Sodium chloride
Identification
- Name
- Sodium chloride
- Accession Number
- DB09153
- Description
Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the primary salt in seawater and in the extracellular fluid of many multicellular organisms. It is listed on the World Health Organization Model List of Essential Medicines.
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Structure
Structure for Sodium chloride (DB09153)
- Weight
- Average: 58.443
Monoisotopic: 57.958622382 - Chemical Formula
- ClNa
- Synonyms
- Cloruro sódico
- Natriumchlorid
- Natrum muriaticum
- Sodium chloride
- External IDs
- B1655
- LS-1700
- NSC-77364
Pharmacology
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This intravenous solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration. Also, designed for use as a diluent and delivery system for intermittent intravenous administration of compatible drug additives.
- Associated Conditions
- Allergic Rhinitis (AR)
- Corneal Edema
- Dehydration
- Dehydration Hypertonic
- Fluid Loss
- Hemodilution
- Hypertension Intracranial
- Hypokalemia
- Hyponatremia
- Hypotonic Dehydration
- Hypovolaemia
- Inflammation of the Nasal Mucosa
- Isotonic Dehydration
- Metabolic Acidosis
- Nasal Congestion
- Nasal dryness
- Nasal irritation
- Oliguria caused by Acute Renal Failure (ARF)
- Potassium deficiency
- Sinusitis
- Skin Irritation
- Sodium Depletion
- Hypochloremic state
- Increased intraocular pressure
- Mild Metabolic acidosis
- Mild, moderate Metabolic Acidosis
- Associated Therapies
- Electrolyte replacement
- Fluid replacement therapy
- Heart-Lung-Machine
- Oral rehydration therapy
- Parenteral Nutrition
- Parenteral rehydration therapy
- Peritoneal dialysis therapy
- Plasma Volume Replacement
- Regional Citrate Anticoagulation (RCA)
- Renal Replacement Therapies
- Urine alkalinization therapy
- Wound irrigation therapy
- Ear wax removal
- Fluid and electrolyte maintenance therapy
- Increased renal excretion of toxic substances
- Maintenance source of fluid and electrolytes
- Parenteral drug administration
- Reducing brain mass
- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance, and osmotic pressure of body fluids. Sodium is also associated with chloride and bicarbonate in the regulation of the acid-base equilibrium of body fluid. Chloride, the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in the chloride concentration.
- Mechanism of action
Sodium and chloride — major electrolytes of the fluid compartment outside of cells (i.e., extracellular) — work together to control extracellular volume and blood pressure. Disturbances in sodium concentrations in the extracellular fluid are associated with disorders of water balance.
- Absorption
Absorption of sodium in the small intestine plays an important role in the absorption of chloride, amino acids, glucose, and water. Chloride, in the form of hydrochloric acid (HCl), is also an important component of gastric juice, which aids the digestion and absorption of many nutrients.
- Volume of distribution
The volume of distribution is 0.64 L/kg.
- Protein binding
Sodium is not bound by plasma proteins.
- Metabolism
The salt that is taken in to gastro intestinal tract remains for the most part unabsorbed as the liquid contents pass through the stomach and small bowel. On reaching the colon this salt, together with the water is taken in to the blood. As excesses are absorbed the kidney is constantly excreting sodium chloride, so that the chloride level in the blood and tissues remains fairly constant.Further more, if the chloride intake ceases, the kidney ceases to excrete chlorides. Body maintains an equilibrium retaining the 300gm of salt dissolved in the blood and fluid elements of the tissue dissociated into sodium ions and chloride ions.
- Route of elimination
Substantially excreted by the kidneys.
- Half-life
17 minutes
- Clearance
- Not Available
- Adverse Effects
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The rare inadvertent intravascular administration or rapid intravascular absorption of hypertonic sodium chloride can cause a shift of tissue fluids into the vascular bed, resulting in hypervolemia, electrolyte disturbances, circulatory failure, pulmonary embolism, or augmented hypertension.
