Fructose-1,6-bisphosphatase isozyme 2

Details

Name
Fructose-1,6-bisphosphatase isozyme 2
Kind
protein
Synonyms
  • 3.1.3.11
  • D-fructose-1,6-bisphosphate 1-phosphohydrolase 2
  • FBPase 2
  • Muscle FBPase
Gene Name
FBP2
UniProtKB Entry
O00757Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0054451|Fructose-1,6-bisphosphatase isozyme 2
MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLAHLYGI
AGSVNVTGDEVKKLDVLSNSLVINMVQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDP
LDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQ
GVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAP
YGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGT
QPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQAGS
Number of residues
339
Molecular Weight
36742.84
Theoretical pI
Not Available
GO Classification
Not Available
General Function
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate
Specific Function
fructose 1,6-bisphosphate 1-phosphatase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cell junction
Gene sequence
Not Available
Chromosome Location
9
Locus
9q22.32
External Identifiers
ResourceLink
UniProtKB IDO00757
UniProtKB Entry NameF16P2_HUMAN
GeneCard IDFBP2
HGNC IDHGNC:3607
PDB ID(s)3IFA, 3IFC, 4HE0, 4HE1, 4HE2, 5ET5, 5ET6, 5ET7, 5ET8, 5K54, 5K55, 5K56, 5L0A, 5Q0C
KEGG IDhsa:8789
NCBI Gene ID8789
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Fructose-6-phosphateexperimentalyestargetinhibitorDetails
2,5-Anhydroglucitol-1,6-BiphosphateexperimentalyestargetinhibitorDetails
4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDEexperimentalyestargetinhibitorDetails
4-(2-amino-1,3-thiazol-4-yl)phenolexperimentalyestargetinhibitorDetails
MB-07803investigationalyestargetmodulatorDetails