Sodium chloride

Identification

Summary

Sodium chloride is an ingredient found in a variety of nutritional products as a source of electrolytes and water.

Brand Names

Amphenol-40, As 3, Bi-peglyte, Bicart, Bss, Bss Ophthalmic Solution, Cardioplegic, Citrasate, Clinimix E 2.75/5, Colyte, Corvatrol, Dextrose and Electrolyte No. 75, Dianeal, Dianeal Low Calcium 1.5, Dianeal Pd-2/1.5, Entocort, Extraneal, Eye Stream, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hemosate Ultra, Hespan, Hizentra, Hyperlyte, Intersol, Isolyte S, Isolyte S pH 7.4, Isoplate, Lactate 1-2-3, Lactated Ringers, Menopur, Moviprep, Muro 128, Naturalyte, Normosol-M, Normosol-R, Nulytely, Nxstage Pureflow, P-Care M, P-Care MG, P-care, P-care X, Peglyte, Phoxillum, Physiolyte, Physioneal 40, Physiosol, Plasma-lyte, Plasma-lyte 148, Plasma-lyte 148 In 5 % Dextrose, Plasma-lyte R, Plasmalyte A, Plegisol, Plenvu, Prismasol, Procalamine 3, Ringers, Sag-M, Sclerodex, Tis-U-sol

Generic Name

Sodium chloride

DrugBank Accession Number

DB09153

Background

Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the primary salt in seawater and in the extracellular fluid of many multicellular organisms. It is listed on the World Health Organization Model List of Essential Medicines.

Type

Small Molecule

Groups

Approved, Vet approved

Structure

Similar Structures

Weight: Average: 58.443
Monoisotopic: 57.958622382
Chemical Formula: ClNa

Synonyms

Cloruro sódico
Natriumchlorid
Natrum muriaticum
Sodium chloride

External IDs

B1655
LS-1700
NSC-77364

Pharmacology

Indication

This intravenous solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration. Also, designed for use as a diluent and delivery system for intermittent intravenous administration of compatible drug additives.

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Associated Conditions

Associated Therapies

Contraindications & Blackbox Warnings

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Pharmacodynamics

Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance, and osmotic pressure of body fluids. Sodium is also associated with chloride and bicarbonate in the regulation of the acid-base equilibrium of body fluid. Chloride, the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in the chloride concentration.

Mechanism of action

Sodium and chloride — major electrolytes of the fluid compartment outside of cells (i.e., extracellular) — work together to control extracellular volume and blood pressure. Disturbances in sodium concentrations in the extracellular fluid are associated with disorders of water balance.

Absorption

Absorption of sodium in the small intestine plays an important role in the absorption of chloride, amino acids, glucose, and water. Chloride, in the form of hydrochloric acid (HCl), is also an important component of gastric juice, which aids the digestion and absorption of many nutrients.

Volume of distribution

The volume of distribution is 0.64 L/kg.

Protein binding

Sodium is not bound by plasma proteins.

Metabolism

The salt that is taken in to gastro intestinal tract remains for the most part unabsorbed as the liquid contents pass through the stomach and small bowel. On reaching the colon this salt, together with the water is taken in to the blood. As excesses are absorbed the kidney is constantly excreting sodium chloride, so that the chloride level in the blood and tissues remains fairly constant.Further more, if the chloride intake ceases, the kidney ceases to excrete chlorides. Body maintains an equilibrium retaining the 300gm of salt dissolved in the blood and fluid elements of the tissue dissociated into sodium ions and chloride ions.

Route of elimination

Substantially excreted by the kidneys.

Half-life

17 minutes

Clearance

Not Available

Adverse Effects

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Toxicity

The rare inadvertent intravascular administration or rapid intravascular absorption of hypertonic sodium chloride can cause a shift of tissue fluids into the vascular bed, resulting in hypervolemia, electrolyte disturbances, circulatory failure, pulmonary embolism, or augmented hypertension.

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Lithium carbonate	Sodium chloride may increase the excretion rate of Lithium carbonate which could result in a lower serum level and potentially a reduction in efficacy.
Lithium citrate	Sodium chloride may increase the excretion rate of Lithium citrate which could result in a lower serum level and potentially a reduction in efficacy.
Lithium hydroxide	Sodium chloride may increase the excretion rate of Lithium hydroxide which could result in a lower serum level and potentially a reduction in efficacy.
Tolvaptan	The risk or severity of adverse effects can be increased when Sodium chloride is combined with Tolvaptan.

