Replicase polyprotein 1ab

BE0010019ProteinMiddle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)rep

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for... It is acted on by 3 drugs in DrugBank.

Gene name
rep
UniProtKB entry
K9N7C7Swiss-Prot
Cellular location
Host membrane
Residues / weight
7,078 residues · 789,557 Da
Also known as
ORF1ab polyprotein · pp1ab

Resolves to

Protein
UniProtK9N7C7UniProt nameR1AB_MERS1
Structure
PDB4WURPDB5HOLPDB5KO3
Drugs

What you can answer from here — as of September 03, 2020

3DrugsApproved to experimental, with action, bond type and pharmacological action
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31GO termsFunction, process and component, as structured annotations
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15Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Replicase polyprotein 1ab, how selective are they, and which programs against it are still in active trials?

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