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareLithium carbonate Sodium chloride may increase the excretion rate of Lithium carbonate which could result in a lower serum level and potentially a reduction in efficacy. Lithium citrate Sodium chloride may increase the excretion rate of Lithium citrate which could result in a lower serum level and potentially a reduction in efficacy. Lithium hydroxide Sodium chloride may increase the excretion rate of Lithium hydroxide which could result in a lower serum level and potentially a reduction in efficacy. Tolvaptan The risk or severity of adverse effects can be increased when Sodium chloride is combined with Tolvaptan. 
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- No interactions found.
Products
Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets- Active Moieties
Name Kind UNII CAS InChI Key Sodium cation ionic LYR4M0NH37 17341-25-2 FKNQFGJONOIPTF-UHFFFAOYSA-N Chloride ion ionic Q32ZN48698 16887-00-6 VEXZGXHMUGYJMC-UHFFFAOYSA-M - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 0.45% Sodium Chloride Injection USP Solution Intravenous B. Braun Medical Inc. 1993-12-31 Not applicable Canada 
0.9% Sodium Chloride Injection, solution 900 mg/100mL Intravenous HF Acquisition Co LLC, DBA HealthFirst 2018-10-16 Not applicable US 
0.9% Sodium Chloride Injection, solution 9 mg/1mL Intramuscular; Intravenous; Subcutaneous HF Acquisition Co LLC, DBA HealthFirst 2019-07-18 Not applicable US 0.9% Sodium Chloride Injection, solution 900 mg/100mL Intravenous HF Acquisition Co LLC, DBA HealthFirst 2020-04-07 Not applicable US 0.9% Sodium Chloride Injection, solution 900 mg/100mL Intravenous HF Acquisition Co LLC, DBA HealthFirst 2020-05-21 Not applicable US 0.9% Sodium Chloride Injection, solution 900 mg/100mL Intravenous HF Acquisition Co LLC, DBA HealthFirst 2020-04-07 Not applicable US 0.9% Sodium Chloride Irrigant 900 mg/100mL Irrigation HF Acquisition Co LLC, DBA HealthFirst 2018-10-18 Not applicable US 0.9% Sodium Chloride Injection, solution 900 mg/100mL Intravenous Sc Infomed Fluids Srl 2017-04-24 2017-04-24 US 0.9% Sodium Chloride Injection, solution 900 mg/100mL Intravenous HF Acquisition Co LLC, DBA HealthFirst 2018-10-18 Not applicable US 0.9% Sodium Chloride Injection USP Solution Intravenous B. Braun Medical Inc. 1992-12-31 Not applicable Canada - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 3% Sodium Chloride Injection, solution 3 g/100mL Intravenous Becton Dickinson and Company 2020-02-28 Not applicable US Amphenol-40 Injection, solution 9 mg/1mL Intramuscular; Intravenous; Subcutaneous It3 Medical Llc 2017-03-01 Not applicable US Bacteriostatic Sodium Chloride Injection 9 mg/1mL Intramuscular; Intravenous; Subcutaneous Fresenius Kabi USA, LLC 2000-08-08 Not applicable US Bacteriostatic Sodium Chloride Injection 9 mg/1mL Intramuscular; Intravenous; Subcutaneous Cardinal Health 2000-08-08 2016-03-31 US Corvatrol 0.9% Injection 9 mg/1mL Intramuscular; Intravenous; Subcutaneous It3 Medical Llc 2017-03-01 Not applicable US HAEMONETICS 0.9 % Sodium Chloride Solution 900 mg/100mL Extracorporeal Haemonetics Corporation 2013-01-07 Not applicable US Sodium chloride Injection, solution 9 mg/1mL Intravenous Becton Dickinson and Company 2017-09-19 Not applicable US Sodium Chloride Injection 9 mg/1mL Intravenous Fresenius Kabi USA, LLC 2000-08-10 Not applicable US Sodium Chloride Injection 9 mg/1mL Intravenous Cardinal Health 2000-08-10 2013-12-31 US Sodium Chloride Injection, solution 9 mg/1mL Intravenous Jubilant Hollisterstier Llc 2016-02-29 Not applicable US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 0.9% SODIUM CHLORIDE (500ML ROUND PLASTIC CONTAINER) Solution POLYLAB BIOTECH SDN. BHD. 2016-03-03 2019-05-10 Malaysia 