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Food Interactions

No interactions found.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Sodium cation	ionic	LYR4M0NH37	17341-25-2	FKNQFGJONOIPTF-UHFFFAOYSA-N
Chloride ion	ionic	Q32ZN48698	16887-00-6	VEXZGXHMUGYJMC-UHFFFAOYSA-M

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
0.45% Sodium Chloride Injection USP	Solution	4.5 mg / mL	Intravenous	B. Braun Medical Inc.	1993-12-31	Not applicable
0.9% Sodium Chloride	Irrigant	900 mg/100mL	Irrigation	HF Acquisition Co LLC, DBA HealthFirst	2018-10-18	Not applicable
0.9% Sodium Chloride	Injection, solution	900 mg/100mL	Intravenous	HF Acquisition Co LLC, DBA HealthFirst	2018-10-18	Not applicable
0.9% Sodium Chloride	Injection, solution	900 mg/100mL	Intravenous	Sc Infomed Fluids Srl	2017-04-24	2017-04-24
0.9% Sodium Chloride	Injection, solution	900 mg/100mL	Intravenous	HF Acquisition Co LLC, DBA HealthFirst	2018-10-16	Not applicable
0.9% Sodium Chloride	Injection, solution	9 mg/1mL	Intramuscular; Intravenous; Subcutaneous	HF Acquisition Co LLC, DBA HealthFirst	2019-07-18	Not applicable
0.9% Sodium Chloride	Injection, solution	900 mg/100mL	Intravenous	HF Acquisition Co LLC, DBA HealthFirst	2020-04-07	Not applicable
0.9% Sodium Chloride	Injection, solution	900 mg/100mL	Intravenous	HF Acquisition Co LLC, DBA HealthFirst	2020-05-21	Not applicable
0.9% Sodium Chloride	Injection, solution	900 mg/100mL	Intravenous	HF Acquisition Co LLC, DBA HealthFirst	2020-04-07	Not applicable
0.9% Sodium Chloride Injection	Solution	900 mg / 100 mL	Intravenous	Fresenius Kabi	2013-12-10	Not applicable

Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
0.9% Sodium Chloride	Injection, solution	9 mg/1mL	Intravenous	HF Acquisition Co LLC, DBA HealthFirst	2021-07-17	Not applicable
3% Sodium Chloride	Injection, solution	3 g/100mL	Intravenous	Becton Dickinson and Company	2020-02-28	Not applicable
Amphenol-40	Injection, solution	9 mg/1mL	Intramuscular; Intravenous; Subcutaneous	It3 Medical Llc	2017-03-01	Not applicable
Bacteriostatic Sodium Chloride	Injection	9 mg/1mL	Intramuscular; Intravenous; Subcutaneous	Cardinal Health	2000-08-08	2016-03-31
Bacteriostatic Sodium Chloride	Injection	9 mg/1mL	Intramuscular; Intravenous; Subcutaneous	Fresenius Kabi USA, LLC	2000-08-08	Not applicable
Corvatrol 0.9%	Injection	9 mg/1mL	Intramuscular; Intravenous; Subcutaneous	It3 Medical Llc	2017-03-01	Not applicable
HAEMONETICS 0.9 % Sodium Chloride	Solution	900 mg/100mL	Extracorporeal	Haemonetics Corporation	2013-01-07	Not applicable
Sodium Chloride	Injection, solution	9 g/1000mL	Intravenous	Mylan Institutional	2017-05-25	2017-05-26
Sodium Chloride	Injection	9 mg/1mL	Intravenous	REMEDYREPACK INC.	2018-09-18	2020-05-21
Sodium Chloride	Injection	900 mg/100mL	Intravenous	Fresenius Medical Care North America	2007-04-12	Not applicable

