Calcium/manganese antiporter SLC30A10

BE0009899ProteinHumansSLC30A10

Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). It is acted on by 3 drugs in DrugBank.

Gene name
SLC30A10
UniProtKB entry
Q6XR72Swiss-Prot
Cellular location
Cell membrane
Residues / weight
485 residues · 52,683 Da
Also known as
Solute carrier family 30 member 10 · Zinc transporter 10 · ZnT-10 · ZNT10 · ZNT8

Resolves to

Protein
UniProtQ6XR72UniProt nameZNT10_HUMAN
Gene
HGNCHGNC:25355NCBI Gene55532GeneCardsSLC30A10
Pharmacology
KEGGhsa:55532
Structure
PDB9KVXPDB9KVYPDB9KVZ
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcium/manganese antiporter SLC30A10, how selective are they, and which programs against it are still in active trials?

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