Sodium chloride

Identification

Name
Sodium chloride
Accession Number
DB09153
Description

Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the primary salt in seawater and in the extracellular fluid of many multicellular organisms. It is listed on the World Health Organization Model List of Essential Medicines.

Type
Small Molecule
Groups
Approved, Vet approved
Structure
Thumb
Weight
Average: 58.443
Monoisotopic: 57.958622382
Chemical Formula
ClNa
Synonyms
  • Cloruro sódico
  • Natriumchlorid
  • Natrum muriaticum
External IDs
  • B1655
  • LS-1700
  • NSC-77364

Pharmacology

Indication

This intravenous solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration. Also, designed for use as a diluent and delivery system for intermittent intravenous administration of compatible drug additives.

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics

Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance, and osmotic pressure of body fluids. Sodium is also associated with chloride and bicarbonate in the regulation of the acid-base equilibrium of body fluid. Chloride, the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in the chloride concentration.

Mechanism of action

Sodium and chloride — major electrolytes of the fluid compartment outside of cells (i.e., extracellular) — work together to control extracellular volume and blood pressure. Disturbances in sodium concentrations in the extracellular fluid are associated with disorders of water balance.

Absorption

Absorption of sodium in the small intestine plays an important role in the absorption of chloride, amino acids, glucose, and water. Chloride, in the form of hydrochloric acid (HCl), is also an important component of gastric juice, which aids the digestion and absorption of many nutrients.

Volume of distribution

The volume of distribution is 0.64 L/kg.

Protein binding

Sodium is not bound by plasma proteins.

Metabolism

The salt that is taken in to gastro intestinal tract remains for the most part unabsorbed as the liquid contents pass through the stomach and small bowel. On reaching the colon this salt, together with the water is taken in to the blood. As excesses are absorbed the kidney is constantly excreting sodium chloride, so that the chloride level in the blood and tissues remains fairly constant.Further more, if the chloride intake ceases, the kidney ceases to excrete chlorides. Body maintains an equilibrium retaining the 300gm of salt dissolved in the blood and fluid elements of the tissue dissociated into sodium ions and chloride ions.

Route of elimination

Substantially excreted by the kidneys. (drugs.com)

Half-life

17 minutes.

Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity

The rare inadvertent intravascular administration or rapid intravascular absorption of hypertonic sodium chloride can cause a shift of tissue fluids into the vascular bed, resulting in hypervolemia, electrolyte disturbances, circulatory failure, pulmonary embolism, or augmented hypertension. ( toxnet)

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Lithium carbonateSodium chloride may increase the excretion rate of Lithium carbonate which could result in a lower serum level and potentially a reduction in efficacy.
Lithium citrateSodium chloride may increase the excretion rate of Lithium citrate which could result in a lower serum level and potentially a reduction in efficacy.
Lithium hydroxideSodium chloride may increase the excretion rate of Lithium hydroxide which could result in a lower serum level and potentially a reduction in efficacy.
TolvaptanThe risk or severity of adverse effects can be increased when Sodium chloride is combined with Tolvaptan.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
No interactions found.

