Oxybenzone
Identification
- Summary
Oxybenzone is a sunscreen agent found in sunscreens that absorbs UV rays.
- Brand Names
- Meijer
- Generic Name
- Oxybenzone
- DrugBank Accession Number
- DB01428
- Background
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
- Weight
- Average: 228.2433
Monoisotopic: 228.07864425 - Chemical Formula
- C14H12O3
- Synonyms
- 2-Benzoyl-5-methoxyphenol
- 2-Hydroxy-4-methoxybenzophenone
- 4-Methoxy-2-hydroxybenzophenone
- Benzophenone-3
- Oxibenzona
- Oxybenzone
- Oxybenzonum
- External IDs
- NSC-7778
Pharmacology
- Indication
Used as an ingredient in sunscreen and other cosmetics.
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- Contraindications & Blackbox Warnings
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- Pharmacodynamics
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.
- Mechanism of action
Oxybenzone absorbs UV-A ultraviolet rays, preventing them from reaching the skin.
Target Actions Organism UProgesterone receptor antagonistHumans UAndrogen receptor antagonistHumans UEstrogen receptor alpha Not Available Humans UEstrogen receptor beta Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
In vivo studies show oxybenzone is abosorbed transdermally (through the skin) and is excreted in the urine.
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Abacavir may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Aceclofenac Aceclofenac may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Acetaminophen Acetaminophen may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Acetazolamide Acetazolamide may increase the excretion rate of Oxybenzone which could result in a lower serum level and potentially a reduction in efficacy. Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Aclidinium Oxybenzone may decrease the excretion rate of Aclidinium which could result in a higher serum level. Acrivastine Oxybenzone may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir Acyclovir may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Active Moieties
Name Kind UNII CAS InChI Key Benzophenone unknown 701M4TTV9O 119-61-9 RWCCWEUUXYIKHB-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Bebak Baby Sun Lotion 17 g/200g Topical SORA KOZMETIK SANAYI TICARET ANONIM SIRKETI 2020-07-16 Not applicable US Zep Sun Screen Towels Liquid 0.05 g/100g Topical Zep Inc. 2013-05-01 2020-01-02 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 100 SPF Cream Oxybenzone (6 % w/w) + Avobenzone (3 % w/w) + Homosalate (15 % w/w) + Octisalate (5 % w/w) + Octocrylene (10 % w/w) Cream Topical Vital Science A Div. Of/Une Div. De Valeant Canada Ltd/Ltee 2010-06-03 2014-08-27 Canada 1177, 1178 Sunscreen Oxybenzone (5 g/100g) + Homosalate (6 g/100g) + Octinoxate (7.5 g/100g) + Octisalate (5 g/100g) Cream Topical Dynarex 2021-05-27 Not applicable US 14-day Skin Rescue SPF 30 Oxybenzone (6 % w/w) + Avobenzone (3 % w/w) + Homosalate (4 % w/w) + Octisalate (5 % w/w) + Octocrylene (2.35 % w/w) Cream Topical Johnson & Johnson 2009-02-16 2013-07-31 Canada 15 SPF Fps Premium Sunscreen Oxybenzone (2 % w/w) + Avobenzone (3 % w/w) + Ensulizole (2 % w/w) + Octocrylene (10 % w/w) Lotion Topical Empack Spraytech