Dual specificity tyrosine-phosphorylation-regulated kinase 3

BE0011693ProteinHumansDYRK3

Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). It is acted on by 2 drugs in DrugBank.

Gene name
DYRK3
UniProtKB entry
O43781Swiss-Prot
Cellular location
Nucleus
Residues / weight
588 residues · 65,713 Da
Also known as
2.7.12.1 · REDK · Regulatory erythroid kinase

Resolves to

Protein
UniProtO43781UniProt nameDYRK3_HUMAN
Gene
HGNCHGNC:3094NCBI Gene8444GeneCardsDYRK3
Pharmacology
IUPHAR/GtoPdb2012KEGGhsa:8444
Structure
PDB5Y86
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dual specificity tyrosine-phosphorylation-regulated kinase 3, and which indications are they being tested in?

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