Products

Active Moieties
NameKindUNIICASInChI Key
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Chloride ionionicQ32ZN4869816887-00-6VEXZGXHMUGYJMC-UHFFFAOYSA-M
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
0.45% Sodium Chloride Injection USPSolutionIntravenousB. Braun Medical Inc.1993-12-31Not applicableCanada flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2020-05-21Not applicableUS flag
0.9% Sodium ChlorideInjection, solution9 mg/1mLIntramuscular; Intravenous; SubcutaneousHF Acquisition Co LLC, DBA HealthFirst2019-07-18Not applicableUS flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2020-04-07Not applicableUS flag
0.9% Sodium ChlorideIrrigant900 mg/100mLIrrigationHF Acquisition Co LLC, DBA HealthFirst2018-10-18Not applicableUS flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousSc Infomed Fluids Srl2017-04-242017-04-24US flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2018-10-18Not applicableUS flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2018-10-16Not applicableUS flag
0.9% Sodium ChlorideInjection, solution900 mg/100mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2020-04-07Not applicableUS flag
0.9% Sodium Chloride Injection USPSolutionIntramuscular; Intravenous; SubcutaneousOmega Laboratories Ltd1977-12-31Not applicableCanada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
3% Sodium ChlorideInjection, solution3 g/100mLIntravenousBecton Dickinson and Company2020-02-28Not applicableUS flag
Amphenol-40Injection, solution9 mg/1mLIntramuscular; Intravenous; SubcutaneousIt3 Medical Llc2017-03-01Not applicableUS flag
Bacteriostatic Sodium ChlorideInjection9 mg/1mLIntramuscular; Intravenous; SubcutaneousFresenius Kabi USA, LLC2000-08-08Not applicableUS flag
Bacteriostatic Sodium ChlorideInjection9 mg/1mLIntramuscular; Intravenous; SubcutaneousCardinal Health2000-08-082016-03-31US flag
Corvatrol 0.9%Injection9 mg/1mLIntramuscular; Intravenous; SubcutaneousIt3 Medical Llc2017-03-01Not applicableUS flag
HAEMONETICS 0.9 % Sodium ChlorideSolution900 mg/100mLExtracorporealHaemonetics Corporation2013-01-07Not applicableUS flag
Sodium ChlorideInjection, solution450 mg/100mLIntravenousBecton Dickinson and Company2018-07-23Not applicableUS flag
Sodium ChlorideInjection, solution9 g/1mLIntravenousNextgen Pharmaceuticals LLC2020-07-01Not applicableUS flag
Sodium ChlorideInjection900 mg/100mLIntravenousFresenius Medical Care North America2007-04-12Not applicableUS flag
Sodium ChlorideInjection9 mg/1mLIntramuscular; Intravenous; SubcutaneousWest-ward Pharmaceutical Corp.2013-09-242014-08-12US flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Altachlore Sodium Chloride HypertonicitySolution / drops50 mg/1mLOphthalmicAltaire Pharmaceuticals Inc.2002-09-24Not applicableUS flag
Ancient Secrets Breathe AgainAerosol, spray20 mg/100mLNasalLotus Brands, Inc.2011-08-15Not applicableUS flag
Ancient Secrets Breathe Again ChildrensAerosol, spray20 mg/100mLNasalLotus Brands, Inc.2011-08-152015-06-01US flag
Aqua Maris BabyLiquid11.25 mg/1mLNasalJgl North America Llc2010-07-08Not applicableUS flag
Aqua Maris EarSpray11.25 mg/1mLAuricular (otic)Jgl North America Llc2009-10-29Not applicableUS flag
Aqua Maris IsotonisedLiquid11.25 mg/1mLNasalJgl North America Llc2001-12-28Not applicableUS flag
Aqua Maris ThroatSpray37.5 mg/1mLOralJgl North America Llc2005-04-20Not applicableUS flag
AthomerSpray0.9 g/100mLNasalPHARMACOSMETIC-DIAFARM2013-01-14Not applicableUS flag
Athomer babySpray0.9 g/100mLNasalPHARMACOSMETIC-DIAFARM2013-01-14Not applicableUS flag
Athomer miniSpray0.9 g/100mLNasalPHARMACOSMETIC-DIAFARM2013-01-14Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
(20 Mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USPSodium chloride (300 mg) + Dextrose, unspecified form (3.3 g) + Potassium chloride (150 mg)SolutionIntravenousBaxter Laboratories1978-12-31Not applicableCanada flag
(20 Mmol/l) Potassium Chloride In 5% Dextrose and 0.9% Sodium Chloride Injection USPSodium chloride (900 mg) + Dextrose, unspecified form (5 g) + Potassium chloride (150 mg)SolutionIntravenousBaxter Laboratories1990-12-31Not applicableCanada flag
