Bromodomain-containing protein 2

Details

Name
Bromodomain-containing protein 2
Kind
protein
Synonyms
  • KIAA9001
  • O27.1.1
  • RING3
Gene Name
BRD2
UniProtKB Entry
P25440Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0056060|Bromodomain-containing protein 2
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
Number of residues
801
Molecular Weight
88059.96
Theoretical pI
Not Available
GO Classification
Not Available
General Function
Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000)
Specific Function
acetylation-dependent protein binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
Not Available
Chromosome Location
6
Locus
6p21.32
External Identifiers
ResourceLink
UniProtKB IDP25440
UniProtKB Entry NameBRD2_HUMAN
GeneCard IDBRD2
HGNC IDHGNC:1103
PDB ID(s)1X0J, 2DVQ, 2DVR, 2DVS, 2DVV, 2E3K, 2G4A, 2YDW, 2YEK, 3AQA, 3ONI, 4A9E, 4A9F, 4A9H, 4A9I, 4A9J, 4A9M, 4A9N, 4A9O, 4AKN, 4ALG, 4ALH, 4J1P, 4MR5, 4MR6, 4QEU, 4QEV, 4QEW, 4UYF, 4UYG, 4UYH, 5BT5, 5DFB, 5DFC, 5DFD, 5DW1, 5EK9, 5HEL, 5HEM, 5HEN, 5HFQ, 5IBN, 5IG6, 5N2L, 5O38, 5O39, 5O3A, 5O3B, 5O3C, 5O3D, 5O3E, 5O3F, 5O3G, 5O3H, 5O3I, 5S9O, 5U5S, 5U6V, 5UEW, 5XHE, 5XHK, 6CUI, 6DB0, 6DBC, 6DDI, 6DDJ, 6E6J, 6FFE, 6FFF, 6FFG, 6I80, 6I81, 6JKE, 6K04, 6K05, 6MO7, 6MO8, 6MO9, 6MOA, 6ONY, 6SWO, 6SWP, 6TQ1, 6TQ2, 6U61, 6U71, 6U8H, 6ULQ, 6ULT, 6VIY, 6WWB, 6YTM, 6Z7F, 6Z8P, 6ZB0, 6ZB1, 6ZB2, 7DPN, 7DPO, 7ENV, 7ENZ, 7EO5, 7JX7, 7L6D, 7L9G, 7L9J, 7L9K, 7LAK, 7NPY, 7NPZ, 7NQ0, 7NQ1, 7NQ2, 7NQ3, 7NQ5, 7NQ7, 7NQ8, 7NQ9, 7NQI, 7NQJ, 7OE4, 7OE5, 7OE6, 7OE8, 7OE9, 7OEP, 7OER, 7OES, 7OET, 7OGY, 7Q5O, 7USG, 7USH, 7USI, 7UU0, 7VRH, 7VRI, 7VRK, 7VRM, 7VRO, 7VRQ, 7VRZ, 7VS0, 7VS1, 7VSF, 7WLN, 7WMQ, 7WMU, 7WN5, 7WNA, 7WNI, 8B5G, 8B5H, 8B5I, 8B5J, 8CV7, 8DNQ, 8PX2, 8PX8, 8SB6, 8WYG
KEGG IDhsa:6046
IUPHAR/Guide To Pharmacology ID1944
NCBI Gene ID6046
General References
Not Available

Associated Data

Drug Relations
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