Caspase-9

BE0009991ProteinHumansCASP9

Involved in the activation cascade of caspases responsible for apoptosis execution. It is acted on by 5 drugs in DrugBank.

Gene name
CASP9
UniProtKB entry
P55211Swiss-Prot
Residues / weight
416 residues · 46,280 Da
Also known as
3.4.22.62 · APAF-3 · Apoptotic protease Mch-6 · Apoptotic protease-activating factor 3 · CASP-9

Resolves to

Protein
UniProtP55211UniProt nameCASP9_HUMAN
Gene
HGNCHGNC:1511NCBI Gene842GeneCardsCASP9
Pharmacology
IUPHAR/GtoPdb1625KEGGhsa:842
Structure
PDB1JXQPDB1NW9PDB2AR9
Drugs

What you can answer from here — as of May 21, 2020

5DrugsApproved to experimental, with action, bond type and pharmacological action
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7Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Caspase-9, how selective are they, and which programs against it are still in active trials?

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