Insulin efsitora alfa

Insulin efsitora alfa regulates glucose metabolism; insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin also inhibits lipolysis and proteolysis and enhances protein synthesis. The protracted time-action profile of insulin efsitora alfa results from reduced renal clearance due to its relatively large molecular size, inhibition of degradation due to binding at the neonatal Fc receptor, and reduced affinity relative to human insulin for the insulin receptor, which decreases receptor-mediated clearance. Once engaged with the insulin receptor, insulin efsitora alfa produces the same pharmacological effects as human insulin.