(20mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USPSodium chloride (900 mg) + Potassium chloride (150 mg)SolutionIntravenousBaxter Laboratories1989-12-31Not applicableCanada flag
(20mmol/l) Potassium Chloride In 5% Dextrose and 0.2% Sodium Chloride Injection USPSodium chloride (200 mg) + Dextrose, unspecified form (5 g) + Potassium chloride (150 mg)SolutionIntravenousBaxter Laboratories1989-12-312016-07-15Canada flag
(20mmol/l) Potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USPSodium chloride (450 mg) + Dextrose, unspecified form (5 g) + Potassium chloride (150 mg)SolutionIntravenousBaxter Laboratories1989-12-31Not applicableCanada flag
(40 Mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USPSodium chloride (900 mg) + Potassium chloride (300 mg)LiquidIntravenousBaxter Laboratories1989-12-31Not applicableCanada flag
(40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USPSodium chloride (600 mg) + Calcium chloride (20 mg) + Sodium lactate (310 mg) + Potassium chloride (328 mg)SolutionIntravenousBaxter Laboratories2002-12-112016-07-15Canada flag
(40mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USPSodium chloride (300 mg) + Dextrose, unspecified form (3.3 g) + Potassium chloride (300 mg)SolutionIntravenousBaxter Laboratories1978-12-31Not applicableCanada flag
(40mmol/l)potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USPSodium chloride (450 mg) + Dextrose, unspecified form (5 g) + Potassium chloride (300 mg)SolutionIntravenousBaxter Laboratories1989-12-31Not applicableCanada flag
0.15% Potassium Chloride In 3.3% Dextrose and 0.30% Sodium Chloride InjectionSodium chloride (300 mg) + Dextrose, unspecified form (3.3 g) + Potassium chloride (150 mg)SolutionIntravenousB. Braun Medical Inc.1992-12-31Not applicableCanada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
0.9% Sodium ChlorideSodium chloride (900 mg/100mL)Injection, solutionIntravenousSc Infomed Fluids Srl2017-04-242017-04-24US flag
4381 First Aid KitSodium chloride (0.9 g/100mL) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (62 mL/100mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitIrrigation; Ophthalmic; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
4382 First Aid KitSodium chloride (0.9 g/100mL) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (62 mL/100mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitIrrigation; Ophthalmic; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
4383 First Aid KitSodium chloride (0.9 g/100mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (62 mL/100mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitIrrigation; Ophthalmic; TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
4384 First Aid KitSodium chloride (0.9 g/100mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (62 mL/100mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitIrrigation; Ophthalmic; TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
4385 First Aid KitSodium chloride (0.9 g/100mL) + Ethanol (665 mL/1L) + Isopropyl alcohol (0.7 mL/1mL) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)Irrigation; Ophthalmic; TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
4386 First Aid KitSodium chloride (0.9 g/100mL) + Ethanol (665 mL/1L) + Isopropyl alcohol (0.7 mL/1mL) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)Irrigation; Ophthalmic; TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
4387 First Aid KitSodium chloride (0.9 g/100mL) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (665 mL/1L) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL)Irrigation; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
4388 First Aid KitSodium chloride (0.9 g/100mL) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (665 mL/1L) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)Irrigation; Ophthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
4393 First Aid KitSodium chloride (0.9 g/100mL) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (62 mL/100mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)Irrigation; Ophthalmic; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag

