Phosphatidylcholine:ceramide cholinephosphotransferase 1

Details

Name
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Kind
protein
Synonyms
  • 2.7.8.27
  • Medulla oblongata-derived protein
  • MOB
  • Protein Mob
  • SMS1
  • Sphingomyelin synthase 1
  • TMEM23
  • Transmembrane protein 23
Gene Name
SGMS1
UniProtKB Entry
Q86VZ5Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0059393|Phosphatidylcholine:ceramide cholinephosphotransferase 1
MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRL
LDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPM
PELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRV
QWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGM
HFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYS
PRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEAS
QMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
Number of residues
413
Molecular Weight
48616.62
Theoretical pI
Not Available
GO Classification
Not Available
General Function
Major sphingomyelin synthase at the Golgi apparatus (PubMed:14685263, PubMed:17449912). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes (PubMed:14685263, PubMed:14976195, PubMed:17449912, PubMed:17982138, PubMed:19454763). Does not use free phosphorylcholine or CDP-choline as donor (PubMed:14685263, PubMed:14976195). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:14976195, PubMed:17449912, PubMed:17982138). Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:18370930, PubMed:21980337)
Specific Function
ceramide cholinephosphotransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
136-156 184-204 215-235 276-296 304-324
Cellular Location
Golgi apparatus membrane
Gene sequence
Not Available
Chromosome Location
10
Locus
10q11.23
External Identifiers
ResourceLink
UniProtKB IDQ86VZ5
UniProtKB Entry NameSMS1_HUMAN
GeneCard IDSGMS1
HGNC IDHGNC:29799
KEGG IDhsa:259230
IUPHAR/Guide To Pharmacology ID2520
NCBI Gene ID259230
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Idroxioleic acidinvestigationalyestargetmodulatorDetails