Replicase polyprotein 1a

BE0010017ProteinSARS-CoV-2

Replicase polyprotein 1a Multifunctional protein involved in the transcription and replication of viral RNAs. It is acted on by 3 drugs in DrugBank.

UniProtKB entry
P0DTC1Swiss-Prot
Cellular location
Host membrane
Residues / weight
4,405 residues · 489,985 Da
Also known as
ORF1a polyprotein · pp1a

Resolves to

Protein
UniProtP0DTC1UniProt nameR1A_SARS2
Gene
NCBI Gene43740578
Structure
PDB6Y2EPDB6Y2FPDB6Y2G
Drugs

What you can answer from here — as of September 03, 2020

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
18GO termsFunction, process and component, as structured annotations
Sign in
13Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
4+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Replicase polyprotein 1a, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In