Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

BE0010402ProteinHumansGNE

Bifunctional enzyme that possesses both UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of... It is acted on by 2 drugs in DrugBank.

Gene name
GNE
UniProtKB entry
Q9Y223Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
722 residues · 79,274 Da
Also known as
GLCNE · IBM2 · UDP-GlcNAc-2-epimerase/ManAc kinase

Resolves to

Protein
UniProtQ9Y223UniProt nameGLCNE_HUMAN
Gene
HGNCHGNC:23657NCBI Gene10020GeneCardsGNE
Pharmacology
KEGGhsa:10020
Structure
PDB2YHWPDB2YHYPDB2YI1
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, and which indications are they being tested in?

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