Oxybenzone

Identification

Summary

Oxybenzone is a sunscreen agent found in sunscreens that absorbs UV rays.

Brand Names
Meijer
Generic Name
Oxybenzone
DrugBank Accession Number
DB01428
Background

Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Weight
Average: 228.2433
Monoisotopic: 228.07864425
Chemical Formula
C14H12O3
Synonyms
  • 2-Benzoyl-5-methoxyphenol
  • 2-Hydroxy-4-methoxybenzophenone
  • 4-Methoxy-2-hydroxybenzophenone
  • Benzophenone-3
  • Oxibenzona
  • Oxybenzone
  • Oxybenzonum
External IDs
  • NSC-7778

Pharmacology

Indication

Used as an ingredient in sunscreen and other cosmetics.

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.

Mechanism of action

Oxybenzone absorbs UV-A ultraviolet rays, preventing them from reaching the skin.

TargetActionsOrganism
UProgesterone receptor
antagonist
Humans
UAndrogen receptor
antagonist
Humans
UEstrogen receptor alphaNot AvailableHumans
UEstrogen receptor betaNot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

In vivo studies show oxybenzone is abosorbed transdermally (through the skin) and is excreted in the urine.

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
AcetazolamideAcetazolamide may increase the excretion rate of Oxybenzone which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
AclidiniumOxybenzone may decrease the excretion rate of Aclidinium which could result in a higher serum level.
AcrivastineOxybenzone may decrease the excretion rate of Acrivastine which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
Adefovir dipivoxilAdefovir dipivoxil may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
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Food Interactions
No interactions found.

