Corticorelin
Identification
- Summary
Corticorelin is a synthetic corticotropin-releasing factor analog used to diagnose causes of excessive adrenocorticotropic hormone (ACTH) production.
- Generic Name
- Corticorelin
- DrugBank Accession Number
- DB05394
- Background
Corticotropin-releasing factor is studied in the treatment of brain cancer. It is made naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory. Human corticotropin-releasing factor may help reduce symptoms caused by edema (swelling) of the brain. It is a type of neurohormone, also called hCRF.
- Type
- Small Molecule
- Groups
- Investigational
- Synonyms
- Corticoliberin human
- Corticorelin
- Corticorelin (human)
- Corticotropin releasing hormone human
- Corticotropin-releasing factor
- Corticotropin-releasing factor (human)
- Corticotropin-releasing hormone
- CRF
- hCRF
- Human corticoliberin
- Human corticotropin-releasing factor
- External IDs
- NEU-3002
Pharmacology
- Indication
Investigated for use/treatment in brain cancer and neurologic disorders.
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- Pharmacodynamics
Not Available
- Mechanism of action
Corticotropin-releasing factor is produced by neuroendocrine cells in the paraventricular nucleus of the hypothalamus and is released from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system. The portal system carries the Corticotropin-releasing hormone(CRH) to the anterior lobe of the pituitary where it stimulates the secretion of corticotropin (ACTH) and other biologically active substances.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Categories
- ATC Codes
- V04CD04 — Corticorelin
- Drug Categories
- Amino Acids, Peptides, and Proteins
- Corticotropin-Releasing Hormone
- Diagnostic Agents
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Hypothalamic Hormones
- Nerve Tissue Proteins
- Neuropeptides
- Peptide Hormones
- Peptides
- Pituitary Hormone-Releasing Hormones
- Proteins
- Tests for Pituitary Function
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 305OE8862Y
- CAS number
- 86784-80-7
References
- General References
- Hoare SR, Sullivan SK, Ling N, Crowe PD, Grigoriadis DE: Mechanism of corticotropin-releasing factor type I receptor regulation by nonpeptide antagonists. Mol Pharmacol. 2003 Mar;63(3):751-65. [Article]
- Lowery EG, Sparrow AM, Breese GR, Knapp DJ, Thiele TE: The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice. Alcohol Clin Exp Res. 2008 Feb;32(2):240-8. Epub 2007 Dec 21. [Article]
- Panickar KS: Corticorelin, a synthetic human corticotropin-releasing factor analog, for the treatment of peritumoral brain edema. Curr Opin Mol Ther. 2010 Dec;12(6):780-9. [Article]
- External Links
- PubChem Substance
- 347910116
- 214461
- Wikipedia
- Corticotropin-releasing_hormone
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Basic Science Healthy Subjects (HS) 1 3 Completed Treatment Brain Neoplasm / Brain Swelling 2 3 Withdrawn Treatment Brain Neoplasm / Brain Swelling 1 1 Active Not Recruiting Basic Science Sleep Restriction 1 1 Completed Basic Science Stress (Psychology) 1 1 Completed Treatment Edema 1 1, 2 Terminated Treatment Brain Neoplasm / Brain Swelling 1 0 Active Not Recruiting Basic Science Sleep Restriction 1 Not Available Completed Not Available Adrenal Gland Hyperfunction / Adrenal Gland Hypofunction / Cushing's Syndrome / Healthy Subjects (HS) 1 Not Available Completed Not Available Cocaine Related Disorders / Dependence, Cocaine / Substance Related Disorders 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, powder, for solution Parenteral 100 μg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- L-ascorbic acid binding
- Specific Function
- Conversion of dopamine to noradrenaline.
- Gene Name
- DBH
- Uniprot ID
- P09172
- Uniprot Name
- Dopamine beta-hydroxylase
- Molecular Weight
- 69064.45 Da
References
- Lima L, Sourkes TL: Effect of corticotropin-releasing factor on adrenal DBH and PNMT activity. Peptides. 1987 May-Jun;8(3):437-41. [Article]
Drug created at November 18, 2007 18:24 / Updated at November 30, 2023 01:44