Poly(ADP-ribose) glycohydrolase

BE0016434ProteinHumansPARG

Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). It is acted on by 2 drugs in DrugBank.

Gene name
PARG
UniProtKB entry
Q86W56Swiss-Prot
Cellular location
Nucleus
Residues / weight
976 residues · 111,109 Da
Also known as
3.2.1.143

Resolves to

Protein
UniProtQ86W56UniProt namePARG_HUMAN
Gene
HGNCHGNC:8605NCBI Gene8505GeneCardsPARG
Pharmacology
KEGGhsa:8505
Structure
PDB4A0DPDB4B1GPDB4B1H
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Poly(ADP-ribose) glycohydrolase, how selective are they, and which programs against it are still in active trials?

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