Bromodomain-containing protein 2

BE0012869ProteinHumansBRD2

Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). It is acted on by 8 drugs in DrugBank.

Gene name
BRD2
UniProtKB entry
P25440Swiss-Prot
Cellular location
Nucleus
Residues / weight
801 residues · 88,060 Da
Also known as
KIAA9001 · O27.1.1 · RING3

Resolves to

Protein
UniProtP25440UniProt nameBRD2_HUMAN
Gene
HGNCHGNC:1103NCBI Gene6046GeneCardsBRD2
Pharmacology
IUPHAR/GtoPdb1944KEGGhsa:6046
Structure
PDB1X0JPDB2DVQPDB2DVR
Drugs

What you can answer from here — as of September 03, 2024

8DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bromodomain-containing protein 2, and which indications are they being tested in?

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