Caspase-9

Details

Name
Caspase-9
Kind
protein
Synonyms
  • 3.4.22.62
  • APAF-3
  • Apoptotic protease Mch-6
  • Apoptotic protease-activating factor 3
  • CASP-9
  • ICE-LAP6
  • ICE-like apoptotic protease 6
  • MCH6
Gene Name
CASP9
UniProtKB Entry
P55211Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052487|Caspase-9
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
Number of residues
416
Molecular Weight
46280.325
Theoretical pI
Not Available
GO Classification
Functions
cysteine-type endopeptidase activity / cysteine-type endopeptidase activity involved in apoptotic process / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / enzyme activator activity / identical protein binding / peptidase activity / protein kinase binding / SH3 domain binding
Processes
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / apoptotic process / cellular response to dexamethasone stimulus / cellular response to UV / glial cell apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / kidney development / leukocyte apoptotic process / platelet formation / positive regulation of apoptotic process / positive regulation of neuron apoptotic process / response to cobalt ion / response to estradiol / response to ischemia / response to lipopolysaccharide / signal transduction in response to DNA damage
Components
apoptosome / cytoplasm / cytosol / mitochondrion / nucleus / protein-containing complex
General Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP)
Specific Function
cysteine-type endopeptidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0052488|Caspase-9 (CASP9)
ATGGACGAAGCGGATCGGCGGCTCCTGCGGCGGTGCCGGCTGCGGCTGGTGGAAGAGCTG
CAGGTGGACCAGCTCTGGGACGCCCTGCTGAGCCGCGAGCTGTTCAGGCCCCATATGATC
GAGGACATCCAGCGGGCAGGCTCTGGATCTCGGCGGGATCAGGCCAGGCAGCTGATCATA
GATCTGGAGACTCGAGGGAGTCAGGCTCTTCCTTTGTTCATCTCCTGCTTAGAGGACACA
GGCCAGGACATGCTGGCTTCGTTTCTGCGAACTAACAGGCAAGCAGCAAAGTTGTCGAAG
CCAACCCTAGAAAACCTTACCCCAGTGGTGCTCAGACCAGAGATTCGCAAACCAGAGGTT
CTCAGACCGGAAACACCCAGACCAGTGGACATTGGTTCTGGAGGATTTGGTGATGTCGGT
GCTCTTGAGAGTTTGAGGGGAAATGCAGATTTGGCTTACATCCTGAGCATGGAGCCCTGT
GGCCACTGCCTCATTATCAACAATGTGAACTTCTGCCGTGAGTCCGGGCTCCGCACCCGC
ACTGGCTCCAACATCGACTGTGAGAAGTTGCGGCGTCGCTTCTCCTCGCTGCATTTCATG
GTGGAGGTGAAGGGCGACCTGACTGCCAAGAAAATGGTGCTGGCTTTGCTGGAGCTGGCG
CAGCAGGACCACGGTGCTCTGGACTGCTGCGTGGTGGTCATTCTCTCTCACGGCTGTCAG
GCCAGCCACCTGCAGTTCCCAGGGGCTGTCTACGGCACAGATGGATGCCCTGTGTCGGTC
GAGAAGATTGTGAACATCTTCAATGGGACCAGCTGCCCCAGCCTGGGAGGGAAGCCCAAG
CTCTTTTTCATCCAGGCCTGTGGTGGGGAGCAGAAAGACCATGGGTTTGAGGTGGCCTCC
ACTTCCCCTGAAGACGAGTCCCCTGGCAGTAACCCCGAGCCAGATGCCACCCCGTTCCAG
GAAGGTTTGAGGACCTTCGACCAGCTGGACGCCATATCTAGTTTGCCCACACCCAGTGAC
ATCTTTGTGTCCTACTCTACTTTCCCAGGTTTTGTTTCCTGGAGGGACCCCAAGAGTGGC
TCCTGGTACGTTGAGACCCTGGACGACATCTTTGAGCAGTGGGCTCACTCTGAAGACCTG
CAGTCCCTCCTGCTTAGGGTCGCTAATGCTGTTTCGGTGAAAGGGATTTATAAACAGATG
CCTGGTTGCTTTAATTTCCTCCGGAAAAAACTTTTCTTTAAAACATCATAA
Chromosome Location
1
Locus
1p36.21
External Identifiers
ResourceLink
UniProtKB IDP55211
UniProtKB Entry NameCASP9_HUMAN
GeneCard IDCASP9
HGNC IDHGNC:1511
PDB ID(s)1JXQ, 1NW9, 2AR9, 3D9T, 3V3K, 3YGS, 4RHW, 5JUY, 5WVC, 5WVE
KEGG IDhsa:842
IUPHAR/Guide To Pharmacology ID1625
NCBI Gene ID842
General References
  1. Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM: ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996 Jul 12;271(28):16720-4. doi: 10.1074/jbc.271.28.16720. [Article]
  2. Srinivasula SM, Fernandes-Alnemri T, Zangrilli J, Robertson N, Armstrong RC, Wang L, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES: The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem. 1996 Oct 25;271(43):27099-106. doi: 10.1074/jbc.271.43.27099. [Article]
  3. Hadano S, Nasir J, Nichol K, Rasper DM, Vaillancourt JP, Sherer SW, Beatty BG, Ikeda JE, Nicholson DW, Hayden MR: Genomic organization of the human caspase-9 gene on Chromosome 1p36. 1-p36.3. Mamm Genome. 1999 Jul;10(7):757-60. doi: 10.1007/s003359901086. [Article]
  4. Srinivasula SM, Ahmad M, Guo Y, Zhan Y, Lazebnik Y, Fernandes-Alnemri T, Alnemri ES: Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res. 1999 Mar 1;59(5):999-1002. [Article]
  5. Seol DW, Billiar TR: A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis. J Biol Chem. 1999 Jan 22;274(4):2072-6. doi: 10.1074/jbc.274.4.2072. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Pamidronic acidapprovedunknowntargetactivatorDetails