IgG receptor FcRn large subunit p51

BE0010182ProteinHumansFCGRT

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. It is acted on by 9 drugs in DrugBank.

Gene name
FCGRT
UniProtKB entry
P55899Swiss-Prot
Cellular location
Cell membrane
Residues / weight
365 residues · 39,743 Da
Also known as
FCRN · IgG Fc fragment receptor transporter alpha chain · Neonatal Fc receptor

Resolves to

Protein
UniProtP55899UniProt nameFCGRN_HUMAN
Gene
HGNCHGNC:3621NCBI Gene2217GeneCardsFCGRT
Pharmacology
IUPHAR/GtoPdb2985KEGGhsa:2217
Structure
PDB1EXUPDB3M17PDB3M1B
Drugs

What you can answer from here — as of December 21, 2021

9DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on IgG receptor FcRn large subunit p51, how selective are they, and which programs against it are still in active trials?

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