Aquaporin-7

BE0010003ProteinHumansAQP7

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11952783, PubMed:30420639, PubMed:30423801, PubMed:36737436, PubMed:9405233). It is acted on by 4 drugs in DrugBank.

Gene name
AQP7
UniProtKB entry
O14520Swiss-Prot
Cellular location
Cell membrane
Residues / weight
342 residues · 37,231 Da
Also known as
AQP-7 · AQP7L · AQP9 · AQPap · Aquaglyceroporin-7

Resolves to

Protein
UniProtO14520UniProt nameAQP7_HUMAN
Gene
HGNCHGNC:640NCBI Gene364GeneCardsAQP7
Pharmacology
KEGGhsa:364
Structure
PDB6KXWPDB6N1GPDB6QZI
Drugs

What you can answer from here — as of May 27, 2020

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aquaporin-7, how selective are they, and which programs against it are still in active trials?

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