Neurotensin receptor type 1

Details

Name
Neurotensin receptor type 1
Kind
protein
Synonyms
  • High-affinity levocabastine-insensitive neurotensin receptor
  • NT-R-1
  • NTR1
  • NTRH
  • NTRR
Gene Name
NTSR1
UniProtKB Entry
P30989Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0013691|Neurotensin receptor type 1
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
Number of residues
418
Molecular Weight
46258.305
Theoretical pI
Not Available
GO Classification
Functions
G protein-coupled neurotensin receptor activity / G protein-coupled receptor activity / identical protein binding / protein-containing complex binding
Processes
adult locomotory behavior / chemical synaptic transmission / D-aspartate import across plasma membrane / detection of temperature stimulus involved in sensory perception of pain / G protein-coupled receptor signaling pathway / inositol phosphate catabolic process / L-glutamate import across plasma membrane / learning / negative regulation of apoptotic process / negative regulation of release of sequestered calcium ion into cytosol / negative regulation of systemic arterial blood pressure / neuropeptide signaling pathway / positive regulation of apoptotic process / positive regulation of arachidonic acid secretion / positive regulation of gamma-aminobutyric acid secretion / positive regulation of gene expression / positive regulation of glutamate secretion / positive regulation of inhibitory postsynaptic potential / positive regulation of inositol phosphate biosynthetic process / positive regulation of release of sequestered calcium ion into cytosol / regulation of membrane depolarization / regulation of respiratory gaseous exchange / response to lipid / temperature homeostasis
Components
cell surface / cytoplasmic side of plasma membrane / dendritic shaft / dendritic spine / endoplasmic reticulum / Golgi apparatus / membrane raft / perikaryon / plasma membrane / symmetric synapse / terminal bouton
General Function
G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:21725197, PubMed:23140271, PubMed:8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197)
Specific Function
G protein-coupled neurotensin receptor activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
68-88 103-122 143-164 185-205 235-259 304-325 344-364
Cellular Location
Cell membrane
Gene sequence
Not Available
Chromosome Location
20
Locus
20q13.33
External Identifiers
ResourceLink
UniProtKB IDP30989
UniProtKB Entry NameNTR1_HUMAN
GeneCard IDNTSR1
HGNC IDHGNC:8039
PDB ID(s)2LYW, 6OS9, 6OSA, 6PWC, 6UP7, 7UL2, 8JPB, 8JPC, 8JPF
KEGG IDhsa:4923
IUPHAR/Guide To Pharmacology ID309
NCBI Gene ID4923
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
MeclinertantinvestigationalyestargetantagonistDetails