Bromodomain-containing protein 3
Details
- Name
- Bromodomain-containing protein 3
- Kind
- protein
- Synonyms
- KIAA0043
- RING3-like protein
- RING3L
- Gene Name
- BRD3
- UniProtKB Entry
- Q15059Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0057601|Bromodomain-containing protein 3 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS DSSDSE
- Number of residues
- 726
- Molecular Weight
- 79540.855
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity)
- Specific Function
- chromatin binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
- Not Available
- Chromosome Location
- 9
- Locus
- 9q34.2
- External Identifiers
Resource Link UniProtKB ID Q15059 UniProtKB Entry Name BRD3_HUMAN GeneCard ID BRD3 HGNC ID HGNC:1104 PDB ID(s) 2E7N, 2NXB, 2OO1, 2YW5, 3S91, 3S92, 5A7C, 5HFR, 5HJC, 6BGG, 6BGH, 6I41, 6I5P, 6I68, 6I7A, 6QJU, 6U4A, 6ULP, 7JMY, 7JQ8, 7JYN, 7JYZ, 7L72, 7L9L, 7LAY, 7LAZ, 7LB4, 7LBT, 7R8R, 7RJK, 7RJL, 7RJM, 7RJN, 7S3P, 7TO7, 7TO8, 7TO9, 7TOA, 7UG5, 8B5A, 8CV5 KEGG ID hsa:8019 IUPHAR/Guide To Pharmacology ID 2725 NCBI Gene ID 8019 - General References
- Not Available