Prostaglandin E synthase

Details

Name
Prostaglandin E synthase
Kind
protein
Synonyms
  • 5.3.99.3
  • Glutathione peroxidase PTGES
  • Glutathione transferase PTGES
  • MGST1-L1
  • MGST1L1
  • Microsomal glutathione S-transferase 1-like 1
  • Microsomal prostaglandin E synthase 1
  • MPGES-1
  • MPGES1
  • p53-induced gene 12 protein
  • PGES
  • PIG12
Gene Name
PTGES
UniProtKB Entry
O14684Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0019810|Prostaglandin E synthase
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
Number of residues
152
Molecular Weight
17102.135
Theoretical pI
Not Available
GO Classification
Not Available
General Function
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:18682561). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824)
Specific Function
glutathione binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
13-41 61-90 96-119 124-152
Cellular Location
Membrane
Gene sequence
Not Available
Chromosome Location
9
Locus
9q34.11
External Identifiers
ResourceLink
UniProtKB IDO14684
UniProtKB Entry NamePTGES_HUMAN
GeneCard IDPTGES
HGNC IDHGNC:9599
PDB ID(s)3DWW, 4AL0, 4AL1, 4BPM, 4WAB, 4YK5, 4YL0, 4YL1, 4YL3, 5BQG, 5BQH, 5BQI, 5K0I, 5T36, 5T37, 5TL9, 6VL4, 8PYV
KEGG IDhsa:9536
IUPHAR/Guide To Pharmacology ID1377
NCBI Gene ID9536
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
CrisdesalazineinvestigationalyestargetinhibitorDetails