Corticotropin-releasing hormone receptor 2

BE0014244ProteinHumansCRHR2

G protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11329063, PubMed:11416224, PubMed:20966082, PubMed:22689579, PubMed:32004470, PubMed:36335102). It is acted on by 3 drugs in DrugBank.

Gene name
CRHR2
UniProtKB entry
Q13324Swiss-Prot
Cellular location
Cell membrane
Residues / weight
411 residues · 47,687 Da
Also known as
Corticotropin-releasing factor receptor 2 · CRF-R-2 · CRF-R2 · CRF2R · CRFR-2

Resolves to

Protein
UniProtQ13324UniProt nameCRHR2_HUMAN
Gene
HGNCHGNC:2358NCBI Gene1395GeneCardsCRHR2
Pharmacology
IUPHAR/GtoPdb213KEGGhsa:1395
Structure
PDB3N93PDB3N95PDB3N96
Drugs

What you can answer from here — as of June 19, 2026

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
14GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Corticotropin-releasing hormone receptor 2, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In