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
0.9% SODIUM CHLORIDE (500ML ROUND PLASTIC CONTAINER)	Solution	0.9 %		POLYLAB BIOTECH SDN. BHD.	2016-03-03	2019-05-10
0.9% SODIUM CHLORIDE PARENTERAL SOLUTION (1000ML PLASTIC)	Solution	0.9 %	Parenteral	POLYLAB BIOTECH SDN. BHD.	2017-07-04	2019-05-10
Altachlore Sodium Chloride Hypertonicity	Solution / drops	50 mg/1mL	Ophthalmic	Altaire Pharmaceuticals Inc.	2002-09-24	Not applicable
Ancient Secrets Breathe Again	Aerosol, spray	20 mg/100mL	Nasal	Lotus Brands, Inc.	2011-08-15	Not applicable
Ancient Secrets Breathe Again Childrens	Aerosol, spray	20 mg/100mL	Nasal	Lotus Brands, Inc.	2011-08-15	2015-06-01
Aqua Maris Baby	Liquid	11.25 mg/1mL	Nasal	Jgl North America Llc	2010-07-08	Not applicable
Aqua Maris Baby	Liquid	9 mg/1mL	Nasal	JGL d. d.	2022-05-04	Not applicable
Aqua Maris Classic	Spray	10.5 mg/1mL	Nasal	JGL d. d.	2022-05-06	Not applicable
Aqua Maris Clean	Spray	9 mg/1mL	Nasal	JGL d. d.	2022-05-05	Not applicable
Aqua Maris Clean	Spray	9 mg/1mL	Nasal	JGL d. d.	2022-05-05	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
(20 Mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP	Sodium chloride (300 mg / 100 mL) + Dextrose, unspecified form (3.3 g / 100 mL) + Potassium chloride (150 mg / 100 mL)	Solution	Intravenous	Baxter Laboratories	1978-12-31	Not applicable
(20 Mmol/l) Potassium Chloride In 5% Dextrose and 0.9% Sodium Chloride Injection USP	Sodium chloride (900 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Potassium chloride (150 mg / 100 mL)	Solution	Intravenous	Baxter Laboratories	1990-12-31	Not applicable
(20mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP	Sodium chloride (900 mg / 100 mL) + Potassium chloride (150 mg / 100 mL)	Solution	Intravenous	Baxter Laboratories	1989-12-31	Not applicable
(20mmol/l) Potassium Chloride In 5% Dextrose and 0.2% Sodium Chloride Injection USP	Sodium chloride (200 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Potassium chloride (150 mg / 100 mL)	Solution	Intravenous	Baxter Laboratories	1989-12-31	2016-07-15
(20mmol/l) Potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USP	Sodium chloride (450 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Potassium chloride (150 mg / 100 mL)	Solution	Intravenous	Baxter Laboratories	1989-12-31	Not applicable
(40 Mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP	Sodium chloride (900 mg / 100 mL) + Potassium chloride (300 mg / 100 mL)	Liquid	Intravenous	Baxter Laboratories	1989-12-31	Not applicable
(40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USP	Sodium chloride (600 mg / 100 mL) + Calcium chloride (20 mg / 100 mL) + Sodium lactate (310 mg / 100 mL) + Potassium chloride (328 mg / 100 mL)	Solution	Intravenous	Baxter Laboratories	2002-12-11	2016-07-15
(40mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP	Sodium chloride (300 mg / 100 mL) + Dextrose, unspecified form (3.3 g / 100 mL) + Potassium chloride (300 mg / 100 mL)	Solution	Intravenous	Baxter Laboratories	1978-12-31	Not applicable
(40mmol/l)potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USP	Sodium chloride (450 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Potassium chloride (300 mg / 100 mL)	Solution	Intravenous	Baxter Laboratories	1989-12-31	Not applicable
%5 DEKSTROZ %0,2 SODYUM KLORUR COZELTISI SETLI, 100 ML	Sodium chloride (5 %) + D-glucose monohydrate (0.2 %)	Solution	Intravenous	KOÇAK FARMA İLAÇ VE KİMYA SAN. A.Ş.	2020-08-14	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
%0,9 IZOTONIK 1000 ML SOLUSYON(SETLI)	Sodium chloride (0.9 %)	Solution	Intravenous	POLİFARMA İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
%0,9 IZOTONIK 500 ML SOLUSYON(SETLI)	Sodium chloride (0.9 %)	Solution	Intravenous	POLİFARMA İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
%0,9 IZOTONIK 500 ML SOLUSYON(SETSIZ)	Sodium chloride (0.9 %)	Solution	Intravenous	POLİFARMA İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
%0,9 IZOTONIK SODYUM KLORUR 250 ML SOLUSYON(SETLI)	Sodium chloride (0.9 %)	Solution	Intravenous	POLİFARMA İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
%0,9 IZOTONIK SODYUM KLORUR 250 ML SOLUSYON(SETSIZ)	Sodium chloride (0.9 %)	Solution	Intravenous	POLİFARMA İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
%0,9 IZOTONIK SODYUM KLORUR ICEREN IRRIGASYON SOLUSYONU 1000 ML (POLIPROPILEN SISE)	Sodium chloride (0.9 %)	Solution		OSEL İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
%0,9 IZOTONIK SODYUM KLORUR ICEREN IRRIGASYON SOLUSYONU 500 ML (POLIPROPILEN SISE)	Sodium chloride (0.9 %)	Solution		OSEL İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
%0,9 SODYUM KLORUR 10 ML 10 AMPUL	Sodium chloride (0.9 %)	Solution	Intravenous	OSEL İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
%0,9 SODYUM KLORUR 250 ML SOLUSYON SETSIZ	Sodium chloride (0.9 %)	Solution	Intravenous	OSEL İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
%09 IZOTONIK 1000 ML SOLUSYON	Sodium chloride (9 %)	Solution	Intravenous	POLİFARMA İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable

Chemical Identifiers

UNII: 451W47IQ8X
CAS number: 7647-14-5
InChI Key: FAPWRFPIFSIZLT-UHFFFAOYSA-M
InChI: InChI=1S/ClH.Na/h1H;/q;+1/p-1
IUPAC Name: sodium chloride
SMILES: [Na+].[Cl-]

References

General References

ChemIDplus [Link]
Pubchem [Link]

