Fructose-1,6-bisphosphatase isozyme 2

BE0011215ProteinHumansFBP2

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. It is acted on by 8 drugs in DrugBank.

Gene name
FBP2
UniProtKB entry
O00757Swiss-Prot
Cellular location
Cell junction
Residues / weight
339 residues · 36,743 Da
Also known as
3.1.3.11 · D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 · FBPase 2 · Muscle FBPase

Resolves to

Protein
UniProtO00757UniProt nameF16P2_HUMAN
Gene
HGNCHGNC:3607NCBI Gene8789GeneCardsFBP2
Pharmacology
KEGGhsa:8789
Structure
PDB3IFAPDB3IFCPDB4HE0
Drugs

What you can answer from here — as of September 03, 2024

8DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
8+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Fructose-1,6-bisphosphatase isozyme 2, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In