Asialoglycoprotein receptor 1

BE0010188ProteinHumansASGR1

Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. It is acted on by 7 drugs in DrugBank.

Gene name
ASGR1
UniProtKB entry
P07306Swiss-Prot
Cellular location
Cell membrane
Residues / weight
291 residues · 33,186 Da
Also known as
ASGP-R 1 · ASGPR 1 · C-type lectin domain family 4 member H1 · CLEC4H1 · Hepatic lectin H1

Resolves to

Protein
UniProtP07306UniProt nameASGR1_HUMAN
Gene
HGNCHGNC:742NCBI Gene432GeneCardsASGR1
Pharmacology
KEGGhsa:432
Structure
PDB1DV8PDB5JPVPDB5JQ1
Drugs

What you can answer from here — as of February 01, 2022

7DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Asialoglycoprotein receptor 1, how selective are they, and which programs against it are still in active trials?

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