injection, powder, lyophilized, for solutionHemodialysis
LiquidOphthalmic0.9 g/100mL
LiquidEpidural; Infiltration; Subcutaneous
OintmentTopical5 %
SolutionTopical5 %
SolutionOphthalmic
PowderNasal
SprayNasal0.9 g/100g
SolutionIrrigation
Paste, dentifriceOral
SolutionIntraperitoneal
InjectionIntravenous5.0 % w/v
LiquidIntravenous
InjectionIntravenous5 g/100ml
InjectionIntravenous
SolutionRespiratory (inhalation).45 %
SolutionRespiratory (inhalation)10 %
SolutionRespiratory (inhalation)3 %
LiquidTopical.9 %
SolutionIntraperitoneal; Irrigation
SolutionIntraperitoneal18.3 mg/100ml
Injection, solutionIntraperitoneal
InjectionSubcutaneous4.5 mg/0.5mL
LiquidIntradermal; Percutaneous; Subcutaneous
LiquidSubcutaneous
SolutionIntravenous1.47 mg/1ml
KitEpidural; Infiltration; Intracaudal; Subcutaneous; Topical
Injection, solution, concentrateIntramuscular
SolutionOphthalmic0.02 %
SprayTopical
SprayNasal0.39 mL/60mL
SolutionIntravenous4.21 g/1000ml
KitIntra-articular; Intralesional; Intramuscular; Soft tissue; Topical
LiquidOphthalmic0.48 %
Granule, for solutionOral
Injection, solutionIntravenous1000 ML
SolutionIntrathecal
InjectionIntrathecal
SolutionIntravenous; Subcutaneous
PowderOral
SolutionRectal2.5 g
Enema; kit; tabletRectal
SprayNasal30 mg/1mL
KitEpidural; Infiltration
SolutionIntraperitoneal25.7 mg/100ml
SolutionIntraperitoneal257 mg/l
SolutionNasal0.29 mg/44mL
Kit; liquid; powder, for solutionIntramuscular; Subcutaneous
Liquid; powder, for solutionIntramuscular; Subcutaneous
SolutionIrrigation; Topical0.9 g
LiquidTopical1.5 g/100mL
Granule, for solutionOral64 g
SolutionIntra-articular; Irrigation0.009 g
SolutionParenteral0.9 g
SolutionIntrasinal; Nasal0.9 mg
Solution, concentrateHemodialysis
SolutionIntravenous0.15 g/1000ml
InjectionIntravenous7.01 g/1000ml
SprayOral
Aerosol, sprayOral
InjectionParenteral
Injection, solutionParenteral
Powder, for solutionNasogastric; Oral
SolutionExtracorporeal9 g
SolutionHemodialysis
SolutionHemodialysis7.77 g/l
SolutionHemodialysis6.47 g/l
SolutionHemodialysis8.46 g/l
SolutionExtracorporeal900 mg/100mL
SolutionExtracorporeal
SolutionHemodialysis8.8 g/l
SolutionHemodialysis66 g/l
SolutionHemodialysis8.85 g/l
SolutionHemodialysis9.74 g/l
LiquidHemodialysis
SolutionHemodialysis6.77 g/l
InjectionIntravenous10 iu/ml
SolutionOral0.2892 g
SolutionOphthalmic50 mg
SolutionConjunctival; Ophthalmic
SolutionNasal
EnemaRectal6 g/20ml
Liquid; powder, for solutionIntramuscular
SolutionRespiratory (inhalation)
SprayNasal
LiquidNasal.65 g/100mL
SolutionIntravenous0.9 % w/v
Injection, solutionIntravenous20 %
InjectionIntravenous
LiquidIntraperitoneal
SolutionHemodialysis; Intraperitoneal
LiquidIntravesical
LiquidIntraocular
SolutionIntravenous
Solution
SolutionIntravenous
KitIntravenous; Topical
IrrigantIrrigation
SolutionIntravenous1000 ml
SolutionIntravenous150 ml
SolutionIntravenous250 ml
SolutionIntravenous50 ml
SolutionIntravenous500 ml
SolutionIntravenous100 ml
LiquidInfiltration; Subcutaneous; Topical
SolutionRectal150 mg/ml
TabletVaginal
InjectionIntravenous20 mg/100ml
Solution, for slushIrrigation
GelVaginal
InjectionIntravenous0.027 % w/v
Solution / dropsOphthalmic
