Baculoviral IAP repeat-containing protein 2

BE0010675ProteinHumansBIRC2

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. It is acted on by 5 drugs in DrugBank.

Gene name
BIRC2
UniProtKB entry
Q13490Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
618 residues · 69,899 Da
Also known as
2.3.2.27 · API1 · C-IAP1 · Cellular inhibitor of apoptosis 1 · hIAP-2

Resolves to

Protein
UniProtQ13490UniProt nameBIRC2_HUMAN
Gene
HGNCHGNC:590NCBI Gene329GeneCardsBIRC2
Pharmacology
IUPHAR/GtoPdb2791KEGGhsa:329
Structure
PDB1QBHPDB2L9MPDB3D9T
Drugs

What you can answer from here — as of October 31, 2023

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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40GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Baculoviral IAP repeat-containing protein 2, and which indications are they being tested in?

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