Corticorelin ovine triflutate is a synthetic corticotropin-releasing hormone used for diagnostic purposes in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome. Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary.
- Mechanism
- Curator reviewed
Corticorelin is a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.
- Primary indication
- Corticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.Curator reviewed · 1 structured indication
- First approval
- United States, 1997
- Also known as
- Corticorelin ovine · Corticorelin triflutate · Corticotropin-releasing factor (sheep hypothalamus) · Corticotropin-releasing factor (sheep) · Ovine ACTH releasing factor
- Brand names
Resolves to
What you can answer from here — as of August 31, 2026
Which drugs share a target with Corticorelin ovine triflutate, and which of those have an active Phase 3 trial?
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