SolutionConjunctival; Ophthalmic0.09 g
Injection, solution
LiquidOral
Powder, for solutionSubcutaneous
InjectionSubcutaneous
LiquidBuccal
SprayBuccal
Powder, for solutionOral13.125 g
Powder, for solutionOral13.125 G
Injection, solution, concentrateOral
KitOral
Injection, solutionHemodialysis; Intravenous
SolutionHemodialysis1.1 g/L
SolutionOphthalmic20 mg/1mL
SolutionOphthalmic50 mg/1mL
LiquidIntraocular; Ophthalmic2 %
SolutionIntravenous117 mg
LotionTopical.65 mL/100mL
SolutionNasal; Respiratory (inhalation)9 mg
SprayNasal9.5 mg/1mL
SprayNasal2600 mg/100mL
SolutionIntrasinal; Nasal900 mg
SolutionNasal; Respiratory (inhalation)6.5 mg
SolutionNasal; Respiratory (inhalation)9.054 mg
SolutionIntrasinal; Nasal6.5 mg
SprayNasal3 mL/100mL
SprayNasal1.2 mg/10mL
SolutionIntravenous9 g/L
SolutionIntravenous1.169 g
Injection, solutionParenteral9 mg/ml
Kit; solutionIntraocular; Irrigation
SolutionIntrasinal; Nasal0.65 g
SolutionTopical9 mg
TabletOral1 g/1
EmulsionParenteral
EmulsionIntravenous
Injection, emulsionIntravenous4.656 g/1000ml
Injection, emulsionIntravenous6.792 g/1000ml
Injection, solution, concentrateIntravenous
SolutionIntraperitoneal0.184 g/l
Injection, emulsionIntravenous
OintmentOphthalmic50 mg/g
Solution, concentrateOral
SolutionIntraocular; Ophthalmic
SolutionIntraocular; Irrigation
Liquid; mouthwashOral
SolutionExtracorporeal; Intrabiliary; Intracardiac
SolutionAuricular (otic)
SolutionOral
PowderOral238.33 g
LiquidIntradermal; Subcutaneous
Injection, solution
SolutionConjunctival; Ophthalmic90000 mg
Solution0.9 %
SolutionIntraperitoneal0.507 g/l
IrrigantIrrigation
Injection, solutionIntravenous
InjectionIntravenous30 mg/100ml
Injection, solutionIntra-arterial
Powder, for solutionOral
SolutionIntravenous50 g/1000ml
SolutionIntravenous1.5 g/1000ml
SolutionIntravenous3.00 g/1000ml
SolutionHemodialysis; Intravenous0.27 g/l
KitHemodialysis
SolutionHemodialysis0.257 g/l
EnemaRectal
EnemaRectal25 % w/v
InjectionIntravenous0.21 g/100ml
DoucheVaginal
Powder, for solutionIntravenous
PatchTransdermal0.03 g/1g
Kit; liquid; powderIntralesional; Subcutaneous
Injection, solutionExtracorporeal
SolutionIntravenous5.03 g/l
Liquid; powder, for solutionIntravenous; Subcutaneous
SolutionIntravenous0.1 g/500ml
SolutionIrrigation; Topical
InjectionIntravenous0.33 g/1L
Injection, solutionIrrigation
SolutionOphthalmic0.9 % w/v
SolutionUnknown
Powder, for solutionIntramuscular; Subcutaneous
SolutionOphthalmic50.00 mg/ml
SprayNasal6.5 mg/1mL
SprayOral6.5 mg/1mL
SprayNasal2.65 mg/100mL
LiquidNasal.9 %
GelNasal0.9 g/100mL
ClothTopical0.9 g/100mL
GelNasal
AerosolOral
InjectionIntravenous0.9 % w/v
LiquidTopical5 g/100mL
LiquidTopical0.7 %
PowderTopical
Injection, solutionIntravenous0.9 %
InjectionIntravenous0.9 %
LiquidEpidural
Powder, for solutionNasal
GelNasal0.9 mg/100mL
Injection, solutionIntravenous
Injection, solutionParenteral
SolutionIrrigation
SolutionIntravenous2.25 g
SolutionIrrigation; Parenteral0.9 g
SolutionIrrigation0.9 g
SolutionIntravenous0.1169 g
SolutionIntravenous0.9 g
Injection, solutionIntravenous3 %
Injection, solutionIntravenous5 %
Injection, solutionParenteral0.9 %
Injection, solution, concentrateIntravenous2 MEQ/ML
