Caspase-9
Details
- Name
- Caspase-9
- Kind
- protein
- Synonyms
- 3.4.22.62
- APAF-3
- Apoptotic protease Mch-6
- Apoptotic protease-activating factor 3
- CASP-9
- ICE-LAP6
- ICE-like apoptotic protease 6
- MCH6
- Gene Name
- CASP9
- UniProtKB Entry
- P55211Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052487|Caspase-9 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
- Number of residues
- 416
- Molecular Weight
- 46280.325
- Theoretical pI
- Not Available
- GO Classification
- Functionscysteine-type endopeptidase activity / cysteine-type endopeptidase activity involved in apoptotic process / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / enzyme activator activity / identical protein binding / peptidase activity / protein kinase binding / SH3 domain bindingProcessesactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / apoptotic process / cellular response to dexamethasone stimulus / cellular response to UV / glial cell apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / kidney development / leukocyte apoptotic process / platelet formation / positive regulation of apoptotic process / positive regulation of neuron apoptotic process / response to cobalt ion / response to estradiol / response to ischemia / response to lipopolysaccharide / signal transduction in response to DNA damageComponentsapoptosome / cytoplasm / cytosol / mitochondrion / nucleus / protein-containing complex
- General Function
- Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP)
- Specific Function
- cysteine-type endopeptidase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0052488|Caspase-9 (CASP9) ATGGACGAAGCGGATCGGCGGCTCCTGCGGCGGTGCCGGCTGCGGCTGGTGGAAGAGCTG CAGGTGGACCAGCTCTGGGACGCCCTGCTGAGCCGCGAGCTGTTCAGGCCCCATATGATC GAGGACATCCAGCGGGCAGGCTCTGGATCTCGGCGGGATCAGGCCAGGCAGCTGATCATA GATCTGGAGACTCGAGGGAGTCAGGCTCTTCCTTTGTTCATCTCCTGCTTAGAGGACACA GGCCAGGACATGCTGGCTTCGTTTCTGCGAACTAACAGGCAAGCAGCAAAGTTGTCGAAG CCAACCCTAGAAAACCTTACCCCAGTGGTGCTCAGACCAGAGATTCGCAAACCAGAGGTT CTCAGACCGGAAACACCCAGACCAGTGGACATTGGTTCTGGAGGATTTGGTGATGTCGGT GCTCTTGAGAGTTTGAGGGGAAATGCAGATTTGGCTTACATCCTGAGCATGGAGCCCTGT GGCCACTGCCTCATTATCAACAATGTGAACTTCTGCCGTGAGTCCGGGCTCCGCACCCGC ACTGGCTCCAACATCGACTGTGAGAAGTTGCGGCGTCGCTTCTCCTCGCTGCATTTCATG GTGGAGGTGAAGGGCGACCTGACTGCCAAGAAAATGGTGCTGGCTTTGCTGGAGCTGGCG CAGCAGGACCACGGTGCTCTGGACTGCTGCGTGGTGGTCATTCTCTCTCACGGCTGTCAG GCCAGCCACCTGCAGTTCCCAGGGGCTGTCTACGGCACAGATGGATGCCCTGTGTCGGTC GAGAAGATTGTGAACATCTTCAATGGGACCAGCTGCCCCAGCCTGGGAGGGAAGCCCAAG CTCTTTTTCATCCAGGCCTGTGGTGGGGAGCAGAAAGACCATGGGTTTGAGGTGGCCTCC ACTTCCCCTGAAGACGAGTCCCCTGGCAGTAACCCCGAGCCAGATGCCACCCCGTTCCAG GAAGGTTTGAGGACCTTCGACCAGCTGGACGCCATATCTAGTTTGCCCACACCCAGTGAC ATCTTTGTGTCCTACTCTACTTTCCCAGGTTTTGTTTCCTGGAGGGACCCCAAGAGTGGC TCCTGGTACGTTGAGACCCTGGACGACATCTTTGAGCAGTGGGCTCACTCTGAAGACCTG CAGTCCCTCCTGCTTAGGGTCGCTAATGCTGTTTCGGTGAAAGGGATTTATAAACAGATG CCTGGTTGCTTTAATTTCCTCCGGAAAAAACTTTTCTTTAAAACATCATAA
- Chromosome Location
- 1
- Locus
- 1p36.21
- External Identifiers
Resource Link UniProtKB ID P55211 UniProtKB Entry Name CASP9_HUMAN GeneCard ID CASP9 HGNC ID HGNC:1511 PDB ID(s) 1JXQ, 1NW9, 2AR9, 3D9T, 3V3K, 3YGS, 4RHW, 5JUY, 5WVC, 5WVE KEGG ID hsa:842 IUPHAR/Guide To Pharmacology ID 1625 NCBI Gene ID 842 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Pamidronic acid approved unknown target activator Details