Categories

ATC Codes
B05XA03 — Sodium chlorideB05CB01 — Sodium chlorideA12CA01 — Sodium chloride
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkali metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal salts
Sub Class
Alkali metal chlorides
Direct Parent
Alkali metal chlorides
Alternative Parents
Inorganic sodium salts / Inorganic chloride salts
Substituents
Alkali metal chloride / Inorganic chloride salt / Inorganic salt / Inorganic sodium salt
Molecular Framework
Not Available
External Descriptors
inorganic chloride, inorganic sodium salt (CHEBI:26710)

Chemical Identifiers

UNII
451W47IQ8X
CAS number
7647-14-5
InChI Key
FAPWRFPIFSIZLT-UHFFFAOYSA-M
InChI
InChI=1S/ClH.Na/h1H;/q;+1/p-1
IUPAC Name
sodium chloride
SMILES
[Na+].[Cl-]

References

General References
  1. ChemIDplus [Link]
  2. Pubchem [Link]
KEGG Drug
D02056
KEGG Compound
C13563
PubChem Compound
5234
PubChem Substance
310265066
ChemSpider
5044
BindingDB
50098543
RxNav
9863
ChEBI
26710
ChEMBL
CHEMBL1200574
PharmGKB
PA451382
Wikipedia
Sodium_chloride
AHFS Codes
  • 40:50.00* — Diluents
  • 52:92.00 — EENT Drugs, Miscellaneous
  • 40:36.00 — Irrigating Solutions
  • 92:00.00 — Miscellaneous Therapeutic Agents
  • 92:92.00 — Other Miscellaneous Therapeutic Agents
  • 40:12.00 — Replacement Preparations
  • 48:92.00 — Respiratory Agents, Miscellaneous
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingTreatmentAbdominal Wall Hernia / Bowel Diseases / Gastric Diseases / Pancreatic Diseases1
4Active Not RecruitingTreatmentBlood Loss,Surgical1
4Active Not RecruitingTreatmentEndothelial Dysfunction / Iron Toxicity / Oxidative Stress / Renal Anemia1
4Active Not RecruitingTreatmentImpaired kidney function1
4CompletedNot AvailableBrain Swelling1
4CompletedNot AvailableColonoscopy1
4CompletedNot AvailableCorneal Staining1
4CompletedNot AvailableDry Eyes1
4CompletedNot AvailableTransplant, Kidney1
4CompletedBasic ScienceBlood Pressures / Overdose of Beta-adrenergic Blocking Drug / Overdose, Drug1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Solution0.9 %
Solution20 %
SolutionIntravenous0.9 %
SolutionIntravenous9 %
Solution3 %
SolutionIntravenous5 %
Injection, solutionIntravenous150 mg/100mL
Injection, solutionIntravenous300 mg/100mL
SolutionIntramuscular; Intravenous; Subcutaneous
SolutionIntravenous
SolutionIntravenous3.3 g/100mL
SolutionIntravenous3.75 g/100mL
SolutionIntravenous3.2 g/100mL
SolutionIrrigation
KitIrrigation; Ophthalmic; Respiratory (inhalation); Topical
KitIrrigation; Ophthalmic; Topical
Injection, solution257 mg/1L
SolutionTopical200 mcL/100mL
SolutionRespiratory (inhalation)
KitIntradermal; Subcutaneous
Injection, solutionIntravenous2.5 g/500mL
Powder, for solutionIntraocular
SolutionIntraocular
Aerosol, sprayNasal20 mg/100mL
LiquidTopical
LiquidNasal11.25 mg/1mL
SprayAuricular (otic)11.25 mg/1mL
SprayOral37.5 mg/1mL
SolutionOral289.2 mg
SprayNasal0.9 g/100mL
SolutionIntraperitoneal951 mg/L
LiquidRespiratory (inhalation)
SolutionIntraperitoneal0.1838 g/L
SolutionIntraperitoneal0.2573 g/L
SolutionOphthalmic
SolutionIntraocular; Irrigation1950 mg
Powder, for solutionHemodialysis
Solution / dropsNasal0.9 %
Solution; sprayNasal0.9 %
Kit; powder, for solution; tablet, delayed releaseOral
Kit; powder, for solutionHemodialysis
Liquid; powder, for solutionSubcutaneous
SolutionIntravenous3 %
