Aviptadil

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Aviptadil
Accession Number
DB06260
Description
Not Available
Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 3255.75
Monoisotopic: 3253.691767464
Chemical Formula
C145H232N40O43S
Synonyms
  • Aviptadil
  • Porcine vasoactive intestinal octacosapeptide
  • Vasoactive intestinal octacosapeptide (pig)
  • Vasoactive intestinal octacosapeptide (swine)

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

International/Other Brands
Invicorp

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
A67JUW790C
CAS number
40077-57-4
InChI Key
OIDGWOIMPADMGM-GXSWRUKYSA-N
InChI
InChI=1S/C145H232N40O43S/c1-19-74(13)114(141(224)175-94(55-71(7)8)130(213)178-102(144(227)228)62-109(153)195)183-138(221)104(67-187)180-133(216)99(61-108(152)194)172-129(212)93(54-70(5)6)169-131(214)95(57-80-37-41-83(189)42-38-80)170-124(207)87(34-25-28-49-147)163-123(206)88(35-26-29-50-148)166-139(222)112(72(9)10)181-118(201)76(15)159-121(204)91(47-52-229-18)165-126(209)90(45-46-106(150)192)164-122(205)86(33-24-27-48-146)162-117(200)75(14)160-127(210)92(53-69(3)4)168-125(208)89(36-30-51-157-145(154)155)167-143(226)116(105(191)20-2)185-136(219)96(58-81-39-43-84(190)44-40-81)171-132(215)98(60-107(151)193)173-134(217)101(64-111(198)199)177-142(225)115(78(17)188)184-135(218)97(56-79-31-22-21-23-32-79)176-140(223)113(73(11)12)182-119(202)77(16)161-128(211)100(63-110(196)197)174-137(220)103(66-186)179-120(203)85(149)59-82-65-156-68-158-82/h21-23,31-32,37-44,65,68-78,85-105,112-116,186-191H,19-20,24-30,33-36,45-64,66-67,146-149H2,1-18H3,(H2,150,192)(H2,151,193)(H2,152,194)(H2,153,195)(H,156,158)(H,159,204)(H,160,210)(H,161,211)(H,162,200)(H,163,206)(H,164,205)(H,165,209)(H,166,222)(H,167,226)(H,168,208)(H,169,214)(H,170,207)(H,171,215)(H,172,212)(H,173,217)(H,174,220)(H,175,224)(H,176,223)(H,177,225)(H,178,213)(H,179,203)(H,180,216)(H,181,201)(H,182,202)(H,183,221)(H,184,218)(H,185,219)(H,196,197)(H,198,199)(H,227,228)(H4,154,155,157)/t74-,75-,76-,77-,78+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105+,112-,113-,114-,115-,116-/m0/s1
IUPAC Name
(3S)-3-{[(1S)-1-{[(1S)-1-{[(1S,2R)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-2-carbamoyl-1-{[(1S)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-2-carbamoyl-1-carboxyethyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-hydroxyethyl]carbamoyl}ethyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}pentyl]carbamoyl}pentyl]carbamoyl}-2-methylpropyl]carbamoyl}ethyl]carbamoyl}-3-(methylsulfanyl)propyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}pentyl]carbamoyl}ethyl]carbamoyl}-3-methylbutyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-hydroxybutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-carbamoylethyl]carbamoyl}-3-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanamido]-3-hydroxypropanamido]-3-carboxypropanamido]propanamido]-3-methylbutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]propanoic acid
SMILES
CC[[email protected]](C)[[email protected]](NC(=O)[[email protected]](CO)NC(=O)[[email protected]](CC(N)=O)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]](CC1=CC=C(O)C=C1)NC(=O)[[email protected]](CCCCN)NC(=O)[[email protected]](CCCCN)NC(=O)[[email protected]@H](NC(=O)[[email protected]](C)NC(=O)[[email protected]](CCSC)NC(=O)[[email protected]](CCC(N)=O)NC(=O)[[email protected]](CCCCN)NC(=O)[[email protected]](C)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]](CCCNC(N)=N)NC(=O)[[email protected]@H](NC(=O)[[email protected]](CC1=CC=C(O)C=C1)NC(=O)[[email protected]](CC(N)=O)NC(=O)[[email protected]](CC(O)=O)NC(=O)[[email protected]@H](NC(=O)[[email protected]](CC1=CC=CC=C1)NC(=O)[[email protected]@H](NC(=O)[[email protected]](C)NC(=O)[[email protected]](CC(O)=O)NC(=O)[[email protected]](CO)NC(=O)[[email protected]@H](N)CC1=CN=CN1)C(C)C)[[email protected]@H](C)O)[[email protected]](O)CC)C(C)C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CC(N)=O)C(O)=O

References

General References
  1. Keijzers GB: Aviptadil (Senatek). Curr Opin Investig Drugs. 2001 Apr;2(4):545-9. [PubMed:11566015]
ChemSpider
28528368
ChEMBL
CHEMBL2106041
Wikipedia
Aviptadil

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingTreatmentAcute Lung Injury (ALI) / Acute Respiratory Distress Syndrome (ARDS) / Critical COVID-19 With Respiratory Failure / Infections, Coronavirus / Novel Coronavirus Infectious Disease (COVID-19)1
2, 3Not Yet RecruitingTreatmentAcute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) / Acute Respiratory Distress Syndrome (ARDS) / ALI / COVID / COVID - 19 / Dyspnea / Novel Coronavirus Infectious Disease (COVID-19) / SARS-CoV 21
1Not Yet RecruitingTreatmentAcute Respiratory Distress Syndrome (ARDS) / Aviptadil / Infections, Coronavirus / Novel Coronavirus Infectious Disease (COVID-19)1
Not AvailableAvailableNot AvailableCritical COVID-19 With Respiratory Failure / Novel Coronavirus Infectious Disease (COVID-19)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0536 mg/mLALOGPS
logP-1.6ALOGPS
logP-21ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)2.94ChemAxon
pKa (Strongest Basic)11.9ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count51ChemAxon
Hydrogen Donor Count48ChemAxon
Polar Surface Area1386 Å2ChemAxon
Rotatable Bond Count110ChemAxon
Refractivity825.76 m3·mol-1ChemAxon
Polarizability336.94 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on March 19, 2008 10:19 / Updated on June 12, 2020 10:52

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Logo pink
Stay in the know!
As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages.
#DrugBankUpdates