0.9% SODIUM CHLORIDE PARENTERAL SOLUTION (1000ML PLASTIC) Solution Parenteral POLYLAB BIOTECH SDN. BHD. 2017-07-04 2019-05-10 Malaysia Altachlore Sodium Chloride Hypertonicity Solution / drops 50 mg/1mL Ophthalmic Altaire Pharmaceuticals Inc. 2002-09-24 Not applicable US Ancient Secrets Breathe Again Aerosol, spray 20 mg/100mL Nasal Lotus Brands, Inc. 2011-08-15 Not applicable US Ancient Secrets Breathe Again Childrens Aerosol, spray 20 mg/100mL Nasal Lotus Brands, Inc. 2011-08-15 2015-06-01 US Aqua Maris Baby Liquid 11.25 mg/1mL Nasal Jgl North America Llc 2010-07-08 Not applicable US Aqua Maris Ear Spray 11.25 mg/1mL Auricular (otic) Jgl North America Llc 2009-10-29 Not applicable US Aqua Maris Isotonised Liquid 11.25 mg/1mL Nasal Jgl North America Llc 2001-12-28 Not applicable US Aqua Maris Throat Spray 37.5 mg/1mL Oral Jgl North America Llc 2005-04-20 Not applicable US Athomer Spray 0.9 g/100mL Nasal PHARMACOSMETIC-DIAFARM 2013-01-14 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image (20 Mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP Sodium chloride (300 mg) + Dextrose, unspecified form (3.3 g) + Potassium chloride (150 mg) Solution Intravenous Baxter Laboratories 1978-12-31 Not applicable Canada (20 Mmol/l) Potassium Chloride In 5% Dextrose and 0.9% Sodium Chloride Injection USP Sodium chloride (900 mg) + Dextrose, unspecified form (5 g) + Potassium chloride (150 mg) Solution Intravenous Baxter Laboratories 1990-12-31 Not applicable Canada (20mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP Sodium chloride (900 mg) + Potassium chloride (150 mg) Solution Intravenous Baxter Laboratories 1989-12-31 Not applicable Canada (20mmol/l) Potassium Chloride In 5% Dextrose and 0.2% Sodium Chloride Injection USP Sodium chloride (200 mg) + Dextrose, unspecified form (5 g) + Potassium chloride (150 mg) Solution Intravenous Baxter Laboratories 1989-12-31 2016-07-15 Canada (20mmol/l) Potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USP Sodium chloride (450 mg) + Dextrose, unspecified form (5 g) + Potassium chloride (150 mg) Solution Intravenous Baxter Laboratories 1989-12-31 Not applicable Canada (40 Mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP Sodium chloride (900 mg) + Potassium chloride (300 mg) Liquid Intravenous Baxter Laboratories 1989-12-31 Not applicable Canada (40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USP Sodium chloride (600 mg) + Calcium chloride (20 mg) + Sodium lactate (310 mg) + Potassium chloride (328 mg) Solution Intravenous Baxter Laboratories 2002-12-11 2016-07-15 Canada (40mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP Sodium chloride (300 mg) + Dextrose, unspecified form (3.3 g) + Potassium chloride (300 mg) Solution Intravenous Baxter Laboratories 1978-12-31 Not applicable Canada (40mmol/l)potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USP Sodium chloride (450 mg) + Dextrose, unspecified form (5 g) + Potassium chloride (300 mg) Solution Intravenous Baxter Laboratories 1989-12-31 Not applicable Canada %5 DEKSTROZ %0,2 SODYUM KLORUR COZELTISI SETLI, 100 ML Sodium chloride (5 %) + D-glucose monohydrate (0.2 %) Solution Intravenous KOÇAK FARMA İLAÇ VE KİMYA SAN. A.