SolutionParenteral0.9 %
SolutionParenteral9 %
Injection, solutionParenteral20 MEQ/10ML
Injection, solutionParenteral20 MEQ
Injection, solutionIntravenous18 MG/2ML
Injection, solutionIntravenous180 MG/20ML
Injection, solutionIntravenous45 MG/5ML
Injection, solutionIntravenous90 MG/10ML
Injection, solutionIrrigation0.9 %
Solution, concentrateParenteral0.117 g/ml
Injection, solution, concentrateIntravenous
Injection, solutionParenteral5 %
Injection, solution, concentrateIntravenous0.175 g
Injection, solution, concentrateIntravenous1.17 g
Injection, solution, concentrateIntravenous1.75 g
SolutionIrrigation; Parenteral0.9 %
Injection, solutionIntravenous0.45 %
Injection, solutionParenteral0.45 %
Injection, solutionParenteral3 %
Injection, solution, concentrateIntravenous3 %
Injection, solution, concentrateIntravenous3 mEq/ml
Injection, solution, concentrateIntravenous5 %
SolutionIntravenous5 %
Solution, concentrateIntravenous0.117 g/ml
Solution, concentrateIntravenous0.175 g/ml
SolutionParenteral
Solution, concentrateParenteral0.175 g/ml
SolutionIntravenous3 g
PowderHemodialysis
InhalantRespiratory (inhalation)0.9 mg/100mL
Injection
InjectionIntramuscular; Intravenous; Subcutaneous0.9 mg/10mL
InjectionIntramuscular; Intravenous; Subcutaneous234 mg/1mL
InjectionIntramuscular; Intravenous; Subcutaneous9 mg/1mL
InjectionIntravascular.9 mg/1mL
InjectionIntravenous0.45 g/50mL
InjectionIntravenous0.9 g/100mL
InjectionIntravenous450 mg/50mL
InjectionIntravenous450 mg/100mL
InjectionIntravenous9 mg/1mL
InjectionIntravenous900 mg/100mL
InjectionIntravenous900 mg/1000mL
Injection, solutionIntramuscular; Intravenous; Subcutaneous9 mg/1mL
Injection, solutionIntravenous0.45 g/100mL
Injection, solutionIntravenous0.9 g/100mL
Injection, solutionIntravenous1125 mg/250mL
Injection, solutionIntravenous146 mg/1mL
Injection, solutionIntravenous225 mg/50mL
Injection, solutionIntravenous2250 mg/500mL
Injection, solutionIntravenous234 mg/1mL
Injection, solutionIntravenous3 g/100mL
Injection, solutionIntravenous4.5 g/1000mL
Injection, solutionIntravenous450 mg/100mL
Injection, solutionIntravenous450 mg/50mL
Injection, solutionIntravenous5 g/100mL
Injection, solutionIntravenous9 mg/1mL
Injection, solutionIntravenous9 g/1
Injection, solutionIntravenous9 g/1000mL
Injection, solutionIntravenous900 mg/100mL
Injection, solution, concentrateIntravenous2.5 meq/1mL
Injection, solution, concentrateIntravenous2.92 g/20mL
Injection, solution, concentrateIntravenous234 mg/1mL
Injection, solution, concentrateIntravenous4 meq/1mL
Injection, solution, concentrateIntravenous5.84 g/40mL
IrrigantIrrigation0.9 g/100mL
IrrigantIrrigation450 mg/100mL
IrrigantIrrigation9 g/1000mL
IrrigantIrrigation900 mg/100mL
OintmentOphthalmic50 mg/1g
SolutionIntravenous0.45 g/100mL
SolutionIntravenous0.9 g/100mL
SolutionRespiratory (inhalation)0.027 mg/3mL
Solution / dropsOphthalmic50 mg/1mL
Solution, concentrateOral936 mg/4mL
InjectionIntravenous2.75 g/100ml
LiquidIntravenous450 mg / 100 mL
InjectionIntravenous5.5 g/100ml
SolutionOphthalmic0.9 g/100mL
LiquidIntravenous; Subcutaneous9 mg / mL
SolutionIntravenous3 g / 100 mL
LiquidIntravenous23.4 g / 100 mL
