Calmodulin-1

Details

Name
Calmodulin-1
Kind
protein
Synonyms
  • CALM
  • CAM
  • CAM1
Gene Name
CALM1
UniProtKB Entry
P0DP23Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0015487|Calmodulin-1
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Number of residues
149
Molecular Weight
16837.47
Theoretical pI
Not Available
GO Classification
Not Available
General Function
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335)
Specific Function
Adenylate cyclase activator activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm, cytoskeleton, spindle
Gene sequence
Not Available
Chromosome Location
19
Locus
19q13.32
External Identifiers
ResourceLink
UniProtKB IDP0DP23
UniProtKB Entry NameCALM1_HUMAN
GeneCard IDCALM1
HGNC IDHGNC:1442
PDB ID(s)1CDL, 1CLL, 1CTR, 1IWQ, 1J7O, 1J7P, 1K90, 1K93, 1L7Z, 1LVC, 1NKF, 1PK0, 1S26, 1SK6, 1SW8, 1UP5, 1WRZ, 1XFU, 1XFV, 1XFW, 1XFX, 1XFY, 1XFZ, 1Y6W, 1YR5, 1YRT, 1YRU, 1ZOT, 1ZUZ, 2BE6, 2F3Y, 2F3Z, 2HF5, 2I08, 2JZI, 2K0E, 2K0F, 2K0J, 2K61, 2KNE, 2KUG, 2KUH, 2L53, 2L7L, 2LGF, 2LL6, 2LL7, 2LQC, 2LQP, 2LV6, 2M0J, 2M0K, 2M55, 2MG5, 2N27, 2N6A, 2N77, 2N8J, 2R28, 2V01, 2V02, 2VAY, 2W73, 2WEL, 2X0G, 2Y4V, 3BYA, 3DVE, 3DVJ, 3DVK, 3DVM, 3EVV, 3EWT, 3EWV, 3G43, 3HR4, 3J41, 3O77, 3O78, 3OXQ, 3SUI, 3UCT, 3UCW, 3UCY, 4BW7, 4BW8, 4BYF, 4DCK, 4DJC, 4GOW, 4JPZ, 4JQ0, 4L79, 4LZX, 4M1L, 4OVN, 4Q57, 4Q5U, 4UMO, 4UPU, 4V0C, 5COC, 5DBR, 5DOW, 5DSU, 5GGM, 5I0I, 5J03, 5J8H, 5JQA, 5JTH, 5K7L, 5K8Q, 5OEO, 5TP5, 5TP6, 5V02, 5V03, 5V7X, 5WBX, 5WC5, 6B8L, 6B8M, 6B8N, 6B8P, 6B8Q, 6BUT, 6C1D, 6C1G, 6C1H, 6CNM, 6CNN, 6CNO, 6DAD, 6DAE, 6DAF, 6DAH, 6E2F, 6E2G, 6EEB, 6FEG, 6FEH, 6GDK, 6GDL, 6HCS, 6HR1, 6JI8, 6JII, 6JIU, 6JIY, 6JRS, 6JV2, 6K4K, 6K4L, 6K4R, 6M2W, 6M7H, 6MUD, 6MUE, 6N5W, 6O5G, 6OS4, 6PAW, 6PBX, 6PBY, 6TV7, 6U39, 6U3A, 6U3B, 6U3D, 6UZZ, 6V00, 6V01, 6X32, 6X33, 6X35, 6X36, 6XXX, 6XY3, 6XYR, 6Y4P, 6Y94, 6Y95, 6YA9, 6YNS, 6YNU, 6ZBI, 7AUG, 7BF1, 7BF2, 7KL5, 7L8V, 7PSZ, 7PU9, 7SHQ, 7SX3, 7SX4, 7T2Q, 7TCI, 7TCP, 7TZC, 7U9T, 7UA3, 7UA4, 7VMB, 7VUO, 7VUR, 7VUS, 7VUT, 7VUU, 7VVD, 7VVH, 7WJI, 7WR3, 7WR4, 7WR5, 7WZS, 7XN4, 7XN5, 7XN6, 7ZRP, 7ZRQ, 8AHS, 8B6Q, 8BFG, 8DGH, 8DGK, 8DUJ, 8DVE, 8EOW, 8EP0, 8EP1, 8FNY, 8FO6, 8GM4, 8GM5, 8IJK, 8J00, 8J01, 8J02, 8J03, 8J04, 8J05, 8J07, 8JFK, 8ODZ, 8OE0, 8OE4, 8PB1, 8SIK, 8SIM, 8SIN, 8UXL, 8UXM, 8W4U, 8X43, 8XYA, 8XYB
KEGG IDhsa:808
NCBI Gene ID808
General References
Not Available

Associated Data

Drug Relations
Not Available