Vasoactive intestinal polypeptide receptor 1
Details
- Name
- Vasoactive intestinal polypeptide receptor 1
- Kind
- protein
- Synonyms
- PACAP type II receptor
- PACAP-R-2
- PACAP-R2
- Pituitary adenylate cyclase-activating polypeptide type II receptor
- VIP-R-1
- VPAC1
- Gene Name
- VIPR1
- UniProtKB Entry
- P32241Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0056308|Vasoactive intestinal polypeptide receptor 1 MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENET IGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPI ACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMH LFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYL YTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGP ILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFF PDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRH PSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
- Number of residues
- 457
- Molecular Weight
- 51546.66
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38
- Specific Function
- G protein-coupled peptide receptor activity
- Pfam Domain Function
- Signal Regions
- 1-30
- Transmembrane Regions
- 143-167 175-194 217-240 255-276 293-316 342-361 374-393
- Cellular Location
- Cell membrane
- Gene sequence
- Not Available
- Chromosome Location
- 3
- Locus
- 3p22.1
- External Identifiers
Resource Link UniProtKB ID P32241 UniProtKB Entry Name VIPR1_HUMAN GeneCard ID VIPR1 HGNC ID HGNC:12694 PDB ID(s) 1OF2, 1OGT, 3B3I, 3B6S, 3DTX, 3HCV, 5DEF, 5DEG, 5IB1, 5IB2, 5IB3, 5IB4, 5IB5, 6VN7, 7ALO, 8E3Y, 8E3Z KEGG ID hsa:7433 IUPHAR/Guide To Pharmacology ID 371 NCBI Gene ID 7433 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Vasoactive intestinal peptide investigational yes target antagonist Details