Solution5 %
Solution10 g/L
SolutionIntravenous0.64 g/100ml
SolutionIntravenous5 g/100ml
SolutionIntravenous0.86 g/100ml
SolutionIntravenous3 g/L
SolutionIntravenous3.1 g/L
Injection, solutionIntravenous3.1 g/L
LiquidOral0.5 g/100mL
Solution / drops; suspension / drops
SprayNasal
Aerosol, meteredRespiratory (inhalation)
SolutionIrrigation48 mg/100mL
Kit; solutionIntraocular
LiquidTopical0.495 g/50mL
LiquidTopical0.99 g/100mL
LiquidTopical2.97 g/300mL
LiquidTopical4.95 g/500mL
PowderTopical60 g/300g
SolutionIntraperitoneal0.0003 g
SolutionIntra-arterial
Solution6340 mg/L
SolutionNasal
SolutionNasal; Ophthalmic900 mg/100mL
Powder, for solutionNasal990 mg
SwabTopical0.9 g/100mL
LiquidNasal6.5 mg/1mL
SolutionIntravenous1.491 g
SolutionIntramuscular; Intravenous; Subcutaneous9 mg
SolutionIntrasinal; Nasal9 mg
SolutionIntravenous; Irrigation9 mg
SolutionIntravenous20 mEq
SolutionIntravenous900 mg
SolutionIntravenous1.1688 g
SolutionIntravenous0.9 % w/v
SolutionIntravenous0.009 g
SolutionIntravenous116.9 mg
Powder, for solutionNasogastric
Powder, for solutionOral45 g/750mL
Solution, concentrateHemodialysis99 g
LiquidEpidural; Infiltration; Subcutaneous
OintmentTopical
SolutionTopical
SolutionOphthalmic5 %
PowderNasal
SolutionIrrigation
SolutionIntraperitoneal
SolutionIntravenous6.4 g/L
Injection, solutionIntravenous10 g/100mL
SolutionIntravenous0.45 g
SolutionIntravenous9 mg
LiquidIntravenous
InjectionIntravenous
LiquidTopical
Injection, solutionIntraperitoneal220 mg
SolutionIntraperitoneal; Irrigation18.3 mg
SolutionIntraperitoneal18.3 mg
Injection, solutionIntraperitoneal
LiquidHemodialysis
SolutionHemodialysis
Injection, solutionIntraperitoneal18.3 mg/100mL
Solution22.7 g/L
Solution13.6 g/L
SolutionIntraperitoneal22.7 g/L
Solution38.6 g/L
SolutionIntraperitoneal13.6 g/L
SolutionIntraperitoneal38.6 g/L
InjectionSubcutaneous4.5 mg/0.5mL
LiquidIntradermal; Percutaneous; Subcutaneous
LiquidSubcutaneous
KitEpidural; Infiltration; Intracaudal; Subcutaneous; Topical
SprayTopical
SprayNasal0.39 mL/60mL
Solution / dropsNasal180 mg/20ml
SolutionIntravenous4.21 g/1000ml
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical
LiquidOphthalmic
SolutionOral12.27 g/100mL
PowderOral
Injection, solutionIntravenous3.38 g
SolutionIntrathecal
InjectionIntrathecal
PowderOral52.5 g
SolutionRectal2.5 g
Powder, for solutionOral2.9 g
SolutionOral0.294 g
Enema; kit; tabletRectal
SprayNasal30 mg/1mL
Solution / dropsNasal500 mg/100mL
Solution / dropsNasal1 g/100mL
KitEpidural; Infiltration
SolutionIntraperitoneal0.0257 g
Solution75 g/L
Injection, solutionIntraperitoneal25.7 mg/100mL
SolutionIntraperitoneal7.5 g/100mL
SolutionNasal0.29 mg/44mL
Kit; liquid; powder, for solutionIntramuscular; Subcutaneous
Liquid; powder, for solutionIntramuscular; Subcutaneous
LiquidTopical1.5 g/100mL
InjectionIntravenous20 g
SolutionIntravenous1.63 g
PowderOral13.5 g
SprayOral7.3 mg/50mL
Powder, for solutionNasogastric; Oral
SolutionExtracorporeal9 g
SolutionExtracorporeal900 mg/100mL
SolutionExtracorporeal
Powder, for solutionNasal1.7 g
Solution, concentrate9 g/1L
Solution, concentrate6.43 g/1L
Tablet600 mg
SolutionOral369 mg
SolutionOral216 mg
SolutionOral30 mg
SolutionOral0.29 g
SolutionOral0.275 g
SolutionOral275 mg
SolutionOphthalmic50 mg
Liquid; powder, for solutionIntramuscular
SolutionIntrasinal; Nasal0.9 g
SolutionIntravenous6 %
