RNA-directed RNA polymerase L

BE0009862ProteinZaire ebolavirus (strain Mayinga-76)L

RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. It is acted on by 4 drugs in DrugBank.

Gene name
L
UniProtKB entry
Q05318Swiss-Prot
Cellular location
Virion
Residues / weight
2,212 residues · 252,722 Da
Also known as
Large structural protein · Protein L · Replicase · Transcriptase

Resolves to

Protein
UniProtQ05318UniProt nameL_EBOZM
Gene
NCBI Gene911824
Pharmacology
KEGGvg:911824
Drugs

What you can answer from here — as of March 02, 2020

4DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on RNA-directed RNA polymerase L, how selective are they, and which programs against it are still in active trials?

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