External Links

KEGG Drug: D02056
KEGG Compound: C13563
PubChem Compound: 5234
PubChem Substance: 310265066
ChemSpider: 5044
BindingDB: 50098543
RxNav: 9863
ChEBI: 26710
ChEMBL: CHEMBL1200574
PharmGKB: PA451382
Wikipedia: Sodium_chloride

MSDS

Download (89.8 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Active Not Recruiting	Treatment	Allergic Rhinitis (AR) / Allergy to Tree Pollen / Seasonal Allergic Rhinitis	1
4	Active Not Recruiting	Treatment	Blood Loss During Surgery	1
4	Active Not Recruiting	Treatment	Burns / Surgery / Tranexamic Acid / Wounds and Injuries	1
4	Active Not Recruiting	Treatment	Caudal epidural block therapy / Postoperative pain	1
4	Active Not Recruiting	Treatment	Children, Only / Pain / Remifentanil / Tonsillectomy	1
4	Active Not Recruiting	Treatment	Endothelial Dysfunction / Iron Toxicity / Renal Anemia / Stress Oxidative	1
4	Completed	Not Available	Brain Swelling	1
4	Completed	Not Available	Colonoscopy	1
4	Completed	Not Available	Corneal Staining	1
4	Completed	Not Available	Dry Eyes	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Solution	Intravenous	0.9 %
Solution	Intravenous	20 %
Solution	Intravenous	3 %
Solution	Intravenous	4.5 mg / mL
Solution	Intramuscular; Intravenous; Subcutaneous	9 mg / mL
Solution	Intravenous	900 mg / 100 mL
Solution	Irrigation	0.9 %
Solution	Irrigation	900 mg / 100 mL
Solution	Irrigation	1.6 g / 100 mL
Injection	Intravenous	50 g/L
Solution	Irrigation	12 g / 100 mL
Solution	Intravenous	20 % w/v
Solution	Intravenous	23.4 %
Liquid	Intravenous	30 mg / mL
Kit	Irrigation; Ophthalmic; Respiratory (inhalation); Topical
Kit	Irrigation; Ophthalmic; Topical
Kit	Irrigation; Oral; Respiratory (inhalation); Topical
Kit	Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical
Solution	Intravenous	5 g / 100 mL
Solution	Hemodialysis	0.257 g/1000ml
Solution	Respiratory (inhalation)	0.45 %
Solution	Respiratory (inhalation)	0.9 %
Solution	Respiratory (inhalation)	450 mg / 100 mL
Solution	Respiratory (inhalation)	900 mg / 100 mL
Solution	Parenteral	9 mg
Kit	Intradermal; Subcutaneous
Solution	Topical	9 mg/ml
Solution; spray	Nasal	9 mg/ml
Solution	Irrigation; Parenteral
Powder, for solution	Intraocular
Solution	Intraocular
Aerosol, spray	Nasal	20 mg/100mL
Liquid	Topical
Liquid	Nasal	11.25 mg/1mL
Liquid	Nasal	9 mg/1mL
Spray	Nasal	10.5 mg/1mL
Spray	Nasal	9 mg/1mL
Spray	Auricular (otic)	11.25 mg/1mL
Spray	Oral	37.5 mg/1mL
Spray	Nasal	0.9 mg/100mL
Spray	Nasal	0.9 g/100mL
Inhalant	Respiratory (inhalation)	1.7 mg/1mL
Solution	Intravenous drip
Liquid	Respiratory (inhalation)	0.9 %
Solution	Ophthalmic
Liquid	Dental	0.5 g/100mL
Solution / drops	Nasal
Solution; spray	Nasal
Kit; powder, for solution; tablet, delayed release	Oral
Kit; powder, for solution	Hemodialysis
Powder, for solution	Oral	1.685 g
Liquid; powder, for solution	Subcutaneous
Solution	Hemodialysis; Intravenous
Solution	Hemodialysis; Intravenous	0.187 g/L
Liquid	Oral	0.5 g/100mL
Solution / drops; suspension / drops
Spray	Nasal
Aerosol, metered	Respiratory (inhalation)	.9 %
Kit; solution	Intraocular
Liquid	Ophthalmic
Liquid	Topical	0.495 g/50mL
Liquid	Topical	0.99 g/100mL
Liquid	Topical	2.97 g/300mL
Liquid	Topical	4.95 g/500mL
Powder	Topical	60 g/300g
Solution	Intraperitoneal	0.2573 g/l
Solution	Intraperitoneal	0.1838 g/L
Solution
Solution	Intra-arterial
Enema	Rectal	15 %
Solution	Nasal	.9 %
Solution	Nasal; Ophthalmic	900 mg/100mL
Swab	Topical	0.9 g/100mL
Liquid	Nasal	6.5 mg/1mL
Solution	Intramuscular; Intravenous; Subcutaneous	9 mg
Solution	Intravenous	9 g
Solution	Intravenous; Irrigation	9 mg
Solution, concentrate	Intravenous	11.7 g
Solution	Intravenous	1.17 g
Solution	Intravenous	20 mEq
Solution	Parenteral	20 MBq
Solution	Intravenous	0.009 g
Solution	Intravenous	900 mg
Injection	Intravenous	10 g
Solution	Intravenous	1.1688 g
Solution	Intravenous	116.9 mg
Powder, for solution	Nasogastric
Solution	Intravenous	0.27 g/1000ml
Injection	Intravenous	0.027 g/100ml
Injection	Intravenous	270 mg/l
Injection, powder, lyophilized, for solution	Hemodialysis
Liquid	Ophthalmic	0.9 g/100mL