Ş. 2020-08-14 Not applicable Turkey 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image %0,9 IZOTONIK 1000 ML SOLUSYON(SETLI) Sodium chloride (0.9 %) Solution Intravenous POLİFARMA İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey %0,9 IZOTONIK 500 ML SOLUSYON(SETLI) Sodium chloride (0.9 %) Solution Intravenous POLİFARMA İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey %0,9 IZOTONIK 500 ML SOLUSYON(SETSIZ) Sodium chloride (0.9 %) Solution Intravenous POLİFARMA İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey %0,9 IZOTONIK SODYUM KLORUR 250 ML SOLUSYON(SETLI) Sodium chloride (0.9 %) Solution Intravenous POLİFARMA İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey %0,9 IZOTONIK SODYUM KLORUR 250 ML SOLUSYON(SETSIZ) Sodium chloride (0.9 %) Solution Intravenous POLİFARMA İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey %0,9 IZOTONIK SODYUM KLORUR ICEREN IRRIGASYON SOLUSYONU 1000 ML (POLIPROPILEN SISE) Sodium chloride (0.9 %) Solution OSEL İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey %0,9 IZOTONIK SODYUM KLORUR ICEREN IRRIGASYON SOLUSYONU 500 ML (POLIPROPILEN SISE) Sodium chloride (0.9 %) Solution OSEL İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey %0,9 SODYUM KLORUR 10 ML 10 AMPUL Sodium chloride (0.9 %) Solution Intravenous OSEL İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey %0,9 SODYUM KLORUR 250 ML SOLUSYON SETSIZ Sodium chloride (0.9 %) Solution Intravenous OSEL İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey %09 IZOTONIK 1000 ML SOLUSYON Sodium chloride (9 %) Solution Intravenous POLİFARMA İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey
Categories
- ATC Codes
- B05XA03 — Sodium chloride
- B05XA — Electrolyte solutions
- B05X — I.V. SOLUTION ADDITIVES
- B05 — BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
- B — BLOOD AND BLOOD FORMING ORGANS
- B05CB — Salt solutions
- B05C — IRRIGATING SOLUTIONS
- B05 — BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
- B — BLOOD AND BLOOD FORMING ORGANS
- Drug Categories
- Acids
- Acids, Noncarboxylic
- Alimentary Tract and Metabolism
- Anions
- Blood and Blood Forming Organs
- Blood Substitutes and Perfusion Solutions
- Chlorides
- Chlorine Compounds
- Diluents
- EENT Drugs, Miscellaneous
- Electrolyte Solutions
- Electrolytes
- I.V. Solution Additives
- Ions
- Irrigating Solutions
- Mineral Supplements
- Miscellaneous Therapeutic Agents
- Other Miscellaneous Therapeutic Agents
- Replacement Preparations
- Respiratory Agents, Miscellaneous
- Salt Solutions
- Sodium
- Sodium Compounds
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkali metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is an alkali metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkali metal salts
- Sub Class
- Alkali metal chlorides
- Direct Parent
- Alkali metal chlorides
- Alternative Parents
- Inorganic sodium salts / Inorganic chloride salts
- Substituents
- Alkali metal chloride / Inorganic chloride salt / Inorganic salt / Inorganic sodium salt
- Molecular Framework
- Not Available
- External Descriptors
- inorganic chloride, inorganic sodium salt (CHEBI:26710)
Chemical Identifiers
- UNII
- 451W47IQ8X
- CAS number
- 7647-14-5
- InChI Key
- FAPWRFPIFSIZLT-UHFFFAOYSA-M
- InChI
- InChI=1S/ClH.Na/h1H;/q;+1/p-1
- IUPAC Name
- sodium chloride
- SMILES
- [Na+].[Cl-]
References
- General References
- External Links
- AHFS Codes
- 40:50.00* — Diluents
- 52:92.00 — EENT Drugs, Miscellaneous
- 40:36.00 — Irrigating Solutions
- 92:00.00 — Miscellaneous Therapeutic Agents
- 92:92.00 — Other Miscellaneous Therapeutic Agents
- 40:12.00 — Replacement Preparations
- 48:92.00 — Respiratory Agents, Miscellaneous
- MSDS
