DNA polymerase subunit gamma-1

BE0010884ProteinHumansPOLG

Catalytic subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). It is acted on by 1 drug in DrugBank.

Gene name
POLG
UniProtKB entry
P54098Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
1,239 residues · 139,561 Da
Also known as
2.7.7.7 · 3'-5' exodeoxyribonuclease · 5'-deoxyribose-phosphate lyase · MDP1 · Mitochondrial DNA polymerase catalytic subunit

Resolves to

Protein
UniProtP54098UniProt nameDPOG1_HUMAN
Gene
HGNCHGNC:9179NCBI Gene5428GeneCardsPOLG
Pharmacology
KEGGhsa:5428
Structure
PDB3IKMPDB4ZTUPDB4ZTZ
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase subunit gamma-1, how selective are they, and which programs against it are still in active trials?

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