Translation initiation factor eIF2B subunit alpha

BE0014461ProteinHumansEIF2B1

Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). It is acted on by 1 drug in DrugBank.

Gene name
EIF2B1
UniProtKB entry
Q14232Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
305 residues · 33,712 Da
Also known as
eIF2B GDP-GTP exchange factor subunit alpha · EIF2BA

Resolves to

Protein
UniProtQ14232UniProt nameEI2BA_HUMAN
Gene
HGNCHGNC:3257NCBI Gene1967GeneCardsEIF2B1
Pharmacology
KEGGhsa:1967
Structure
PDB3ECSPDB6CAJPDB6EZO
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
15GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Translation initiation factor eIF2B subunit alpha, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In