Atypical chemokine receptor 1
BE0015068ProteinHumansACKR1
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. It is acted on by 2 drugs in DrugBank.
- Gene name
- ACKR1
- UniProtKB entry
- Q16570Swiss-Prot
- Cellular location
- Early endosome
- Residues / weight
- 336 residues · 35,552 Da
- Also known as
- DARC · Duffy antigen receptor for chemokines · Duffy antigen/chemokine receptor · Duffy blood group antigen · FY
Resolves to
Pharmacology
Drugs
What you can answer from here — as of September 03, 2024
Which approved drugs act on Atypical chemokine receptor 1, how selective are they, and which programs against it are still in active trials?
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