Products

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Active Moieties
NameKindUNIICASInChI Key
Benzophenoneunknown701M4TTV9O119-61-9RWCCWEUUXYIKHB-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Bebak Baby SunLotion17 g/200gTopicalSORA KOZMETIK SANAYI TICARET ANONIM SIRKETI2020-07-16Not applicableUS flag
Zep Sun Screen TowelsLiquid0.05 g/100gTopicalZep Inc.2013-05-012020-01-02US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
100 SPF CreamOxybenzone (6 % w/w) + Avobenzone (3 % w/w) + Homosalate (15 % w/w) + Octisalate (5 % w/w) + Octocrylene (10 % w/w)CreamTopicalVital Science A Div. Of/Une Div. De Valeant Canada Ltd/Ltee2010-06-032014-08-27Canada flag
1177, 1178 SunscreenOxybenzone (5 g/100g) + Homosalate (6 g/100g) + Octinoxate (7.5 g/100g) + Octisalate (5 g/100g)CreamTopicalDynarex2021-05-27Not applicableUS flag
14-day Skin Rescue SPF 30Oxybenzone (6 % w/w) + Avobenzone (3 % w/w) + Homosalate (4 % w/w) + Octisalate (5 % w/w) + Octocrylene (2.35 % w/w)CreamTopicalJohnson & Johnson2009-02-162013-07-31Canada flag
15 SPF Fps Premium SunscreenOxybenzone (2 % w/w) + Avobenzone (3 % w/w) + Ensulizole (2 % w/w) + Octocrylene (10 % w/w)LotionTopicalEmpack Spraytech Inc2005-05-042021-08-10Canada flag
15 SPF Fps Sunscreen Lotion Écran SolaireOxybenzone (3.0 % w/w) + Avobenzone (0.9 % w/w) + Octocrylene (3.0 % w/w)LotionTopicalEnergizer Canada Inc2007-03-012011-07-29Canada flag
15 SPF Sunscreen Uva/uvb Protection Oil-free Milky SprayOxybenzone (2.0 %) + Avobenzone (3.0 %) + Octinoxate (5.0 %) + Octisalate (3.0 %) + Octocrylene (2.0 %)EmulsionTopicalCoty Canada Inc.2009-02-232013-07-24Canada flag
15 SPF Sunscreen Uva/uvb Protection Vitalizing Age-defying CreamOxybenzone (3.0 %) + Avobenzone (3.0 %) + Octinoxate (7.5 %) + Octisalate (5.0 %) + Octocrylene (2.0 %)CreamTopicalCoty Canada Inc.2009-02-232013-07-24Canada flag
15 Spray Gel Sunscreen With Instant BronzerOxybenzone (0.5 %) + Avobenzone (2 %) + Octisalate (5 %) + Octocrylene (1.85 %)GelTopicalPrime Enterprises, Inc.2018-04-092020-03-31Canada flag
24K Bio-Brightening Skin Tone Moisturizer SPF 30Oxybenzone (3.1 g/100g) + Avobenzone (1.5 g/100g) + Homosalate (6.2 g/100g) + Octinoxate (7.4 g/100g) + Octisalate (5 g/100g)CreamTopicalVivo Per-lei, Inc.2014-10-032019-12-31US flag
24K Skin Tone Moisturizer SPF 30Oxybenzone (3.1 g/100g) + Avobenzone (1.5 g/100g) + Homosalate (6.2 g/100g) + Octinoxate (7.4 g/100g) + Octisalate (5.0 g/100g)CreamTopicalVivo Per-lei, Inc.2019-07-29Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
4362 First Aid KitOxybenzone (6 g/100mL) + Ammonia (0.045 g/0.3mL) + Avobenzone (1 g/100mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Homosalate (5 g/100mL) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Octinoxate (7.5 g/100mL) + Octisalate (5 g/100mL) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)KitOphthalmic; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
Alphaquin HPOxybenzone (50 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1g)CreamTopicalStratus Pharmaceuticals1993-01-012017-02-01US flag
CoreTex Professional Outdoor Skin Protection WalletOxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL)Gel; Kit; Lipstick; Liquid; Lotion; SwabTopicalCoreTex Products Inc2019-11-27Not applicableUS flag
CoreTex Professional Outdoor Skin Protection WalletOxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL)Gel; Kit; Lipstick; Liquid; Lotion; SwabTopicalCoreTex Products Inc2019-11-27Not applicableUS flag
CoreTex Professional Outdoor Skin Protection WalletOxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL)Gel; Kit; Lipstick; Liquid; Lotion; SwabTopicalCoreTex Products Inc2019-11-27Not applicableUS flag
Glytone Clarifying SunVanish with SunscreenOxybenzone (50 mg/1g) + Avobenzone (20 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1g) + Octocrylene (18.6 mg/1g)CreamTopicalGenesis Pharmaceutical, Inc.2012-06-132018-02-28US flag
Glytone SunVanish Skin LighteningOxybenzone (50 mg/1g) + Avobenzone (20 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1g) + Octocrylene (18.6 mg/1g)CreamTopicalPierre Fabre USA Inc.2012-06-132021-09-30US flag
Hydroquinone with sunscreensOxybenzone (20 mg/1g) + Dioxybenzone (30 mg/1g) + Hydroquinone (40 mg/1g) + Padimate O (80 mg/1g)CreamTopicalPreferreed Pharmaceuticals Inc.2012-01-302017-01-31US flag
Nu-derm Starter Set Normal-dry Skin Transformation SystemOxybenzone (55 mg/1g) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1mL) + Octinoxate (75 mg/1g) + Zinc oxide (90 mg/1mL)KitTopicalOMP, INC.2007-08-20Not applicableUS flag
Nu-derm Starter Set Normal-oily Skin Transformation SystemOxybenzone (55 mg/1g) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1mL) + Octinoxate (75 mg/1g) + Zinc oxide (90 mg/1mL)KitTopicalOMP, INC.2004-12-02Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzophenones
Direct Parent
Benzophenones
Alternative Parents
Diphenylmethanes / Aryl-phenylketones / Methoxyphenols / Phenoxy compounds / Methoxybenzenes / Benzoyl derivatives / Anisoles / Alkyl aryl ethers / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids
show 3 more
Substituents
1-hydroxy-2-unsubstituted benzenoid / 1-hydroxy-4-unsubstituted benzenoid / Alkyl aryl ether / Anisole / Aromatic homomonocyclic compound / Aryl ketone / Aryl-phenylketone / Benzophenone / Benzoyl / Diphenylmethane
show 12 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
monomethoxybenzene, hydroxybenzophenone (CHEBI:34283)
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
95OOS7VE0Y
CAS number
131-57-7
InChI Key
DXGLGDHPHMLXJC-UHFFFAOYSA-N
InChI
InChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3
IUPAC Name
2-benzoyl-5-methoxyphenol
SMILES
COC1=CC(O)=C(C=C1)C(=O)C1=CC=CC=C1

