Replicase polyprotein 1a

BE0010020ProteinMiddle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for... It is acted on by 2 drugs in DrugBank.

UniProtKB entry
K9N638Swiss-Prot
Cellular location
Host membrane
Residues / weight
4,391 residues · 486,054 Da
Also known as
ORF1a polyprotein · pp1a

Resolves to

Protein
UniProtK9N638UniProt nameR1A_MERS1
Structure
PDB4R3DPDB5DUSPDB5HIH
Drugs

What you can answer from here — as of September 03, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
17GO termsFunction, process and component, as structured annotations
Sign in
10Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
2+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Replicase polyprotein 1a, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In