Translation initiation factor eIF2B subunit beta

BE0013252ProteinHumansEIF2B2

Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). It is acted on by 1 drug in DrugBank.

Gene name
EIF2B2
UniProtKB entry
P49770Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
351 residues · 38,989 Da
Also known as
eIF2B GDP-GTP exchange factor subunit beta · EIF2BB · S20I15 · S20III15

Resolves to

Protein
UniProtP49770UniProt nameEI2BB_HUMAN
Gene
HGNCHGNC:3258NCBI Gene8892GeneCardsEIF2B2
Pharmacology
KEGGhsa:8892
Structure
PDB6CAJPDB6EZOPDB6K71
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
18GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Translation initiation factor eIF2B subunit beta, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In