Polycomb protein EED

Details

Name
Polycomb protein EED
Kind
protein
Synonyms
  • Embryonic ectoderm development protein
  • hEED
  • WAIT-1
  • WD protein associating with integrin cytoplasmic tails 1
Gene Name
EED
UniProtKB Entry
O75530Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0055205|Polycomb protein EED
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
Number of residues
441
Molecular Weight
50197.24
Theoretical pI
Not Available
GO Classification
Not Available
General Function
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A
Specific Function
chromatin binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
Not Available
Chromosome Location
11
Locus
11q14.2
External Identifiers
ResourceLink
UniProtKB IDO75530
UniProtKB Entry NameEED_HUMAN
GeneCard IDEED
HGNC IDHGNC:3188
PDB ID(s)3IIW, 3IIY, 3IJ0, 3IJ1, 3IJC, 3JPX, 3JZG, 3JZH, 3JZN, 3K26, 3K27, 4W2R, 4X3E, 5GSA, 5H13, 5H14, 5H15, 5H17, 5H19, 5H24, 5H25, 5HYN, 5IJ7, 5IJ8, 5K0M, 5LS6, 5TTW, 5U5H, 5U5K, 5U5T, 5U62, 5U69, 5U6D, 5U8A, 5U8F, 5WG6, 5WP3, 5WUK, 6B3W, 6C23, 6C24, 6LO2, 6SFB, 6SFC, 6U4Y, 6V3X, 6V3Y, 6W7F, 6W7G, 6WKR, 6YVI, 6YVJ, 7KSO, 7KSR, 7KTP, 7KXT, 7MSB, 7MSD, 7P3C, 7P3G, 7P3J, 7QJG, 7QJU, 7QK4, 7SI4, 7SI5, 7TD5, 8FYH
KEGG IDhsa:8726
IUPHAR/Guide To Pharmacology ID2487
NCBI Gene ID8726
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
MAK-683investigationalyestargetinhibitorDetails