SolutionIntravenous3 g
SolutionIntravenous0.31 %
SolutionIntraperitoneal7.5 %
Solution; sprayNasal6.25 mg/1mL
LiquidNasal.65 g/100mL
InjectionIntravenous
LiquidIntraperitoneal
SolutionHemodialysis; Intraperitoneal
LiquidIntravesical
SolutionIntravenous0.02 g
LiquidIntraocular
Solution0.64 g/100ml
InjectionIntravenous3.33 %
SolutionIntravenous0.64 %
SolutionIntravenous0.03 %
SolutionIntravenous0.37 %
SolutionIntravenous
KitIntravenous; Topical
SolutionIntravenous2.5 %
SolutionIntravenous3.33 %
SolutionIntravenous3.75 %
IrrigantIrrigation0.9 %
InjectionIntravenous0.9 %
Solution1000 ml
Solution150 ml
Solution250 ml
Solution50 ml
Solution500 ml
Solution100 ml
Solution3000 ml
LiquidInfiltration; Subcutaneous; Topical
TabletVaginal
SolutionIntravenous0.07 g
SolutionIntravenous8.6 %
Powder, for solutionOral1.685 g
SolutionIntravenous20.475 %
Injection, solutionIntravenous30 mg/100mL
Solution, for slushIrrigation
SolutionIntravenous20 mg
SolutionIntravenous; Irrigation0.2 mg
GelVaginal
SolutionIntravenous0.45 %
SolutionIntravenous30 mg/mL
Injection, solutionIntravenous50 mg/mL
SolutionIntravenous50 mg/mL
SolutionIntravenous0.3 %
Injection, solutionIntravenous3 g/L
Injection, solutionIntravenous3.14 g/L
Solution / dropsOphthalmic0.9 %
Injection, solution20 mg/2ml
Injection, solutionIntravenous6 g/100mL
PowderOral3.5 g
PowderOral5 g/100mL
Powder, for solutionOral13.125 G
Powder, for solutionSubcutaneous
LiquidBuccal
SprayBuccal
SolutionOral13.125 g
Powder, for solutionOral6.563 G
KitOral
SolutionOral100 g
SolutionIntravenous0.368 g
SolutionOphthalmic20 mg/1mL
SolutionOphthalmic50 mg/1mL
LiquidIntraocular; Ophthalmic
SolutionIntravenous117 mg
LotionTopical.65 mL/100mL
Capsule650 mg
Injection, solutionIntravenous20 g/100mL
Injection, solution3 g/100mL
Solution / dropsOphthalmic5 g/100mL
Solution / dropsNasal900 mg/100mL
SprayNasal9.5 mg/1mL
SprayNasal2600 mg/100mL
Solution; sprayNasal650 mg/100mL
Solution; sprayNasal1 g/100mL
SolutionIntrasinal; Nasal1 mL
SprayNasal3 mL/100mL
SprayNasal1.2 mg/10mL
Injection, solutionParenteral9 mg/ml
Kit; solutionIntraocular; Irrigation
InjectionIntravenous3.33 g/100ml
Injection, solutionIntravenous33.3 g/L
SolutionIntravenous55 g/L
Solution0.53 g/100ml
SolutionIntravenous0.86 %
Injection, solutionIntravenous60 g/1000ml
Powder, for solutionOral118 g
Mouthwash900 mg/100mL
TabletOral1 g/1
Injection, solution900 mg/100mL
Solution; sprayNasal900 mg/100mL
EmulsionIntravenous1.83 g
InjectionIntravenous1.03 g
EmulsionIntravenous20 mg
EmulsionIntravenous16 g
Injection, solution, concentrateIntravenous
SolutionIntraperitoneal510 mg/l
SolutionOral
SolutionIntraocular; Ophthalmic7.8 mg
LotionOphthalmic900 mg/100mL
LotionOphthalmic1.24 g/100mL
Liquid; mouthwash
SolutionAuricular (otic)0.06 g
Powder, for solutionOral59 g
Injection, solutionIntraperitoneal32 mg/100mL
SolutionOral108.2 mg
SolutionOral294 mg
SolutionOral29.4 mg
Powder, for solutionOral120 g/129.2g
Injection, solutionIntravenous5 %
Injection, solutionIntravenous3.75 %
Injection, solutionIntravenous10 %
LiquidIntradermal; Subcutaneous
SolutionIntrasinal; Nasal0.65 g
SolutionIntraperitoneal15 g/L
SolutionIntraperitoneal25 g/L
SolutionIntravenous25 g/L
SolutionIntraperitoneal42.5 g/L
IrrigantIrrigation
SolutionIntravenous368 mg
Injection, solutionIntravenous
Injection, solutionIntra-arterial
Solution