Inc 2005-05-04 2021-08-10 Canada 15 SPF Fps Sunscreen Lotion Écran Solaire Oxybenzone (3.0 % w/w) + Avobenzone (0.9 % w/w) + Octocrylene (3.0 % w/w) Lotion Topical Energizer Canada Inc 2007-03-01 2011-07-29 Canada 15 SPF Sunscreen Uva/uvb Protection Oil-free Milky Spray Oxybenzone (2.0 %) + Avobenzone (3.0 %) + Octinoxate (5.0 %) + Octisalate (3.0 %) + Octocrylene (2.0 %) Emulsion Topical Coty Canada Inc. 2009-02-23 2013-07-24 Canada 15 SPF Sunscreen Uva/uvb Protection Vitalizing Age-defying Cream Oxybenzone (3.0 %) + Avobenzone (3.0 %) + Octinoxate (7.5 %) + Octisalate (5.0 %) + Octocrylene (2.0 %) Cream Topical Coty Canada Inc. 2009-02-23 2013-07-24 Canada 15 Spray Gel Sunscreen With Instant Bronzer Oxybenzone (0.5 %) + Avobenzone (2 %) + Octisalate (5 %) + Octocrylene (1.85 %) Gel Topical Prime Enterprises, Inc. 2018-04-09 2020-03-31 Canada 24K Bio-Brightening Skin Tone Moisturizer SPF 30 Oxybenzone (3.1 g/100g) + Avobenzone (1.5 g/100g) + Homosalate (6.2 g/100g) + Octinoxate (7.4 g/100g) + Octisalate (5 g/100g) Cream Topical Vivo Per-lei, Inc. 2014-10-03 2019-12-31 US 24K Skin Tone Moisturizer SPF 30 Oxybenzone (3.1 g/100g) + Avobenzone (1.5 g/100g) + Homosalate (6.2 g/100g) + Octinoxate (7.4 g/100g) + Octisalate (5.0 g/100g) Cream Topical Vivo Per-lei, Inc. 2019-07-29 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 4362 First Aid Kit Oxybenzone (6 g/100mL) + Ammonia (0.045 g/0.3mL) + Avobenzone (1 g/100mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Homosalate (5 g/100mL) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Octinoxate (7.5 g/100mL) + Octisalate (5 g/100mL) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc. 2018-09-13 Not applicable US Alphaquin HP Oxybenzone (50 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1g) Cream Topical Stratus Pharmaceuticals 1993-01-01 2017-02-01 US CoreTex Professional Outdoor Skin Protection Wallet Oxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL) Gel; Kit; Lipstick; Liquid; Lotion; Swab Topical CoreTex Products Inc 2019-11-27 Not applicable US CoreTex Professional Outdoor Skin Protection Wallet Oxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL) Gel; Kit; Lipstick; Liquid; Lotion; Swab Topical CoreTex Products Inc 2019-11-27 Not applicable US CoreTex Professional Outdoor Skin Protection Wallet Oxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL) Gel; Kit; Lipstick; Liquid; Lotion; Swab Topical CoreTex Products Inc 2019-11-27 Not applicable US Glytone Clarifying SunVanish with Sunscreen Oxybenzone (50 mg/1g) + Avobenzone (20 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1g) + Octocrylene (18.6 mg/1g) Cream Topical Genesis Pharmaceutical, Inc. 2012-06-13 2018-02-28 US Glytone SunVanish Skin Lightening Oxybenzone (50 mg/1g) + Avobenzone (20 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1g) + Octocrylene (18.6 mg/1g) Cream Topical Pierre Fabre USA Inc. 2012-06-13 2021-09-30 US Hydroquinone with sunscreens Oxybenzone (20 mg/1g) + Dioxybenzone (30 mg/1g) + Hydroquinone (40 mg/1g) + Padimate O (80 mg/1g) Cream Topical Preferreed Pharmaceuticals Inc. 2012-01-30 2017-01-31 US Nu-derm Starter Set Normal-dry Skin Transformation System Oxybenzone (55 mg/1g) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1mL) + Octinoxate (75 mg/1g) + Zinc oxide (90 mg/1mL) Kit Topical OMP, INC. 2007-08-20 Not applicable US Nu-derm Starter Set Normal-oily Skin Transformation System Oxybenzone (55 mg/1g) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1mL) + Octinoxate (75 mg/1g) + Zinc oxide (90 mg/1mL) Kit Topical OMP, INC. 2004-12-02 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Benzophenones
