INCB-057643

DB16054InvestigationalSmall molecule

INCB-057643 is under investigation in clinical trial NCT02959437 (Azacitidine Combined With Pembrolizumab and Epacadostat in Subjects With Advanced Solid Tumors (ECHO-206)).

Mechanism: Pharmacologically active on Bromodomain-containing protein 4, Bromodomain-containing protein 2, and Bromodomain-containing protein 3
Curator reviewed
Formula / weight: C₂₀H₂₁N₃O₅S · 415.46 g/mol (avg)
Code names: INCB-057643

Resolves to

Compound

UNII87TZD0JEBSCAS1820889-23-3

Structure

InChIKeyVZSAMEOETVNDQH-UHFFFAOYSA-NSMILESCN1C=C(C2=C(NC=C2)C1=O)C1=C2OC(C)(C)C(=O)N(C)C2=CC(=C1)S(C)(=O)=O

Targets

O60885BRD4P25440BRD2Q15059BRD3

What you can answer from here — as of July 08, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with INCB-057643, and which of those have an active Phase 3 trial?

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