Injection, solutionIntravenous0.45 %
Injection, solutionIntravenous0.9 %
SolutionIntravenous1 %
SolutionIntravenous0.035 %
Injection, solutionIntravenous0.03 %
Powder, for solutionOral
KitHemodialysis
SolutionHemodialysis; Intravenous
Injection, solution514.5 mg/100mL
Injection, solutionIntravenous0.86 g/100mL
SolutionParenteral3 g/100ml
DoucheVaginal
Powder, for solutionIntravenous
Powder, for solutionTopical4.5 g
PatchTransdermal0.03 g/1g
Kit; liquid; powderIntralesional; Subcutaneous
Injection, solutionExtracorporeal
Liquid; powder, for solutionIntravenous; Subcutaneous
SolutionIrrigation4.75 mL/100mL
SolutionIntravenous0.6 g/100ml
SolutionIrrigation; Topical20 mg
Injection, solutionIntravenous20 mg/100mL
Injection, solution20 mg/100mL
SolutionUnknown
Powder, for solutionIntramuscular; Subcutaneous
SprayNasal6.5 mg/1mL
SprayOral6.5 mg/1mL
SprayNasal2.65 mg/100mL
LiquidNasal
ClothTopical0.9 g/100mL
GelNasal
SprayNasal
AerosolOral
SolutionOral1 g/100mL
Powder, for solutionOral10 g
PowderTopical
SolutionNasal20 ml
Injection0.9 %
InjectionIntravenous0.09 %
SolutionOral70 mg/1mL
LiquidEpidural
Powder, for solutionNasal
MouthwashOral3 mg/100mL
SolutionIntravenous2.25 g
SolutionIrrigation0.9 g
SolutionIntravenous9 g/l
Injection, solutionIntravenous18 MG/2ML
Injection, solutionIntravenous180 MG/20ML
Injection, solutionIntravenous45 MG/5ML
Injection, solutionIntravenous90 MG/10ML
Injection, solutionIrrigation0.9 %
Solution, concentrateParenteral0.117 g/ml
Injection, solutionParenteral0.9 %
Injection, solutionParenteral3 %
Injection, solutionParenteral5 %
Injection, solution, concentrateIntravenous2 mEq/mL
Injection, solution, concentrateIntravenous3 mEq/mL
Injection, solution0.9 %
Injection, solution3 %
Injection, solution5 %
Injection, solution, concentrateIntravenous0.175 g
Injection, solution, concentrateIntravenous1.17 g
Injection, solution, concentrateIntravenous1.75 g
SolutionIrrigation; Parenteral0.9 %
SolutionParenteral0.9 %
Injection, solutionIntravenous3 %
Injection, solution, concentrateIntravenous3 %
Injection, solution, concentrateIntravenous5 %
Solution, concentrateIntravenous0.117 g/ml
Solution, concentrateIntravenous0.175 g/ml
Solution, concentrateParenteral0.175 g/ml
PowderHemodialysis
InhalantRespiratory (inhalation)0.9 mg/100mL
InjectionIntramuscular; Intravenous; Subcutaneous0.9 mg/10mL
InjectionIntramuscular; Intravenous; Subcutaneous234 mg/1mL
InjectionIntramuscular; Intravenous; Subcutaneous9 mg/1mL
InjectionIntravascular.9 mg/1mL
InjectionIntravenous0.45 g/50mL
InjectionIntravenous0.9 g/100mL
InjectionIntravenous450 mg/50mL
InjectionIntravenous450 mg/100mL
InjectionIntravenous9 mg/1mL
InjectionIntravenous900 mg/1000mL
InjectionIntravenous900 mg/100mL
Injection, solutionIntramuscular; Intravenous; Subcutaneous234 mg/1mL
Injection, solutionIntramuscular; Intravenous; Subcutaneous9 mg/1mL
Injection, solutionIntravenous0.45 g/100mL
Injection, solutionIntravenous0.9 g/100mL
Injection, solutionIntravenous146 mg/1mL
Injection, solutionIntravenous234 mg/1mL
Injection, solutionIntravenous3 g/100mL
Injection, solutionIntravenous4.5 g/1000mL
Injection, solutionIntravenous450 mg/50mL
Injection, solutionIntravenous450 mg/100mL
Injection, solutionIntravenous5 g/100mL
Injection, solutionIntravenous9 g/1000mL
Injection, solutionIntravenous9 g/1mL
Injection, solutionIntravenous9 mg/1mL