References

General References
  1. Gonzalez H, Farbrot A, Larko O, Wennberg AM: Percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiation. Br J Dermatol. 2006 Feb;154(2):337-40. [Article]
Human Metabolome Database
HMDB0015497
KEGG Drug
D05309
KEGG Compound
C14285
PubChem Compound
4632
PubChem Substance
46508419
ChemSpider
4471
BindingDB
50253134
RxNav
32673
ChEBI
34283
ChEMBL
CHEMBL1625
ZINC
ZINC000000136138
PharmGKB
PA164742933
Wikipedia
Oxybenzone
MSDS
Download (73.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedSupportive CareAtrophic Vaginitis / Endometrial Hyperplasia / Pelvic Organ Prolapse (POP)1
4CompletedSupportive CareSkin Irritation1
4CompletedTreatmentAcne Prone Skin1
4CompletedTreatmentActinic Keratosis (AK)1
4CompletedTreatmentChronic Hand Eczema (CHE)1
4CompletedTreatmentHypertrophic Cicatrix / Keloids Scars / Scars, Hypertrophic1
4CompletedTreatmentMelasma1
4RecruitingTreatmentBreast Cancer / Vulvo Vaginal Atrophy1
4TerminatedNot AvailableSkin Aging1
3CompletedTreatmentAtopic Dermatitis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Axia Medical Solutions LLC
  • Beaura SPA Parker Center
  • Body Sculpting Center
  • Cosmetic Laser Skin Care
  • Dermatech
  • Dulles Cosmetic Surgery and Skin Care Center
  • Fairfield County Plastic Surgery
  • Genesis Pharmaceutical Inc.
  • Legacy Pharmaceuticals Packaging LLC
  • Obagi Medical Products Inc.
  • Paul Goco MD
  • Plastic Surgery Associates PC
  • Puretek Corp.
  • Qualitest
  • River's Edge Pharmaceuticals
  • Rulian Md Peter
  • Schooler Medical Professionals
  • Sheffield Laboratories Div Faria Limited LLC
  • Sonar Products Inc.
  • Stratus Pharmaceuticals Inc.
  • Taro Pharmaceuticals USA
  • Thao MD David
  • Truett Laboratories
  • Valeant Ltd.
Dosage Forms
FormRouteStrength
KitOphthalmic; Respiratory (inhalation); Topical
SalveTopical
LotionTopical17 g/200g
OintmentTopical
KitOral; Topical
PasteTopical
Kit; ointment; stickTopical
KitTopical
Cloth; creamTopical
Kit; salveTopical
GelTopical
StickOral
SolutionTopical
Gel; kit; lotionTopical
Gel; kit; lipstick; liquid; lotion; swabTopical
Liquid; lotionTopical
JellyTopical
OilTopical
CreamTopical
Cream, augmentedTopical
LiquidTopical
SuspensionTopical
PowderTopical
Lotion / shampooTopical
Kit; stickTopical
Kit; ointmentTopical
LipstickTopical
Cream; kitTopical
EmulsionTopical
Cream; kit; lotionTopical
Kit; lotionTopical
LotionCutaneous
AerosolTopical
Spray, suspensionTopical
SprayOral
StickTopical
SprayTopical
LotionTopical
Liquid; sprayTopical
LotionOral
ClothTopical
Kit; liquidTopical
Lotion; sprayTopical
Aerosol, foamTopical
Aerosol, sprayTopical
LiquidTopical0.05 g/100g
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)65.5 °CPhysProp
boiling point (°C)155 °C at 5.00E+00 mm HgPhysProp
logP3.79CHEM INSPECT TEST INST (1992)
Predicted Properties
PropertyValueSource
Water Solubility0.128 mg/mLALOGPS
logP3.35ALOGPS
logP3.62Chemaxon
logS-3.2ALOGPS
pKa (Strongest Acidic)7.07Chemaxon
pKa (Strongest Basic)-4.8Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area46.53 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity65.08 m3·mol-1Chemaxon
Polarizability23.96 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.9973
Blood Brain Barrier+0.8691
Caco-2 permeable+0.9258
P-glycoprotein substrateNon-substrate0.6198
P-glycoprotein inhibitor INon-inhibitor0.7188
P-glycoprotein inhibitor IINon-inhibitor0.8124
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.703
CYP450 2D6 substrateNon-substrate0.8915
CYP450 3A4 substrateNon-substrate0.6542
CYP450 1A2 substrateInhibitor0.911
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9437
CYP450 2C19 inhibitorInhibitor0.8995
CYP450 3A4 inhibitorNon-inhibitor0.9258
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5
Ames testNon AMES toxic0.9098
CarcinogenicityNon-carcinogens0.8403
BiodegradationNot ready biodegradable0.6452
Rat acute toxicity1.6986 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9358
hERG inhibition (predictor II)Non-inhibitor0.9337
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (8.57 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-004i-0390000000-d20281152dd02868f0f4
GC-MS Spectrum - EI-BGC-MSsplash10-004i-1190000000-c313f66363430324ce8e
Mass Spectrum (Electron Ionization)MSsplash10-0fb9-5970000000-201ffa188f10c8981e9e
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0900000000-25520d89872ff52a3ed3
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-004i-0090000000-91e535fa71de15e79004
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-004i-0390000000-440768455ae7530c1909
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0910000000-d7fdecc4ef3f7a731749
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0900000000-e961d0acc366c6018be1
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-1900000000-7c8fdbbdfd111f438a02
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0zfs-5900000000-daad8bf207afcb7e0b35
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-004i-0090000000-f005541a3bcdeecd4a50
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-004i-0390000000-4d6d607f4d00d653af57
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0910000000-5bd3907cf283f3acd696
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0900000000-2952f2aadcf45f405c21
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-1900000000-d9d09a5a4ce6a4afa1f2
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0zfs-5900000000-bd6b959b532a530b3906
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0900000000-c3d717596cccd924dc19
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-004i-0590000000-4e2b5ecc7de18b351252
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0900000000-465387cfd8d500df1516
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-004j-9400000000-e9226c86961ff5d9d15b
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0ufr-0940000000-2a55f01ddfa3b0ff8f42
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0ufr-0950000000-1544559b42fcf578bf82
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Targets