- Direct Parent
- Benzophenones
- Alternative Parents
- Diphenylmethanes / Aryl-phenylketones / Methoxyphenols / Phenoxy compounds / Methoxybenzenes / Benzoyl derivatives / Anisoles / Alkyl aryl ethers / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids show 3 more
- Substituents
- 1-hydroxy-2-unsubstituted benzenoid / 1-hydroxy-4-unsubstituted benzenoid / Alkyl aryl ether / Anisole / Aromatic homomonocyclic compound / Aryl ketone / Aryl-phenylketone / Benzophenone / Benzoyl / Diphenylmethane show 12 more
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- monomethoxybenzene, hydroxybenzophenone (CHEBI:34283)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 95OOS7VE0Y
- CAS number
- 131-57-7
- InChI Key
- DXGLGDHPHMLXJC-UHFFFAOYSA-N
- InChI
- InChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3
- IUPAC Name
- 2-benzoyl-5-methoxyphenol
- SMILES
- COC1=CC(O)=C(C=C1)C(=O)C1=CC=CC=C1
References
- General References
- Gonzalez H, Farbrot A, Larko O, Wennberg AM: Percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiation. Br J Dermatol. 2006 Feb;154(2):337-40. [Article]
- External Links
- Human Metabolome Database
- HMDB0015497
- KEGG Drug
- D05309
- KEGG Compound
- C14285
- PubChem Compound
- 4632
- PubChem Substance
- 46508419
- ChemSpider
- 4471
- BindingDB
- 50253134
- 32673
- ChEBI
- 34283
- ChEMBL
- CHEMBL1625
- ZINC
- ZINC000000136138
- PharmGKB
- PA164742933
- Wikipedia
- Oxybenzone
- MSDS
- Download (73.7 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Supportive Care Atrophic Vaginitis / Endometrial Hyperplasia / Pelvic Organ Prolapse (POP) 1 4 Completed Supportive Care Skin Irritation 1 4 Completed Treatment Acne Prone Skin 1 4 Completed Treatment Actinic Keratosis (AK) 1 4 Completed Treatment Chronic Hand Eczema (CHE) 1 4 Completed Treatment Hypertrophic Cicatrix / Keloids Scars / Scars, Hypertrophic 1 4 Completed Treatment Melasma 1 4 Recruiting Treatment Breast Cancer / Vulvo Vaginal Atrophy 1 4 Terminated Not Available Skin Aging 1 3 Completed Treatment Atopic Dermatitis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Axia Medical Solutions LLC
- Beaura SPA Parker Center
- Body Sculpting Center
- Cosmetic Laser Skin Care
- Dermatech
- Dulles Cosmetic Surgery and Skin Care Center
- Fairfield County Plastic Surgery
- Genesis Pharmaceutical Inc.
- Legacy Pharmaceuticals Packaging LLC
- Obagi Medical Products Inc.
- Paul Goco MD
- Plastic Surgery Associates PC
- Puretek Corp.
- Qualitest
- River's Edge Pharmaceuticals
- Rulian Md Peter
- Schooler Medical Professionals
- Sheffield Laboratories Div Faria Limited LLC
- Sonar Products Inc.
- Stratus Pharmaceuticals Inc.
- Taro Pharmaceuticals USA
- Thao MD David
- Truett Laboratories
- Valeant Ltd.