LiquidIntramuscular; Intravenous; Subcutaneous9 mg / mL
InjectionIntravenous20 g/100ml
SolutionIrrigation0.9 g/100mL
InhalantRespiratory (inhalation)9 g/1L
LiquidIntravenous9 mg / mL
LiquidIntramuscular; Intravenous; Subcutaneous.9 %
LiquidIntravenous234 mg / mL
SolutionIntravenous234 mg / mL
LiquidIntravenous.9 %
SolutionIntravenous9 mg / mL
SolutionIntravenous50 mg / mL
InjectionIntravenous; Subcutaneous0.9 g/100ml
InjectionIntravenous; Subcutaneous0.9 % w/v
LiquidParenteral9 mg / mL
SolutionIntramuscular; Intraperitoneal; Intravenous; Subcutaneous9 mg / mL
SolutionIntramuscular; Intravenous; Subcutaneous234 mg / mL
SolutionIntravenous146 mg / mL
InjectionIntravenous0.45 %
SolutionIntramuscular; Intravenous; Subcutaneous0.45 %
SolutionIntramuscular; Intravenous; Subcutaneous0.9 %
SolutionIntravenous; Subcutaneous9 mg / mL
InjectionIntravenous0.45 g/100ml
SolutionIntravenous9 g/1000ml
InjectionIntravenous3 g/100ml
LiquidIrrigation; Topical9 mg / mL
SolutionIntraperitoneal; Irrigation9 mg / mL
SolutionIntraperitoneal; Irrigation; Topical9 mg / mL
TabletOral500 mg/1
TabletIrrigation1 g / tab
TabletOral600 mg
Injection, solution, concentrateIntravenous; Subcutaneous234 mg/1mL
SolutionParenteral2 g
Powder, for solutionOral2.9 g
SolutionParenteral0.117 g
SolutionIntravenous9 mg
SolutionIntravenous0.225 g
SolutionRespiratory (inhalation)
KitIntravenous
SolutionParenteral
SolutionIntravenous0.3675 g/1000ml
Liquid; powder, for solutionIntravenous
SolutionIntrasinal; Nasal0.9 g
SolutionIntrasinal; Oral0.9 g
SolutionNasal; Respiratory (inhalation)0.009 g
SolutionNasal; Respiratory (inhalation)0.9 g
SuspensionNasal; Respiratory (inhalation)0.9 g
SolutionRespiratory (inhalation)9 mg
SolutionIntrasinal; Nasal9 mg
Powder, for solutionHemodialysis
Powder, for solutionOral50 g
TabletOral
LiquidIrrigation
SolutionConjunctival; Ophthalmic50 mg
SolutionIntravenous; Irrigation
SolutionIntraocular; Intravenous
SolutionIntravenous0.3 g
InjectionIntravenous60 g/l
SprayNasal3 g/100g
KitNasal
EnemaRectal
LiquidTopical6.5 mg/1mL
SprayNasal.65 g/100mL
KitIntramuscular; Intravenous
Granule, for solutionNasal
Solution; sprayNasal
LotionOphthalmic0.9 g/100mL
Enema
Tablet300 mg
Tablet600 mg
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US5945449No1999-08-312017-10-31US flag
US7300674No2007-11-272023-03-04US flag
US6077836No2000-06-202017-06-20US flag
US6248726No2001-06-192018-06-19US flag
US7291324No2007-11-062022-10-22US flag
US7169381No2007-01-302024-09-01US flag
US7658914No2010-02-092024-09-01US flag
US7084130No2006-08-012021-11-29US flag
US9326969No2016-05-032033-09-10US flag
US9592252No2017-03-142032-08-11US flag
US9707297No2017-07-182033-09-10US flag
US8999313No2015-04-072033-09-10US flag
US10016504No2018-07-102033-09-10US flag
US10646512No2020-05-122032-03-25US flag
US10792306No2020-10-062032-03-09US flag
US10780112No2020-09-222032-03-09US flag
US10918723No2021-02-162033-09-10US flag

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility108.0 mg/mLALOGPS
logP0.06ALOGPS
logP-0.77ChemAxon
logS0.26ALOGPS
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at October 01, 2015 19:54 / Updated at June 26, 2022 10:21