Injection, solutionIntravenous9 g/1
Injection, solutionIntravenous900 mg/100mL
Injection, solution, concentrateIntravenous2.92 g/20mL
Injection, solution, concentrateIntravenous20 g/100mL
Injection, solution, concentrateIntravenous234 mg/1mL
Injection, solution, concentrateIntravenous5.84 g/40mL
IrrigantIrrigation0.9 g/100mL
IrrigantIrrigation450 mg/100mL
IrrigantIrrigation9 g/1000mL
IrrigantIrrigation900 mg/100mL
OintmentOphthalmic50 mg/1g
Powder, for solutionOral1 g
SolutionIntravenous0.45 g/100mL
SolutionIntravenous0.9 g/100mL
SolutionRespiratory (inhalation)0.027 mg/3mL
Solution / dropsAuricular (otic); Ophthalmic3 g/100mL
Solution / dropsOphthalmic50 mg/1mL
Syrup20 g/100mL
Tablet300 mg
LiquidIntravenous
LiquidIntravenous; Subcutaneous
Solution
Injection, solution20 g/100mL
LiquidIntramuscular; Intravenous; Subcutaneous
Capsule800 mg
Solution / dropsOphthalmic3 g/100mL
SolutionIrrigation0.9 g/100mL
InhalantRespiratory (inhalation)9 g/1L
LiquidParenteral
SolutionIntramuscular; Intraperitoneal; Intravenous; Subcutaneous
SolutionIntravenous; Subcutaneous
LiquidIrrigation; Topical
SolutionIrrigation900 mg/100mL
SolutionIntraperitoneal; Irrigation
SolutionIntraperitoneal; Irrigation; Topical
TabletOral500 mg/1
PowderOral1 g
PowderOral5 g
Injection, solution, concentrateIntravenous3 g/100mL
TabletIrrigation
TabletOral
Solution / dropsOphthalmic900 mg/100mL
SolutionTopical900 mg/100mL
Injection, solution, concentrateIntravenous; Subcutaneous234 mg/1mL
SolutionIntravenous0.2 mg
SolutionIntraperitoneal25.7 mg
SolutionIntravenous6 mg
SolutionIntravenous33 mg
SolutionIntravenous0.225 g
SolutionIntravenous0.9 g
SolutionConjunctival; Ophthalmic12.5 mg
SolutionRespiratory (inhalation)
MouthwashOral4 mcg/100mL
MouthwashOral90 mg/100mL
MouthwashOral4.4 mg/100mL
KitIntravenous
SolutionIntraocular; Irrigation0.39 g
Liquid; powder, for solutionIntravenous
SolutionIntrasinal; Nasal900 mg
SolutionParenteral0.9 g
LiquidOral
TabletOral
LiquidIrrigation
Powder, for solutionOral1.43 g
SolutionIntravenous594 mg
SolutionIrrigation0.9 %
Injection, solutionIntravenous3 g
SolutionIntravenous; Irrigation0.62 g/100ml
SolutionRectal15 g/100mL
SolutionIntraocular; Intravenous1 mL
SolutionTopical30 g/100mL
SolutionIntravenous6 g/100mL
Injection, solutionIntravenous30 g/500mL
SprayNasal3 g/100g
KitNasal
LiquidTopical6.5 mg/1mL
SprayNasal.65 g/100mL
KitIntramuscular; Intravenous
Granule, for solutionNasal
Capsule780 mg
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US5945449No1999-08-312017-10-31US flag
US7300674No2007-11-272023-03-04US flag
US6077836No2000-06-202017-06-20US flag
US6248726No2001-06-192018-06-19US flag
US7291324No2007-11-062022-10-22US flag
US7169381No2007-01-302024-09-01US flag
US7658914No2010-02-092024-09-01US flag
US7084130No2006-08-012021-11-29US flag
US9326969No2016-05-032033-09-10US flag
US9592252No2017-03-142032-08-11US flag
US9707297No2017-07-182033-09-10US flag
US8999313No2015-04-072033-09-10US flag
US10016504No2018-07-102033-09-10US flag
US10646512No2012-03-252032-03-25US flag
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility108.0 mg/mLALOGPS
logP0.06ALOGPS
logP-0.77ChemAxon
logS0.26ALOGPS
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on October 01, 2015 13:54 / Updated on October 26, 2020 22:41

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