Deoxyribonuclease-1

BE0012829ProteinHumansDNASE1

Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:11241278, PubMed:2251263, PubMed:2277032). It is acted on by 3 drugs in DrugBank.

Gene name
DNASE1
UniProtKB entry
P24855Swiss-Prot
Cellular location
Secreted
Residues / weight
282 residues · 31,433 Da
Also known as
3.1.21.1 · Deoxyribonuclease I · DNase I · DNL1 · DRNI

Resolves to

Protein
UniProtP24855UniProt nameDNAS1_HUMAN
Gene
HGNCHGNC:2956NCBI Gene1773GeneCardsDNASE1
Pharmacology
KEGGhsa:1773
Structure
PDB4AWN
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Deoxyribonuclease-1, how selective are they, and which programs against it are still in active trials?

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