DB15796ExperimentalSmall molecule
GC-376 is a 3C-like protease (3CLpro or Mpro) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells . The compound... The compound is known as a direct acting antiviral (DAA) for coronaviruses, and was initially developed using structure-guided design to combat MERS-Cov infections.
- Formula / weight
- C21H31N3O8S · 485.55 g/mol (avg)
- Code names
- GC-376 free acid
Resolves to
Structure
InChIKey
BSPZFJDYQHDZNR-ASPXRTSYSA-NSMILESCC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CC1CCNC1=O)C(O)S(O)(=O)=OWhat you can answer from here — as of August 30, 2026
5Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with GC-376, and which of those have an active Phase 3 trial?
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