- Download (89.8 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Active Not Recruiting Treatment Allergic Rhinitis (AR) / Pollen Allergy / Seasonal Allergic Rhinitis 1 4 Active Not Recruiting Treatment Blood Loss,Surgical 1 4 Active Not Recruiting Treatment Endothelial Dysfunction / Iron Toxicity / Oxidative Stress / Renal Anemia 1 4 Active Not Recruiting Treatment Headache 1 4 Completed Not Available Brain Swelling 1 4 Completed Not Available Colonoscopy 1 4 Completed Not Available Corneal Staining 1 4 Completed Not Available Dry Eyes 1 4 Completed Not Available Transplant, Kidney 1 4 Completed Basic Science Blood Pressures / Overdose of Beta-adrenergic Blocking Drug / Overdose, Drug 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intravenous 0.9 % Solution Intravenous 20 % Solution Intravenous 3 % Kit Irrigation; Ophthalmic; Respiratory (inhalation); Topical Kit Irrigation; Ophthalmic; Topical Kit Irrigation; Oral; Respiratory (inhalation); Topical Kit Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical Solution Solution Hemodialysis 0.257 g/1000ml Kit Intradermal; Subcutaneous Solution Topical Solution; spray Nasal Solution Irrigation; Parenteral Powder, for solution Intraocular Solution Intraocular Aerosol, spray Nasal 20 mg/100mL Liquid Topical Liquid Nasal 11.25 mg/1mL Spray Auricular (otic) 11.25 mg/1mL Spray Oral 37.5 mg/1mL Spray Nasal 0.9 mg/100mL Spray Nasal 0.9 g/100mL Inhalant Respiratory (inhalation) 1.7 mg/1mL Solution Intravenous drip Liquid Respiratory (inhalation) Solution Ophthalmic Solution / drops Nasal Kit; powder, for solution; tablet, delayed release Oral Kit; powder, for solution Hemodialysis Liquid; powder, for solution Subcutaneous Liquid Oral 0.5 g/100mL Solution / drops; suspension / drops Aerosol, metered Respiratory (inhalation) Kit; solution Intraocular Liquid Ophthalmic Liquid Topical 0.495 g/50mL Liquid Topical 0.99 g/100mL Liquid Topical 2.97 g/300mL Liquid Topical 4.95 g/500mL Powder Topical 60 g/300g Solution Intra-arterial Solution Nasal; Ophthalmic 900 mg/100mL Swab Topical 0.9 g/100mL Liquid Nasal 6.5 mg/1mL Injection, solution Parenteral Solution Intramuscular; Intravenous; Subcutaneous Solution Intravenous; Irrigation Solution Intravenous 0.9 % w/v Powder, for solution Nasogastric Solution, concentrate Hemodialysis Injection, powder, lyophilized, for solution Hemodialysis Liquid Ophthalmic Liquid Epidural; Infiltration; Subcutaneous Ointment Topical Solution Ophthalmic Powder Nasal Spray Nasal 0.9 g/100g Solution Irrigation Paste, dentifrice Oral Solution Intraperitoneal Solution Parenteral Liquid Intravenous Injection Intravenous Liquid Topical Solution Intraperitoneal; Irrigation Injection, solution Intraperitoneal Injection Subcutaneous 4.5 mg/0.5mL Liquid Intradermal; Percutaneous; Subcutaneous Liquid Subcutaneous Solution Intravenous 1.47 mg/1ml Kit Epidural; Infiltration; Intracaudal; Subcutaneous; Topical Injection, solution, concentrate Intramuscular Spray Topical Spray Nasal 0.39 mL/60mL Solution Intravenous 4.21 g/1000ml Kit Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical Granule, for solution Oral Injection, solution Solution Intrathecal Injection Intrathecal Solution Intravenous; Subcutaneous Powder Oral Solution Rectal Enema; kit; tablet Rectal Spray Nasal 30 mg/1mL Kit Epidural; Infiltration Solution Nasal 0.29 mg/44mL Kit; liquid; powder, for solution Intramuscular; Subcutaneous Liquid; powder, for solution Intramuscular; Subcutaneous Solution Irrigation; Topical Liquid Topical 1.5 g/100mL Solution Intra-articular; Irrigation