Galidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. In animal studies, galidesivir was effective in increasing the survival rates from infections caused by various... In vitro, it displayed broad-spectrum antiviral activity against various negative- and positive-sense RNA viruses, including coronaviruses, filoviruses, and arenaviruses.
- Mechanism
- Curator reviewed · 2 references
Galidesivir works by binding to viral RNA polymerase where the natural nucleotide would bind, leading to the structural change in the viral enzyme due to altered electrostatic interactions. Disruption of viral RNA polymerase activity results in premature termination of the elongating RNA strand.
- Formula / weight
- C11H15N5O3 · 265.2685 g/mol (avg)
- Also known as
- Immucillin A · Immucillin-A
- Code names
- BCX-4430
Resolves to
AMFDITJFBUXZQN-KUBHLMPHSA-NSMILES[H][C@]1(N[C@H](CO)[C@@H](O)[C@H]1O)C1=CNC2=C1N=CN=C2NWhat you can answer from here — as of June 15, 2026
Which drugs share a target with Galidesivir, and which of those have an active Phase 3 trial?
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