Translation initiation factor eIF2B subunit beta

Details

Name
Translation initiation factor eIF2B subunit beta
Kind
protein
Synonyms
  • eIF2B GDP-GTP exchange factor subunit beta
  • EIF2BB
  • S20I15
  • S20III15
Gene Name
EIF2B2
UniProtKB Entry
P49770Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0056417|Translation initiation factor eIF2B subunit beta
MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMEL
IRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNE
DFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKE
AARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTIL
ANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEG
DILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL
Number of residues
351
Molecular Weight
38989.28
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / GTP binding / guanyl-nucleotide exchange factor activity / translation initiation factor activity
Processes
central nervous system development / cytoplasmic translational initiation / myelination / oligodendrocyte development / ovarian follicle development / regulation of translational initiation / response to glucose / response to heat / response to peptide hormone / T cell receptor signaling pathway / translational initiation
Components
cytoplasm / cytosol / eukaryotic translation initiation factor 2B complex
General Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)
Specific Function
ATP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm, cytosol
Gene sequence
Not Available
Chromosome Location
14
Locus
14q24.3
External Identifiers
ResourceLink
UniProtKB IDP49770
UniProtKB Entry NameEI2BB_HUMAN
GeneCard IDEIF2B2
HGNC IDHGNC:3258
PDB ID(s)6CAJ, 6EZO, 6K71, 6K72, 6O81, 6O85, 6O9Z, 7D43, 7D44, 7D45, 7D46, 7F64, 7F66, 7F67, 7KMF, 7L70, 7L7G, 7RLO, 7TRJ, 7VLK, 8TQO, 8TQZ
KEGG IDhsa:8892
NCBI Gene ID8892
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
PlinabulininvestigationalyestargetstimulatorDetails