Ectonucleoside triphosphate diphosphohydrolase 1

BE0010475ProteinHumansENTPD1

Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). It is acted on by 4 drugs in DrugBank.

Gene name
ENTPD1
UniProtKB entry
P49961Swiss-Prot
Cellular location
Membrane
Residues / weight
510 residues · 57,964 Da
Also known as
3.6.1.5 · ATP diphosphohydrolase · ATP-DPH · ATPDase · CD39

Resolves to

Protein
UniProtP49961UniProt nameENTP1_HUMAN
Gene
HGNCHGNC:3363NCBI Gene953GeneCardsENTPD1
Pharmacology
IUPHAR/GtoPdb2888KEGGhsa:953
Drugs

What you can answer from here — as of October 31, 2023

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ectonucleoside triphosphate diphosphohydrolase 1, how selective are they, and which programs against it are still in active trials?

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