Liquid	Epidural; Infiltration; Subcutaneous
Ointment	Topical	5 %
Solution	Topical	5 %
Solution	Ophthalmic
Powder	Nasal
Spray	Nasal	0.9 g/100g
Solution	Irrigation
Paste, dentifrice	Oral
Solution	Intraperitoneal
Injection	Intravenous	5.0 % w/v
Liquid	Intravenous
Injection	Intravenous	5 g/100ml
Injection	Intravenous
Solution	Respiratory (inhalation)	.45 %
Solution	Respiratory (inhalation)	10 %
Solution	Respiratory (inhalation)	3 %
Liquid	Topical	.9 %
Solution	Intraperitoneal; Irrigation
Solution	Intraperitoneal	18.3 mg/100ml
Injection, solution	Intraperitoneal
Injection	Subcutaneous	4.5 mg/0.5mL
Liquid	Intradermal; Percutaneous; Subcutaneous
Liquid	Subcutaneous
Solution	Intravenous	1.47 mg/1ml
Kit	Epidural; Infiltration; Intracaudal; Subcutaneous; Topical
Injection, solution, concentrate	Intramuscular
Solution	Ophthalmic	0.02 %
Spray	Topical
Spray	Nasal	0.39 mL/60mL
Solution	Intravenous	4.21 g/1000ml
Kit	Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
Liquid	Ophthalmic	0.48 %
Granule, for solution	Oral
Injection, solution	Intravenous	1000 ML
Solution	Intrathecal
Injection	Intrathecal
Solution	Intravenous; Subcutaneous
Powder	Oral
Solution	Rectal	2.5 g
Enema; kit; tablet	Rectal
Spray	Nasal	30 mg/1mL
Kit	Epidural; Infiltration
Solution	Intraperitoneal	25.7 mg/100ml
Solution	Intraperitoneal	257 mg/l
Solution	Nasal	0.29 mg/44mL
Kit; liquid; powder, for solution	Intramuscular; Subcutaneous
Liquid; powder, for solution	Intramuscular; Subcutaneous
Solution	Irrigation; Topical	0.9 g
Liquid	Topical	1.5 g/100mL
Granule, for solution	Oral	64 g
Solution	Intra-articular; Irrigation	0.009 g
Solution	Parenteral	0.9 g
Solution	Intrasinal; Nasal	0.9 mg
Solution, concentrate	Hemodialysis
Solution	Intravenous	0.15 g/1000ml
Injection	Intravenous	7.01 g/1000ml
Spray	Oral
Aerosol, spray	Oral
Injection	Parenteral
Injection, solution	Parenteral
Powder, for solution	Nasogastric; Oral
Solution	Extracorporeal	9 g
Solution	Hemodialysis
Solution	Hemodialysis	7.77 g/l
Solution	Hemodialysis	6.47 g/l
Solution	Hemodialysis	8.46 g/l
Solution	Extracorporeal	900 mg/100mL
Solution	Extracorporeal
Solution	Hemodialysis	8.8 g/l
Solution	Hemodialysis	66 g/l
Solution	Hemodialysis	8.85 g/l
Solution	Hemodialysis	9.74 g/l
Liquid	Hemodialysis
Solution	Hemodialysis	6.77 g/l
Injection	Intravenous	10 iu/ml
Solution	Oral	0.2892 g
Solution	Ophthalmic	50 mg
Solution	Conjunctival; Ophthalmic
Solution	Nasal
Enema	Rectal	6 g/20ml
Liquid; powder, for solution	Intramuscular
Solution	Respiratory (inhalation)
Spray	Nasal
Liquid	Nasal	.65 g/100mL
Solution	Intravenous	0.9 % w/v
Injection, solution	Intravenous	20 %
Injection	Intravenous
Liquid	Intraperitoneal
Solution	Hemodialysis; Intraperitoneal
Liquid	Intravesical
Liquid	Intraocular
Solution	Intravenous
Solution
Solution	Intravenous
Kit	Intravenous; Topical
Irrigant	Irrigation
Solution	Intravenous	1000 ml
Solution	Intravenous	150 ml
Solution	Intravenous	250 ml
Solution	Intravenous	50 ml
Solution	Intravenous	500 ml
Solution	Intravenous	100 ml
Liquid	Infiltration; Subcutaneous; Topical
Solution	Rectal	150 mg/ml
Tablet	Vaginal
Injection	Intravenous	20 mg/100ml
Solution, for slush	Irrigation
Gel	Vaginal
Injection	Intravenous	0.027 % w/v
Solution / drops	Ophthalmic
Solution	Conjunctival; Ophthalmic	0.09 g
Injection, solution
Liquid	Oral
Powder, for solution	Subcutaneous
Injection	Subcutaneous
Liquid	Buccal
Spray	Buccal
Powder, for solution	Oral	13.125 g
Powder, for solution	Oral	13.125 G
Injection, solution, concentrate	Oral
Kit	Oral
Injection, solution	Hemodialysis; Intravenous
Solution	Hemodialysis	1.1 g/L
Solution	Ophthalmic	20 mg/1mL
Solution	Ophthalmic	50 mg/1mL
Liquid	Intraocular; Ophthalmic	2 %
Solution	Intravenous	117 mg
Lotion	Topical	.65 mL/100mL
Solution	Nasal; Respiratory (inhalation)	9 mg
Spray	Nasal	9.5 mg/1mL
Spray	Nasal	2600 mg/100mL
Solution	Intrasinal; Nasal	900 mg
Solution	Nasal; Respiratory (inhalation)	6.5 mg
Solution	Nasal; Respiratory (inhalation)	9.054 mg
Solution	Intrasinal; Nasal	6.5 mg
Spray	Nasal	3 mL/100mL
Spray	Nasal	1.2 mg/10mL
Solution	Intravenous	9 g/L
Solution	Intravenous	1.169 g
