GC-373
Identification
- Generic Name
- GC-373
- DrugBank Accession Number
- DB15797
- Background
GC-373 is a peptide aldehyde which is metabolized from the bisulfide adduct, GC-376 free acid1,2. It is an inhibitor of Mpro (otherwise known as 3CLpro), a viral encoded protease that cleaves and activates functional proteins involved in viral replication and transcription2. GC-373 has been shown to inhibit the Mpro target in various coronavirus strains, including feline, mink, and ferret Mpro 3. Along with its prodrug, GC-376, GC-373 was recently investigated in vitro in cell culture against SARS-Cov-2 Mpro 2. The results showed potent inhibition of the target, suggesting that GC-373 holds therapeutic potential for Covid-192.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 403.479
Monoisotopic: 403.210721046 - Chemical Formula
- C21H29N3O5
- Synonyms
- Not Available
- External IDs
- GC-373
- GC373
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism AReplicase polyprotein 1ab inhibitorMiddle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) AReplicase polyprotein 1a inhibitorMiddle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) UReplicase polyprotein 1ab inhibitorSARS-CoV-2 UReplicase polyprotein 1a inhibitorSARS-CoV-2 UReplicase polyprotein 1ab inhibitorFeline coronavirus (strain FIPV WSU-79/1146) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- W9SVW656LQ
- CAS number
- Not Available
- InChI Key
- QYENXTYKACLCGO-FQECFTEESA-N
- InChI
- InChI=1S/C21H29N3O5/c1-14(2)10-18(24-21(28)29-13-15-6-4-3-5-7-15)20(27)23-17(12-25)11-16-8-9-22-19(16)26/h3-7,12,14,16-18H,8-11,13H2,1-2H3,(H,22,26)(H,23,27)(H,24,28)/t16?,17-,18-/m0/s1
- IUPAC Name
- benzyl N-[(1S)-3-methyl-1-{[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]carbamoyl}butyl]carbamate
- SMILES
- CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CC1CCNC1=O)C=O
References
- General References
- Kim Y, Shivanna V, Narayanan S, Prior AM, Weerasekara S, Hua DH, Kankanamalage AC, Groutas WC, Chang KO: Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses. J Virol. 2015 May;89(9):4942-50. doi: 10.1128/JVI.03688-14. Epub 2015 Feb 18. [Article]
- Vuong W, Khan MB, Fischer C, Arutyunova E, Lamer T, Shields J, Saffran HA, McKay RT, van Belkum MJ, Joyce MA, Young HS, Tyrrell DL, Vederas JC, Lemieux MJ: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nat Commun. 2020 Aug 27;11(1):4282. doi: 10.1038/s41467-020-18096-2. [Article]
- Perera KD, Galasiti Kankanamalage AC, Rathnayake AD, Honeyfield A, Groutas W, Chang KO, Kim Y: Protease inhibitors broadly effective against feline, ferret and mink coronaviruses. Antiviral Res. 2018 Dec;160:79-86. doi: 10.1016/j.antiviral.2018.10.015. Epub 2018 Oct 19. [Article]
- External Links
- ChemSpider
- 26617691
- BindingDB
- 476983
- ChEMBL
- CHEMBL1821850
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 1.28 Chemaxon pKa (Strongest Acidic) 12.68 Chemaxon pKa (Strongest Basic) 3.13 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 113.6 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 106.58 m3·mol-1 Chemaxon Polarizability 42.88 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0udm-4191300000-6a07a86e6c59fe29d1ed Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-0940000000-825f40dd4db95f4e57ab Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-01ox-7921000000-69f3e8e58b9f3dccb70a Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-004i-1690000000-37c47086584d5710bfbb Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0006-9200000000-ac8155d144ba65c47529 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0bt9-2910000000-fa114f39be64205284e0 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
- Kind
- Protein
- Organism
- Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
- Specific Function
- Atp binding
- Gene Name
- rep
- Uniprot ID
- K9N7C7
- Uniprot Name
- Replicase polyprotein 1ab
- Molecular Weight
- 789556.615 Da
- Kind
- Protein
- Organism
- Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
- Specific Function
- Cysteine-type endopeptidase activity
- Gene Name
- Not Available
- Uniprot ID
- K9N638
- Uniprot Name
- Replicase polyprotein 1a
- Molecular Weight
- 486054.32 Da
- Kind
- Protein
- Organism
- SARS-CoV-2
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Replicase polyprotein 1ab Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein.
- Specific Function
- Atp binding
- Gene Name
- rep
- Uniprot ID
- P0DTD1
- Uniprot Name
- Replicase polyprotein 1ab
- Molecular Weight
- 794051.285 Da
- Kind
- Protein
- Organism
- SARS-CoV-2
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Replicase polyprotein 1a Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein.
- Specific Function
- Cysteine-type endopeptidase activity
- Gene Name
- Not Available
- Uniprot ID
- P0DTC1
- Uniprot Name
- Replicase polyprotein 1a
- Molecular Weight
- 489984.88 Da
- Kind
- Protein
- Organism
- Feline coronavirus (strain FIPV WSU-79/1146)
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
- Specific Function
- Atp binding
- Gene Name
- rep
- Uniprot ID
- Q98VG9
- Uniprot Name
- Replicase polyprotein 1ab
- Molecular Weight
- 751190.21 Da
Drug created at September 03, 2020 15:38 / Updated at December 14, 2023 19:14