Ribosomal protein S6 kinase beta-1

BE0010424ProteinHumansRPS6KB1

Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604,... It is acted on by 4 drugs in DrugBank.

Gene name
RPS6KB1
UniProtKB entry
P23443Swiss-Prot
Cellular location
Synapse, synaptosome
Residues / weight
525 residues · 59,139 Da
Also known as
2.7.11.1 · 70 kDa ribosomal protein S6 kinase 1 · p70 ribosomal S6 kinase alpha · p70 S6 kinase alpha · p70 S6K-alpha

Resolves to

Protein
UniProtP23443UniProt nameKS6B1_HUMAN
Gene
HGNCHGNC:10436NCBI Gene6198GeneCardsRPS6KB1
Pharmacology
IUPHAR/GtoPdb1525KEGGhsa:6198
Structure
PDB3A60PDB3A61PDB3A62
Drugs

What you can answer from here — as of October 31, 2023

4DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ribosomal protein S6 kinase beta-1, and which indications are they being tested in?

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