Injection, solution	Parenteral	9 mg/ml
Kit; solution	Intraocular; Irrigation
Solution	Intrasinal; Nasal	0.65 g
Solution	Topical	9 mg
Tablet	Oral	1 g/1
Emulsion	Parenteral
Emulsion	Intravenous
Injection, emulsion	Intravenous	4.656 g/1000ml
Injection, emulsion	Intravenous	6.792 g/1000ml
Injection, solution, concentrate	Intravenous
Solution	Intraperitoneal	0.184 g/l
Injection, emulsion	Intravenous
Ointment	Ophthalmic	50 mg/g
Solution, concentrate	Oral
Solution	Intraocular; Ophthalmic
Solution	Intraocular; Irrigation
Liquid; mouthwash	Oral
Solution	Extracorporeal; Intrabiliary; Intracardiac
Solution	Auricular (otic)
Solution	Oral
Powder	Oral	238.33 g
Liquid	Intradermal; Subcutaneous
Injection, solution
Solution	Conjunctival; Ophthalmic	90000 mg
Solution		0.9 %
Solution	Intraperitoneal	0.507 g/l
Irrigant	Irrigation
Injection, solution	Intravenous
Injection	Intravenous	30 mg/100ml
Injection, solution	Intra-arterial
Powder, for solution	Oral
Solution	Intravenous	50 g/1000ml
Solution	Intravenous	1.5 g/1000ml
Solution	Intravenous	3.00 g/1000ml
Solution	Hemodialysis; Intravenous	0.27 g/l
Kit	Hemodialysis
Solution	Hemodialysis	0.257 g/l
Enema	Rectal
Enema	Rectal	25 % w/v
Injection	Intravenous	0.21 g/100ml
Douche	Vaginal
Powder, for solution	Intravenous
Patch	Transdermal	0.03 g/1g
Kit; liquid; powder	Intralesional; Subcutaneous
Injection, solution	Extracorporeal
Solution	Intravenous	5.03 g/l
Liquid; powder, for solution	Intravenous; Subcutaneous
Solution	Intravenous	0.1 g/500ml
Solution	Irrigation; Topical
Injection	Intravenous	0.33 g/1L
Injection, solution	Irrigation
Solution	Ophthalmic	0.9 % w/v
Solution	Unknown
Powder, for solution	Intramuscular; Subcutaneous
Solution	Ophthalmic	50.00 mg/ml
Spray	Nasal	6.5 mg/1mL
Spray	Oral	6.5 mg/1mL
Spray	Nasal	2.65 mg/100mL
Liquid	Nasal	.9 %
Gel	Nasal	0.9 g/100mL
Cloth	Topical	0.9 g/100mL
Gel	Nasal
Aerosol	Oral
Injection	Intravenous	0.9 % w/v
Liquid	Topical	5 g/100mL
Liquid	Topical	0.7 %
Powder	Topical
Injection, solution	Intravenous	0.9 %
Injection	Intravenous	0.9 %
Liquid	Epidural
Powder, for solution	Nasal
Gel	Nasal	0.9 mg/100mL
Injection, solution	Intravenous
Injection, solution	Parenteral
Solution	Irrigation
Solution	Intravenous	2.25 g
Solution	Irrigation; Parenteral	0.9 g
Solution	Irrigation	0.9 g
Solution	Intravenous	0.1169 g
Solution	Intravenous	0.9 g
Injection, solution	Intravenous	3 %
Injection, solution	Intravenous	5 %
Injection, solution	Parenteral	0.9 %
Injection, solution, concentrate	Intravenous	2 MEQ/ML
Solution	Parenteral	0.9 %
Solution	Parenteral	9 %
Injection, solution	Parenteral	20 MEQ
Injection, solution	Parenteral	20 MEQ/10ML
Injection, solution	Intravenous	18 MG/2ML
Injection, solution	Intravenous	180 MG/20ML
Injection, solution	Intravenous	45 MG/5ML
Injection, solution	Intravenous	90 MG/10ML
Injection, solution	Irrigation	0.9 %
Solution, concentrate	Parenteral	0.117 g/ml
Injection, solution, concentrate	Intravenous
Injection, solution	Parenteral	5 %
Injection, solution, concentrate	Intravenous	0.175 g
Injection, solution, concentrate	Intravenous	1.17 g
Injection, solution, concentrate	Intravenous	1.75 g
Solution	Irrigation; Parenteral	0.9 %
Injection, solution	Intravenous	0.45 %
Injection, solution	Parenteral	0.45 %
Injection, solution	Parenteral	3 %
Injection, solution, concentrate	Intravenous	3 mEq/ml
Injection, solution, concentrate	Intravenous	3 %
Injection, solution, concentrate	Intravenous	5 %
Solution	Intravenous	5 %
Solution, concentrate	Intravenous	0.117 g/ml
Solution, concentrate	Intravenous	0.175 g/ml
Solution	Parenteral
Solution, concentrate	Parenteral	0.175 g/ml
Solution	Intravenous	3 g
Powder	Hemodialysis
Inhalant	Respiratory (inhalation)	0.9 mg/100mL
Injection
Injection	Intramuscular; Intravenous; Subcutaneous	0.9 mg/10mL
Injection	Intramuscular; Intravenous; Subcutaneous	234 mg/1mL
Injection	Intramuscular; Intravenous; Subcutaneous	9 mg/1mL
Injection	Intravascular	.9 mg/1mL
Injection	Intravenous	0.45 g/50mL
Injection	Intravenous	0.9 g/100mL
Injection	Intravenous	450 mg/100mL
Injection	Intravenous	450 mg/50mL
