ATP-dependent 6-phosphofructokinase, platelet type

BE0013891ProteinHumansPFKP

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. It is acted on by 2 drugs in DrugBank.

Gene name
PFKP
UniProtKB entry
Q01813Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
784 residues · 85,595 Da
Also known as
2.7.1.11 · 6-phosphofructokinase type C · ATP-PFK · PFK-C · PFK-P

Resolves to

Protein
UniProtQ01813UniProt namePFKAP_HUMAN
Gene
HGNCHGNC:8878NCBI Gene5214GeneCardsPFKP
Pharmacology
KEGGhsa:5214
Structure
PDB4RH3PDB4U1RPDB4WL0
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-dependent 6-phosphofructokinase, platelet type, how selective are they, and which programs against it are still in active trials?

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