GC-373

DB15797ExperimentalSmall molecule

GC-373 is a peptide aldehyde which is metabolized from the bisulfide adduct, GC-376 free acid . It is an inhibitor of Mpro (otherwise known as 3CLpro), a viral encoded protease... GC-373 has been shown to inhibit the Mpro target in various coronavirus strains, including feline, mink, and ferret Mpro.

Mechanism: Pharmacologically active on Replicase polyprotein 1ab and Replicase polyprotein 1a
Curator reviewed
Formula / weight: C₂₁H₂₉N₃O₅ · 403.479 g/mol (avg)
Code names: GC-373

Resolves to

Compound

UNIIW9SVW656LQChEMBLCHEMBL1821850

Structure

InChIKeyQYENXTYKACLCGO-FQECFTEESA-NSMILESCC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CC1CCNC1=O)C=O

Targets

K9N7C7repK9N638Replicase polyprotein 1aP0DTD1repP0DTC1Replicase polyprotein 1aQ98VG9rep

What you can answer from here — as of December 14, 2023

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with GC-373, and which of those have an active Phase 3 trial?

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