Injection	Intravenous	9 mg/1mL
Injection	Intravenous	900 mg/1000mL
Injection	Intravenous	900 mg/100mL
Injection, solution	Intramuscular; Intravenous; Subcutaneous	9 mg/1mL
Injection, solution	Intravenous	0.45 g/100mL
Injection, solution	Intravenous	0.9 g/100mL
Injection, solution	Intravenous	1125 mg/250mL
Injection, solution	Intravenous	146 mg/1mL
Injection, solution	Intravenous	225 mg/50mL
Injection, solution	Intravenous	2250 mg/500mL
Injection, solution	Intravenous	234 mg/1mL
Injection, solution	Intravenous	3 g/100mL
Injection, solution	Intravenous	4.5 g/1000mL
Injection, solution	Intravenous	450 mg/50mL
Injection, solution	Intravenous	450 mg/100mL
Injection, solution	Intravenous	5 g/100mL
Injection, solution	Intravenous	9 g/1000mL
Injection, solution	Intravenous	9 mg/1mL
Injection, solution	Intravenous	9 g/1
Injection, solution	Intravenous	900 mg/100mL
Injection, solution, concentrate	Intravenous	2.5 meq/1mL
Injection, solution, concentrate	Intravenous	2.92 g/20mL
Injection, solution, concentrate	Intravenous	234 mg/1mL
Injection, solution, concentrate	Intravenous	4 meq/1mL
Injection, solution, concentrate	Intravenous	5.84 g/40mL
Irrigant	Irrigation	0.9 g/100mL
Irrigant	Irrigation	450 mg/100mL
Irrigant	Irrigation	9 g/1000mL
Irrigant	Irrigation	900 mg/100mL
Ointment	Ophthalmic	50 mg/1g
Solution	Intravenous	0.45 g/100mL
Solution	Intravenous	0.9 g/100mL
Solution	Respiratory (inhalation)	0.027 mg/3mL
Solution / drops	Ophthalmic	50 mg/1mL
Solution, concentrate	Oral	936 mg/4mL
Injection	Intravenous	2.75 g/100ml
Liquid	Intravenous	450 mg / 100 mL
Injection	Intravenous	5.5 g/100ml
Solution	Ophthalmic	0.9 g/100mL
Liquid	Intravenous; Subcutaneous	9 mg / mL
Solution	Intravenous	3 g / 100 mL
Liquid	Intravenous	23.4 g / 100 mL
Liquid	Intramuscular; Intravenous; Subcutaneous	9 mg / mL
Injection	Intravenous	20 g/100ml
Solution	Irrigation	0.9 g/100mL
Inhalant	Respiratory (inhalation)	9 g/1L
Liquid	Intravenous	9 mg / mL
Liquid	Intramuscular; Intravenous; Subcutaneous	.9 %
Liquid	Intravenous	234 mg / mL
Solution	Intravenous	234 mg / mL
Liquid	Intravenous	.9 %
Solution	Intravenous	9 mg / mL
Solution	Intravenous	50 mg / mL
Injection	Intravenous; Subcutaneous	0.9 g/100ml
Injection	Intravenous; Subcutaneous	0.9 % w/v
Liquid	Parenteral	9 mg / mL
Solution	Intramuscular; Intraperitoneal; Intravenous; Subcutaneous	9 mg / mL
Solution	Intramuscular; Intravenous; Subcutaneous	234 mg / mL
Solution	Intravenous	146 mg / mL
Injection	Intravenous	0.45 %
Solution	Intramuscular; Intravenous; Subcutaneous	0.45 %
Solution	Intramuscular; Intravenous; Subcutaneous	0.9 %
Solution	Intravenous; Subcutaneous	9 mg / mL
Injection	Intravenous	0.45 g/100ml
Solution	Intravenous	9 g/1000ml
Injection	Intravenous	3 g/100ml
Liquid	Irrigation; Topical	9 mg / mL
Solution	Intraperitoneal; Irrigation	9 mg / mL
Solution	Intraperitoneal; Irrigation; Topical	9 mg / mL
Tablet	Oral	500 mg/1
Tablet	Irrigation	1 g / tab
Tablet	Oral	600 mg
Injection, solution, concentrate	Intravenous; Subcutaneous	234 mg/1mL
Solution	Parenteral	2 g
Powder, for solution	Oral	2.9 g
Solution	Parenteral	0.117 g
Solution	Intravenous	9 mg
Solution	Intravenous	0.225 g
Solution	Respiratory (inhalation)
Kit	Intravenous
Solution	Parenteral
Solution	Intravenous	0.3675 g/1000ml
Liquid; powder, for solution	Intravenous
Solution	Intrasinal; Nasal	0.9 g
Solution	Intrasinal; Oral	0.9 g
Solution	Nasal; Respiratory (inhalation)	0.009 g
Solution	Nasal; Respiratory (inhalation)	0.9 g
Suspension	Nasal; Respiratory (inhalation)	0.9 g
Solution	Respiratory (inhalation)	9 mg
Solution	Intrasinal; Nasal	9 mg
Powder, for solution	Hemodialysis
Powder, for solution	Oral	50 g
Tablet	Oral
Liquid	Irrigation
Solution	Conjunctival; Ophthalmic	50 mg
Solution	Intravenous; Irrigation
Solution	Intraocular; Intravenous
Solution	Intravenous	0.3 g
Injection	Intravenous	60 g/l
Spray	Nasal	3 g/100g
Kit	Nasal
Enema	Rectal
Liquid	Topical	6.5 mg/1mL
Spray	Nasal	.65 g/100mL
Kit	Intramuscular; Intravenous
Granule, for solution	Nasal
Solution; spray	Nasal
Lotion	Ophthalmic	0.9 g/100mL
Enema
Tablet		300 mg
Tablet		600 mg

