Nuclear receptor ROR-gamma

BE0013275ProteinHumansRORC

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. It is acted on by 7 drugs in DrugBank.

Gene name
RORC
UniProtKB entry
P51449Swiss-Prot
Cellular location
Nucleus
Residues / weight
518 residues · 58,195 Da
Also known as
NR1F3 · Nuclear receptor RZR-gamma · Nuclear receptor subfamily 1 group F member 3 · RAR-related orphan receptor C · Retinoid-related orphan receptor-gamma

Resolves to

Protein
UniProtP51449UniProt nameRORG_HUMAN
Gene
HGNCHGNC:10260NCBI Gene6097GeneCardsRORC
Pharmacology
IUPHAR/GtoPdb600KEGGhsa:6097
Structure
PDB3B0WPDB3KYTPDB3L0J
Drugs

What you can answer from here — as of September 03, 2024

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nuclear receptor ROR-gamma, how selective are they, and which programs against it are still in active trials?

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