DNA (cytosine-5)-methyltransferase 3B

BE0010009ProteinHumansDNMT3B

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. It is acted on by 3 drugs in DrugBank.

Gene name
DNMT3B
UniProtKB entry
Q9UBC3Swiss-Prot
Cellular location
Nucleus
Residues / weight
853 residues · 95,750 Da
Also known as
2.1.1.37 · DNA methyltransferase HsaIIIB · DNA MTase HsaIIIB · Dnmt3b · M.HsaIIIB

Resolves to

Protein
UniProtQ9UBC3UniProt nameDNM3B_HUMAN
Gene
HGNCHGNC:2979NCBI Gene1789GeneCardsDNMT3B
Pharmacology
KEGGhsa:1789
Structure
PDB3FLGPDB3QKJPDB5CIU
Drugs

What you can answer from here — as of July 14, 2020

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA (cytosine-5)-methyltransferase 3B, how selective are they, and which programs against it are still in active trials?

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