Hormone-sensitive lipase

BE0014016ProteinHumansLIPE

Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:15716583, PubMed:15955102, PubMed:19800417, PubMed:8812477). It is acted on by 5 drugs in DrugBank.

Gene name
LIPE
UniProtKB entry
Q05469Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,076 residues · 116,597 Da
Also known as
3.1.1.79 · HSL · Monoacylglycerol lipase LIPE · REH · Retinyl ester hydrolase

Resolves to

Protein
UniProtQ05469UniProt nameLIPS_HUMAN
Gene
HGNCHGNC:6621NCBI Gene3991GeneCardsLIPE
Pharmacology
IUPHAR/GtoPdb2593KEGGhsa:3991
Structure
PDB8ZVQ
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hormone-sensitive lipase, how selective are they, and which programs against it are still in active trials?

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