Asialoglycoprotein receptor 1
Details
- Name
- Asialoglycoprotein receptor 1
- Kind
- protein
- Synonyms
- ASGP-R 1
- ASGPR 1
- C-type lectin domain family 4 member H1
- CLEC4H1
- Hepatic lectin H1
- HL-1
- Gene Name
- ASGR1
- UniProtKB Entry
- P07306Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052776|Asialoglycoprotein receptor 1 MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIG SQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDH SSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADN YCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQ PDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL
- Number of residues
- 291
- Molecular Weight
- 33185.86
- Theoretical pI
- Not Available
- GO Classification
- Functionsasialoglycoprotein receptor activity / identical protein binding / metal ion bindingProcessescellular response to extracellular stimulus / receptor-mediated endocytosisComponentsextracellular region / plasma membrane
- General Function
- Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface
- Specific Function
- Asialoglycoprotein receptor activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 41-61
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0052777|Asialoglycoprotein receptor 1 (ASGR1) ATGACCAAGGAGTATCAAGACCTTCAGCATCTGGACAATGAGGAGAGTGACCACCATCAG CTCAGAAAAGGGCCACCTCCTCCCCAGCCCCTCCTGCAGCGTCTCTGCTCCGGACCTCGC CTCCTCCTGCTCTCCCTGGGCCTCAGCCTCCTGCTGCTTGTGGTTGTCTGTGTGATCGGA TCCCAAAACTCCCAGCTGCAGGAGGAGCTGCGGGGCCTGAGAGAGACGTTCAGCAACTTC ACAGCGAGCACGGAGGCCCAGGTCAAGGGCTTGAGCACCCAGGGAGGCAATGTGGGAAGA AAGATGAAGTCGCTAGAGTCCCAGCTGGAGAAACAGCAGAAGGACCTGAGTGAAGATCAC TCCAGCCTGCTGCTCCACGTGAAGCAGTTCGTGTCTGACCTGCGGAGCCTGAGCTGTCAG ATGGCGGCGCTCCAGGGCAATGGCTCAGAAAGGACCTGCTGCCCGGTCAACTGGGTGGAG CACGAGCGCAGCTGCTACTGGTTCTCTCGCTCCGGGAAGGCCTGGGCTGACGCCGACAAC TACTGCCGGCTGGAGGACGCGCACCTGGTGGTGGTCACGTCCTGGGAGGAGCAGAAATTT GTCCAGCACCACATAGGCCCTGTGAACACCTGGATGGGCCTCCACGACCAAAACGGGCCC TGGAAGTGGGTGGACGGGACGGACTACGAGACGGGCTTCAAGAACTGGAGGCCGGAGCAG CCGGACGACTGGTACGGCCACGGGCTCGGAGGAGGCGAGGACTGTGCCCACTTCACCGAC GACGGCCGCTGGAACGACGACGTCTGCCAGAGGCCCTACCGCTGGGTCTGCGAGACAGAG CTGGACAAGGCCAGCCAGGAGCCACCTCTCCTTTAA
- Chromosome Location
- 17
- Locus
- 17p13.1
- External Identifiers
Resource Link UniProtKB ID P07306 UniProtKB Entry Name ASGR1_HUMAN GeneCard ID ASGR1 HGNC ID HGNC:742 PDB ID(s) 1DV8, 5JPV, 5JQ1, 6YAU KEGG ID hsa:432 NCBI Gene ID 432 - General References
- Spiess M, Schwartz AL, Lodish HF: Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion. J Biol Chem. 1985 Feb 25;260(4):1979-82. [Article]
- Spiess M, Lodish HF: An internal signal sequence: the asialoglycoprotein receptor membrane anchor. Cell. 1986 Jan 17;44(1):177-85. doi: 10.1016/0092-8674(86)90496-4. [Article]
- Liu J, Hu B, Yang Y, Ma Z, Yu Y, Liu S, Wang B, Zhao X, Lu M, Yang D: A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes. PLoS One. 2010 Sep 23;5(9):e12934. doi: 10.1371/journal.pone.0012934. [Article]
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- Zeng FY, Weigel PH: Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits. J Biol Chem. 1996 Dec 13;271(50):32454-60. doi: 10.1074/jbc.271.50.32454. [Article]
- Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR: Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. Genomics. 2001 Sep;77(1-2):58-64. [Article]
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- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Zhang L, Tian Y, Wen Z, Zhang F, Qi Y, Huang W, Zhang H, Wang Y: Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2. J Med Virol. 2016 Dec;88(12):2186-2195. doi: 10.1002/jmv.24570. Epub 2016 May 13. [Article]
- Meier M, Bider MD, Malashkevich VN, Spiess M, Burkhard P: Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor. J Mol Biol. 2000 Jul 21;300(4):857-65. doi: 10.1006/jmbi.2000.3853. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Von Willebrand factor human approved, investigational unknown target ligand Details