Calmodulin-1
Details
- Name
- Calmodulin-1
- Kind
- protein
- Synonyms
- CALM
- CAM
- CAM1
- Gene Name
- CALM1
- UniProtKB Entry
- P0DP23Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0015487|Calmodulin-1 MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYEEFVQMMTAK
- Number of residues
- 149
- Molecular Weight
- 16837.47
- Theoretical pI
- Not Available
- GO Classification
- Functionsadenylate cyclase activator activity / calcium channel inhibitor activity / calcium ion binding / calcium-dependent protein binding / protein kinase binding / protein phosphatase activator activity / protein serine/threonine kinase activator activity / titin binding / transmembrane transporter bindingProcessesautophagosome membrane docking / cellular response to interferon-beta / cellular response to type II interferon / detection of calcium ion / G protein-coupled receptor signaling pathway / G2/M transition of mitotic cell cycle / mitochondrion-endoplasmic reticulum membrane tethering / negative regulation of calcium ion export across plasma membrane / negative regulation of high voltage-gated calcium channel activity / negative regulation of peptidyl-threonine phosphorylation / negative regulation of ryanodine-sensitive calcium-release channel activity / organelle localization by membrane tethering / positive regulation of cyclic-nucleotide phosphodiesterase activity / positive regulation of peptidyl-threonine phosphorylation / positive regulation of phosphoprotein phosphatase activity / positive regulation of protein autophosphorylation / positive regulation of protein dephosphorylation / positive regulation of protein serine/threonine kinase activity / positive regulation of receptor signaling pathway via JAK-STAT / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of calcium-mediated signaling / regulation of cardiac muscle cell action potential / regulation of cardiac muscle contraction / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / regulation of cell communication by electrical coupling involved in cardiac conduction / regulation of cytokinesis / regulation of heart rate / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / regulation of ryanodine-sensitive calcium-release channel activity / response to calcium ion / substantia nigra developmentComponentscalcium channel complex / catalytic complex / centrosome / cytoplasm / cytosol / extracellular region / myelin sheath / nucleoplasm / nucleus / plasma membrane / protein-containing complex / sarcomere / sperm midpiece / spindle microtubule / spindle pole / vesicle / voltage-gated potassium channel complex
- General Function
- Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335)
- Specific Function
- adenylate cyclase activator activity
- Pfam Domain Function
- EF-hand_7 (PF13499)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm, cytoskeleton, spindle
- Gene sequence
- Not Available
- Chromosome Location
- 19
- Locus
- 19q13.32
- External Identifiers
- General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details tert-butanol experimental yes target inhibitor Details Trimethyllysine experimental yes target inhibitor Details Myristic acid experimental yes target inhibitor Details Acetate experimental yes target inhibitor Details Trifluoperazine approved, investigational yes target inhibitor Details Aprindine experimental yes target inhibitor Details Halofantrine approved yes target modulator Details