Prostaglandin E synthase

BE0011075ProteinHumansPTGES

Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. It is acted on by 5 drugs in DrugBank.

Gene name
PTGES
UniProtKB entry
O14684Swiss-Prot
Cellular location
Membrane
Residues / weight
152 residues · 17,102 Da
Also known as
5.3.99.3 · Glutathione peroxidase PTGES · Glutathione transferase PTGES · MGST1-L1 · MGST1L1

Resolves to

Protein
UniProtO14684UniProt namePTGES_HUMAN
Gene
HGNCHGNC:9599NCBI Gene9536GeneCardsPTGES
Pharmacology
IUPHAR/GtoPdb1377KEGGhsa:9536
Structure
PDB3DWWPDB4AL0PDB4AL1
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
18GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Prostaglandin E synthase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In