Bromodomain-containing protein 3

BE0014531ProteinHumansBRD3

Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). It is acted on by 7 drugs in DrugBank.

Gene name
BRD3
UniProtKB entry
Q15059Swiss-Prot
Cellular location
Nucleus
Residues / weight
726 residues · 79,541 Da
Also known as
KIAA0043 · RING3-like protein · RING3L

Resolves to

Protein
UniProtQ15059UniProt nameBRD3_HUMAN
Gene
HGNCHGNC:1104NCBI Gene8019GeneCardsBRD3
Pharmacology
IUPHAR/GtoPdb2725KEGGhsa:8019
Structure
PDB24OSPDB2E7NPDB2NXB
Drugs

What you can answer from here — as of September 03, 2024

7DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bromodomain-containing protein 3, and which indications are they being tested in?

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