- Dosage Forms
Form Route Strength Kit Ophthalmic; Respiratory (inhalation); Topical Salve Topical Lotion Topical 17 g/200g Ointment Topical Kit Oral; Topical Paste Topical Kit; ointment; stick Topical Kit Topical Cloth; cream Topical Kit; salve Topical Gel Topical Stick Oral Solution Topical Gel; kit; lotion Topical Gel; kit; lipstick; liquid; lotion; swab Topical Liquid; lotion Topical Jelly Topical Oil Topical Cream Topical Cream, augmented Topical Liquid Topical Suspension Topical Powder Topical Lotion / shampoo Topical Kit; stick Topical Kit; ointment Topical Lipstick Topical Cream; kit Topical Emulsion Topical Cream; kit; lotion Topical Kit; lotion Topical Lotion Cutaneous Aerosol Topical Spray, suspension Topical Spray Oral Stick Topical Spray Topical Lotion Topical Liquid; spray Topical Lotion Oral Cloth Topical Kit; liquid Topical Lotion; spray Topical Aerosol, foam Topical Aerosol, spray Topical Liquid Topical 0.05 g/100g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 65.5 °C PhysProp boiling point (°C) 155 °C at 5.00E+00 mm Hg PhysProp logP 3.79 CHEM INSPECT TEST INST (1992) - Predicted Properties
Property Value Source Water Solubility 0.128 mg/mL ALOGPS logP 3.35 ALOGPS logP 3.62 Chemaxon logS -3.2 ALOGPS pKa (Strongest Acidic) 7.07 Chemaxon pKa (Strongest Basic) -4.8 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 46.53 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 65.08 m3·mol-1 Chemaxon Polarizability 23.96 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9973 Blood Brain Barrier + 0.8691 Caco-2 permeable + 0.9258 P-glycoprotein substrate Non-substrate 0.6198 P-glycoprotein inhibitor I Non-inhibitor 0.7188 P-glycoprotein inhibitor II Non-inhibitor 0.8124 Renal organic cation transporter Non-inhibitor 0.8178 CYP450 2C9 substrate Non-substrate 0.703 CYP450 2D6 substrate Non-substrate 0.8915 CYP450 3A4 substrate Non-substrate 0.6542 CYP450 1A2 substrate Inhibitor 0.911 CYP450 2C9 inhibitor Non-inhibitor 0.907 CYP450 2D6 inhibitor Non-inhibitor 0.9437 CYP450 2C19 inhibitor Inhibitor 0.8995 CYP450 3A4 inhibitor Non-inhibitor 0.9258 CYP450 inhibitory promiscuity High CYP Inhibitory Promiscuity 0.5 Ames test Non AMES toxic 0.9098 Carcinogenicity Non-carcinogens 0.8403 Biodegradation Not ready biodegradable 0.6452 Rat acute toxicity 1.6986 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9358 hERG inhibition (predictor II) Non-inhibitor 0.9337
Spectra
- Mass Spec (NIST)
- Download (8.57 KB)
- Spectra
Targets

- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Antagonist
- General Function
- Zinc ion binding
- Specific Function
- The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor ...
- Gene Name
- PGR
- Uniprot ID
- P06401
- Uniprot Name
- Progesterone receptor
- Molecular Weight
- 98979.96 Da
References
- Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B: Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005 Feb;83(2):264-72. Epub 2004 Nov 10. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Antagonist
- General Function
- Zinc ion binding
- Specific Function
- Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription ...
- Gene Name
- AR
- Uniprot ID
- P10275
- Uniprot Name
- Androgen receptor
- Molecular Weight
- 98987.9 Da
References
- Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B: Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005 Feb;83(2):264-72. Epub 2004 Nov 10. [Article]
- Araki N, Ohno K, Nakai M, Takeyoshi M, Iida M: Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro. 2005 Sep;19(6):831-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissu...
- Gene Name
- ESR1
- Uniprot ID
- P03372
- Uniprot Name
- Estrogen receptor
- Molecular Weight
- 66215.45 Da
References
- Matsumoto H, Adachi S, Suzuki Y: [Estrogenic activity of ultraviolet absorbers and the related compounds]. Yakugaku Zasshi. 2005 Aug;125(8):643-52. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent m...
- Gene Name
- ESR2
- Uniprot ID
- Q92731
- Uniprot Name
- Estrogen receptor beta
- Molecular Weight
- 59215.765 Da
References
- Matsumoto H, Adachi S, Suzuki Y: [Estrogenic activity of ultraviolet absorbers and the related compounds]. Yakugaku Zasshi. 2005 Aug;125(8):643-52. [Article]
Drug created at July 24, 2007 12:56 / Updated at February 21, 2021 18:51