Spray Oral Aerosol, spray Oral Powder, for solution Nasogastric; Oral Solution Extracorporeal 9 g Solution Extracorporeal 900 mg/100mL Solution Extracorporeal Liquid Hemodialysis Solution Oral Solution Ophthalmic 50 mg Solution Nasal Liquid; powder, for solution Intramuscular Solution Intrasinal; Nasal Liquid Nasal .65 g/100mL Injection Intravenous Liquid Intraperitoneal Solution Hemodialysis; Intraperitoneal Liquid Intravesical Injection Parenteral Liquid Intraocular Solution Intravenous Solution Parenteral Solution Intravenous Kit Intravenous; Topical Irrigant Irrigation Solution Intravenous 1000 ml Solution Intravenous 150 ml Solution Intravenous 250 ml Solution Intravenous 50 ml Solution Intravenous 500 ml Solution Intravenous 100 ml Liquid Infiltration; Subcutaneous; Topical Tablet Vaginal Solution, for slush Irrigation Solution Intravenous; Irrigation Gel Vaginal Solution / drops Ophthalmic Solution Conjunctival; Ophthalmic Injection, solution Powder, for solution Subcutaneous Liquid Buccal Spray Buccal Powder, for solution Oral 13.125 g Injection, solution, concentrate Oral Kit Oral Injection, solution Hemodialysis; Intravenous Solution Ophthalmic 20 mg/1mL Solution Ophthalmic 50 mg/1mL Liquid Intraocular; Ophthalmic Solution Intravenous 117 mg Lotion Topical .65 mL/100mL Solution Intrasinal; Nasal 0.9 g Spray Nasal 9.5 mg/1mL Spray Nasal 2600 mg/100mL Solution Intrasinal; Nasal 9 mg Solution Nasal; Respiratory (inhalation) Solution Intrasinal; Nasal 6.5 mg Spray Nasal 3 mL/100mL Spray Nasal 1.2 mg/10mL Injection, solution Intravenous Injection, solution Parenteral Kit; solution Intraocular; Irrigation Tablet Oral 1 g/1 Injection, emulsion Intravenous Emulsion Parenteral Emulsion Intravenous Injection, solution, concentrate Intravenous Solution, concentrate Oral Solution Intraocular; Ophthalmic Liquid; mouthwash Oral Solution Extracorporeal; Intrabiliary; Intracardiac Solution Auricular (otic) Liquid Intradermal; Subcutaneous Solution Intrasinal; Nasal 0.65 g Solution Irrigant Irrigation Injection, solution Intravenous Injection, solution Intra-arterial Powder, for solution Oral Kit Hemodialysis Solution Hemodialysis; Intravenous Solution Hemodialysis Enema Rectal Douche Vaginal Powder, for solution Intravenous Patch Transdermal 0.03 g/1g Kit; liquid; powder Intralesional; Subcutaneous Injection, solution Extracorporeal Liquid; powder, for solution Intravenous; Subcutaneous Solution Intravenous 0.1 g/500ml Solution Irrigation; Topical Solution Unknown Powder, for solution Intramuscular; Subcutaneous Spray Nasal 6.5 mg/1mL Spray Oral 6.5 mg/1mL Spray Nasal 2.65 mg/100mL Liquid Nasal Cloth Topical 0.9 g/100mL Gel Nasal Spray Nasal Aerosol Oral Powder Topical Injection, solution Intravenous 0.9 % Injection Intravenous 0.9 % Liquid Epidural Powder, for solution Nasal Solution Irrigation; Parenteral Solution Irrigation Injection, solution Irrigation Injection, solution, concentrate Intravenous Solution, concentrate Intravenous Solution, concentrate Parenteral Powder Hemodialysis Inhalant Respiratory (inhalation) 0.9 mg/100mL Injection Injection Intramuscular; Intravenous; Subcutaneous 0.9 mg/10mL Injection Intramuscular; Intravenous; Subcutaneous 234 mg/1mL Injection Intramuscular; Intravenous; Subcutaneous 9 mg/1mL Injection Intravascular .9 mg/1mL Injection Intravenous 0.45 g/50mL Injection Intravenous 0.9 g/100mL Injection Intravenous 450 mg/100mL Injection Intravenous 450 mg/50mL Injection Intravenous 9 mg/1mL Injection Intravenous 900 mg/100mL Injection Intravenous 900 mg/1000mL