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US5945449	No	1999-08-31	2017-10-31
US7300674	No	2007-11-27	2023-03-04
US6077836	No	2000-06-20	2017-06-20
US6248726	No	2001-06-19	2018-06-19
US7291324	No	2007-11-06	2022-10-22
US7169381	No	2007-01-30	2024-09-01
US7658914	No	2010-02-09	2024-09-01
US7084130	No	2006-08-01	2021-11-29
US9326969	No	2016-05-03	2033-09-10
US9592252	No	2017-03-14	2032-08-11
US9707297	No	2017-07-18	2033-09-10
US8999313	No	2015-04-07	2033-09-10
US10016504	No	2018-07-10	2033-09-10
US10646512	No	2020-05-12	2032-03-25
US10792306	No	2020-10-06	2032-03-09
US10780112	No	2020-09-22	2032-03-09
US10918723	No	2021-02-16	2033-09-10

Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	108.0 mg/mL	ALOGPS
logP	0.06	ALOGPS
logP	-0.77	ChemAxon
logS	0.26	ALOGPS
pKa (Strongest Acidic)	3.09	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m³·mol^-1	ChemAxon
Polarizability	1.78 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available

Drug created at October 01, 2015 19:54 / Updated at July 01, 2022 12:31

Sodium chloride

Identification

Structure for Sodium chloride (DB09153)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra