Replicase polyprotein 1ab

BE0010018ProteinFeline coronavirus (strain FIPV WSU-79/1146)rep

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for... It is acted on by 2 drugs in DrugBank.

Gene name
rep
UniProtKB entry
Q98VG9Swiss-Prot
Cellular location
Host membrane
Residues / weight
6,709 residues · 751,190 Da
Also known as
ORF1ab polyprotein · pp1ab

Resolves to

Protein
UniProtQ98VG9UniProt nameR1AB_FIPV
Structure
PDB3ETIPDB3EW5PDB3GZF
Drugs

What you can answer from here — as of September 03, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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13Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Replicase polyprotein 1ab, and which indications are they being tested in?

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