Injection, solution Intramuscular; Intravenous; Subcutaneous 234 mg/1mL Injection, solution Intramuscular; Intravenous; Subcutaneous 9 mg/1mL Injection, solution Intravenous 0.45 g/100mL Injection, solution Intravenous 0.9 g/100mL Injection, solution Intravenous 146 mg/1mL Injection, solution Intravenous 234 mg/1mL Injection, solution Intravenous 3 g/100mL Injection, solution Intravenous 4.5 g/1000mL Injection, solution Intravenous 450 mg/100mL Injection, solution Intravenous 450 mg/50mL Injection, solution Intravenous 5 g/100mL Injection, solution Intravenous 9 g/1 Injection, solution Intravenous 9 mg/1mL Injection, solution Intravenous 9 g/1000mL Injection, solution Intravenous 900 mg/100mL Injection, solution, concentrate Intravenous 2.92 g/20mL Injection, solution, concentrate Intravenous 234 mg/1mL Injection, solution, concentrate Intravenous 5.84 g/40mL Irrigant Irrigation 0.9 g/100mL Irrigant Irrigation 450 mg/100mL Irrigant Irrigation 9 g/1000mL Irrigant Irrigation 900 mg/100mL Ointment Ophthalmic 50 mg/1g Solution Intravenous 0.45 g/100mL Solution Intravenous 0.9 g/100mL Solution Respiratory (inhalation) 0.027 mg/3mL Solution / drops Ophthalmic 50 mg/1mL Liquid Intravenous Solution Ophthalmic 0.9 g/100mL Liquid Intravenous; Subcutaneous Liquid Intramuscular; Intravenous; Subcutaneous Solution Irrigation 0.9 g/100mL Inhalant Respiratory (inhalation) 9 g/1L Liquid Parenteral Solution Intramuscular; Intraperitoneal; Intravenous; Subcutaneous Solution Intravenous; Subcutaneous Liquid Irrigation; Topical Solution Intraperitoneal; Irrigation Solution Intraperitoneal; Irrigation; Topical Tablet Oral 500 mg/1 Tablet Irrigation Tablet Oral Injection, solution, concentrate Intravenous; Subcutaneous 234 mg/1mL Solution Conjunctival; Ophthalmic Solution Respiratory (inhalation) Kit Intravenous Solution Intraocular; Irrigation Liquid; powder, for solution Intravenous Solution Intrasinal; Oral Suspension Nasal; Respiratory (inhalation) Solution Respiratory (inhalation) Solution Parenteral 0.9 g Liquid Oral Powder, for solution Hemodialysis Powder, for solution Oral Tablet Oral Liquid Irrigation Solution Intraocular; Intravenous Spray Nasal 3 g/100g Kit Nasal Enema Rectal Liquid Topical 6.5 mg/1mL Spray Nasal .65 g/100mL Kit Intramuscular; Intravenous Granule, for solution Nasal Spray Nasal Solution; spray Nasal Lotion Ophthalmic Enema Tablet - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US5945449 No 1999-08-31 2017-10-31 US US7300674 No 2007-11-27 2023-03-04 US US6077836 No 2000-06-20 2017-06-20 US US6248726 No 2001-06-19 2018-06-19 US US7291324 No 2007-11-06 2022-10-22 US US7169381 No 2007-01-30 2024-09-01 US US7658914 No 2010-02-09 2024-09-01 US US7084130 No 2006-08-01 2021-11-29 US US9326969 No 2016-05-03 2033-09-10 US US9592252 No 2017-03-14 2032-08-11 US US9707297 No 2017-07-18 2033-09-10 US US8999313 No 2015-04-07 2033-09-10 US US10016504 No 2018-07-10 2033-09-10 US US10646512 No 2012-03-25 2032-03-25 US US10792306 No 2012-03-09 2032-03-09 US US10780112 No 2012-03-09 2032-03-09 US US10918723 No 2013-09-10 2033-09-10 US
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 108.0 mg/mL ALOGPS logP 0.06 ALOGPS logP -0.77 ChemAxon logS 0.26 ALOGPS pKa (Strongest Acidic) 3.09 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 0 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 0 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 0 m3·mol-1 ChemAxon Polarizability 1.78 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created on October 01, 2015 19:54 / Updated on April 23, 2021 04:04