Corticotropin-releasing hormone receptor 2

BE0014244ProteinHumansCRHR2

G protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11329063, PubMed:11416224, PubMed:20966082, PubMed:22689579, PubMed:32004470, PubMed:36335102). It is acted on by 3 drugs in DrugBank.

Gene name
CRHR2
UniProtKB entry
Q13324Swiss-Prot
Cellular location
Cell membrane
Residues / weight
411 residues · 47,687 Da
Also known as
Corticotropin-releasing factor receptor 2 · CRF-R-2 · CRF-R2 · CRF2R · CRFR-2

Resolves to

Protein
UniProtQ13324UniProt nameCRHR2_HUMAN
Gene
HGNCHGNC:2358NCBI Gene1395GeneCardsCRHR2
Pharmacology
IUPHAR/GtoPdb213KEGGhsa:1395
Structure
PDB3N93PDB3N95PDB3N96
Drugs

What you can answer from here — as of June 19, 2026

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Corticotropin-releasing hormone receptor 2, how selective are they, and which programs against it are still in active trials?

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