Fructose-1,6-bisphosphatase isozyme 2

BE0011215ProteinHumansFBP2

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. It is acted on by 8 drugs in DrugBank.

Gene name
FBP2
UniProtKB entry
O00757Swiss-Prot
Cellular location
Cell junction
Residues / weight
339 residues · 36,743 Da
Also known as
3.1.3.11 · D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 · FBPase 2 · Muscle FBPase

Resolves to

Protein
UniProtO00757UniProt nameF16P2_HUMAN
Gene
HGNCHGNC:3607NCBI Gene8789GeneCardsFBP2
Pharmacology
KEGGhsa:8789
Structure
PDB3IFAPDB3IFCPDB4HE0
Drugs

What you can answer from here — as of September 03, 2024

8DrugsApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Fructose-1,6-bisphosphatase isozyme 2, and which indications are they being tested in?

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