Build, predict & validate machine-learning models
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insights and accelerate drug research.
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Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Antagonist
General Function
Zinc ion binding
Specific Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor ...
Gene Name
PGR
Uniprot ID
P06401
Uniprot Name
Progesterone receptor
Molecular Weight
98979.96 Da
References
  1. Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B: Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005 Feb;83(2):264-72. Epub 2004 Nov 10. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Antagonist
General Function
Zinc ion binding
Specific Function
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription ...
Gene Name
AR
Uniprot ID
P10275
Uniprot Name
Androgen receptor
Molecular Weight
98987.9 Da
References
  1. Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B: Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005 Feb;83(2):264-72. Epub 2004 Nov 10. [Article]
  2. Araki N, Ohno K, Nakai M, Takeyoshi M, Iida M: Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro. 2005 Sep;19(6):831-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissu...
Gene Name
ESR1
Uniprot ID
P03372
Uniprot Name
Estrogen receptor
Molecular Weight
66215.45 Da
References
  1. Matsumoto H, Adachi S, Suzuki Y: [Estrogenic activity of ultraviolet absorbers and the related compounds]. Yakugaku Zasshi. 2005 Aug;125(8):643-52. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent m...
Gene Name
ESR2
Uniprot ID
Q92731
Uniprot Name
Estrogen receptor beta
Molecular Weight
59215.765 Da
References
  1. Matsumoto H, Adachi S, Suzuki Y: [Estrogenic activity of ultraviolet absorbers and the related compounds]. Yakugaku Zasshi. 2005 Aug;125(8):643-52. [Article]

Drug created at July 24, 2007 12:56 / Updated at February 21, 2021 18:51