Neurotensin receptor type 1
Details
- Name
- Neurotensin receptor type 1
- Kind
- protein
- Synonyms
- High-affinity levocabastine-insensitive neurotensin receptor
- NT-R-1
- NTR1
- NTRH
- NTRR
- Gene Name
- NTSR1
- UniProtKB Entry
- P30989Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0013691|Neurotensin receptor type 1 MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
- Number of residues
- 418
- Molecular Weight
- 46258.305
- Theoretical pI
- Not Available
- GO Classification
- FunctionsG protein-coupled neurotensin receptor activity / G protein-coupled receptor activity / identical protein binding / protein-containing complex bindingProcessesadult locomotory behavior / chemical synaptic transmission / D-aspartate import across plasma membrane / detection of temperature stimulus involved in sensory perception of pain / G protein-coupled receptor signaling pathway / inositol phosphate catabolic process / L-glutamate import across plasma membrane / learning / negative regulation of apoptotic process / negative regulation of release of sequestered calcium ion into cytosol / negative regulation of systemic arterial blood pressure / neuropeptide signaling pathway / positive regulation of apoptotic process / positive regulation of arachidonic acid secretion / positive regulation of gamma-aminobutyric acid secretion / positive regulation of gene expression / positive regulation of glutamate secretion / positive regulation of inhibitory postsynaptic potential / positive regulation of inositol phosphate biosynthetic process / positive regulation of release of sequestered calcium ion into cytosol / regulation of membrane depolarization / regulation of respiratory gaseous exchange / response to lipid / temperature homeostasisComponentscell surface / cytoplasmic side of plasma membrane / dendritic shaft / dendritic spine / endoplasmic reticulum / Golgi apparatus / membrane raft / perikaryon / plasma membrane / symmetric synapse / terminal bouton
- General Function
- G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:21725197, PubMed:23140271, PubMed:8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197)
- Specific Function
- G protein-coupled neurotensin receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 68-88 103-122 143-164 185-205 235-259 304-325 344-364
- Cellular Location
- Cell membrane
- Gene sequence
- Not Available
- Chromosome Location
- 20
- Locus
- 20q13.33
- External Identifiers
Resource Link UniProtKB ID P30989 UniProtKB Entry Name NTR1_HUMAN GeneCard ID NTSR1 HGNC ID HGNC:8039 PDB ID(s) 2LYW, 6OS9, 6OSA, 6PWC, 6UP7, 7UL2, 8JPB, 8JPC, 8JPF KEGG ID hsa:4923 IUPHAR/Guide To Pharmacology ID 309 NCBI Gene ID 4923 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Meclinertant investigational yes target antagonist Details