Sphingosine 1-phosphate receptor 2

BE0012208ProteinHumansS1PR2

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). It is acted on by 2 drugs in DrugBank.

Gene name
S1PR2
UniProtKB entry
O95136Swiss-Prot
Cellular location
Cell membrane
Residues / weight
353 residues · 38,867 Da
Also known as
EDG5 · Endothelial differentiation G protein-coupled receptor 5 · S1P receptor 2 · S1P receptor Edg-5 · S1P2

Resolves to

Protein
UniProtO95136UniProt nameS1PR2_HUMAN
Gene
HGNCHGNC:3169NCBI Gene9294GeneCardsS1PR2
Pharmacology
IUPHAR/GtoPdb276KEGGhsa:9294
Structure
PDB7T6B
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Sphingosine 1-phosphate receptor 2, and which indications are they being tested in?

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