Stearoyl-CoA desaturase

BE0011229ProteinHumansSCD

Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). It is acted on by 3 drugs in DrugBank.

Gene name
SCD
UniProtKB entry
O00767Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
359 residues · 41,522 Da
Also known as
1.14.19.1 · Acyl-CoA desaturase · Delta-9 desaturase · Delta(9)-desaturase · FADS5

Resolves to

Protein
UniProtO00767UniProt nameSCD_HUMAN
Gene
HGNCHGNC:10571NCBI Gene6319GeneCardsSCD
Pharmacology
KEGGhsa:6319
Structure
PDB4ZYO
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Stearoyl-CoA desaturase, how selective are they, and which programs against it are still in active trials?

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