Calmodulin-1

BE0012563ProteinHumansCALM1

Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). It is acted on by 9 drugs in DrugBank.

Gene name
CALM1
UniProtKB entry
P0DP23Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, spindle
Residues / weight
149 residues · 16,837 Da
Also known as
CALM · CAM · CAM1

Resolves to

Protein
UniProtP0DP23UniProt nameCALM1_HUMAN
Gene
HGNCHGNC:1442NCBI Gene808GeneCardsCALM1
Pharmacology
KEGGhsa:808
Structure
PDB12DKPDB1CDLPDB1CLL
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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51GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calmodulin-1, how selective are they, and which programs against it are still in active trials?

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