T-cell-specific surface glycoprotein CD28

BE0010325ProteinHumansCD28

Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). It is acted on by 6 drugs in DrugBank.

Gene name
CD28
UniProtKB entry
P10747Swiss-Prot
Cellular location
Cell membrane
Residues / weight
220 residues · 25,066 Da
Also known as
TP44

Resolves to

Protein
UniProtP10747UniProt nameCD28_HUMAN
Gene
HGNCHGNC:1653NCBI Gene940GeneCardsCD28
Pharmacology
IUPHAR/GtoPdb2863KEGGhsa:940
Structure
PDB1YJDPDB3WA4PDB5AUL
Drugs

What you can answer from here — as of October 31, 2023

6DrugsApproved to experimental, with action, bond type and pharmacological action
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43Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on T-cell-specific surface glycoprotein CD28, how selective are they, and which programs against it are still in active trials?

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