Tubulin alpha-3C chain

Details

Name
Tubulin alpha-3C chain
Kind
protein
Synonyms
  • 3.6.5.-
  • Alpha-tubulin 2
  • Alpha-tubulin 3C
  • TUBA2
  • Tubulin alpha-2 chain
Gene Name
TUBA3C
UniProtKB Entry
P0DPH7Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052884|Tubulin alpha-3C chain
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGVDSVEAEAEEGEEY
Number of residues
450
Molecular Weight
49959.145
Theoretical pI
Not Available
GO Classification
Functions
GTP binding / hydrolase activity / metal ion binding / structural constituent of cytoskeleton
Processes
microtubule cytoskeleton organization / mitotic cell cycle
Components
cytoplasm / microtubule / microtubule cytoskeleton / nucleus
General Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Specific Function
GTP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm, cytoskeleton
Gene sequence
Not Available
Chromosome Location
13
Locus
13q12.11
External Identifiers
ResourceLink
UniProtKB IDP0DPH7
UniProtKB Entry NameTBA3C_HUMAN
GeneCard IDTUBA3C
HGNC IDHGNC:12408
KEGG IDhsa:7278
NCBI Gene ID7278
General References
Not Available

Associated Data

Drug Relations
Not Available